HitPredict

Interactor 1: STX11 (O75558)
Syntaxin-11
Gene: STX11

Interactor 2: VAMP3 (Q15836)
Vesicle-associated membrane protein 3 (VAMP-3) (Cellubrevin) (CEB) (Synaptobrevin-3)
Gene: VAMP3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	1.00	0.892

Property	Details
Experiments	28514442, 33961781, 25244094, unassigned3799
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Synaptobrevin~Syntaxin
Common GO terms	GO:0005484 - SNAP receptor activity GO:0005886 - plasma membrane GO:0006887 - exocytosis GO:0031201 - SNARE complex GO:0061025 - membrane fusion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 287 Hs			1 100
+	Rn
		746117 STX1A_RAT (1-286): 3.03e-71: 223: 28.67		VAMP1_RAT (8-99): 1.23e-26: 96.2: 72.83
+	Dm
		614903 STX1A_DROME (10-286): 7.21e-68: 214: 26.72		SYB_DROME (6-97): 8.09e-30: 105: 59.78
+	Hs
		662336 STX1B_HUMAN (1-286): 1.33e-71: 223: 32.17		VAMP1_HUMAN (8-87): 1.97e-25: 93.1: 80.00
+	Dm
		1174524 STX1A_DROME (10-286): 7.21e-68: 214: 26.72		Q7JYX5_DROME (6-94): 8.63e-28: 101: 23.60
+	Rn
		746118 STX1A_RAT (1-286): 3.03e-71: 223: 28.67		VAMP7_RAT (7-80): 1.47e-23: 91.2: 35.14
+	Hs
		1154625 STX1A_HUMAN (1-286): 2.83e-70: 220: 28.67		VAMP3_HUMAN (1-81): 5.93e-26: 93.9: 100.00
+	Hs
		278503 STX1A_HUMAN (1-286): 2.83e-70: 220: 28.67		VAMP4_HUMAN (3-82): 2.08e-25: 93.9: 40.00
+	Dm
		1174551 STX1A_DROME (10-286): 7.21e-68: 214: 26.72		NSYB_DROME (6-93): 3.07e-27: 99.7: 63.64
+	Hs
		662345 STX1A_HUMAN (1-286): 2.83e-70: 220: 28.67		VAMP1_HUMAN (8-87): 1.97e-25: 93.1: 80.00
+	Hs
		908014 STX1A_HUMAN (1-286): 2.83e-70: 220: 28.67		VAMP7_HUMAN (7-79): 2.14e-23: 90.8: 31.51
+	Mm
		204922 STX1A_MOUSE (1-286): 2.39e-71: 223: 28.67		VAMP2_MOUSE (8-84): 9.13e-23: 86.6: 87.01
+	Rn
		746110 STX1A_RAT (1-286): 3.03e-71: 223: 28.67		VAMP2_RAT (8-84): 9.13e-23: 86.6: 87.01
+	Mm
		960324 STX1B_MOUSE (1-286): 1.33e-71: 223: 32.17		VAMP2_MOUSE (8-84): 9.13e-23: 86.6: 87.01
+	Hs
		960339 STX1B_HUMAN (1-286): 1.33e-71: 223: 32.17		VAMP2_HUMAN (8-84): 9.13e-23: 86.6: 87.01
+	Rn
		746121 STX1A_RAT (1-286): 3.03e-71: 223: 28.67		VAMP8_RAT (6-78): 1.58e-22: 85.4: 35.62
+	Hs
		989336 STX1A_HUMAN (1-286): 2.83e-70: 220: 28.67		VAMP2_HUMAN (8-84): 9.13e-23: 86.6: 87.01
+	Mm
		147440 STX1A_MOUSE (1-286): 2.39e-71: 223: 28.67		SC22B_MOUSE (8-97): 1.59e-20: 83.1: 25.56
+	Hs
		1159628 STX1A_HUMAN (1-286): 2.83e-70: 220: 28.67		VAMP8_HUMAN (6-82): 1.06e-22: 85.8: 35.07
+	Hs
		328656 STX1B_HUMAN (1-286): 1.33e-71: 223: 32.17		VAMP5_HUMAN (11-80): 1.65e-20: 80.8: 38.57
+	Hs
		328672 STX1A_HUMAN (1-286): 2.83e-70: 220: 28.67		VAMP5_HUMAN (11-80): 1.65e-20: 80.8: 38.57