HitPredict

Interactor 1: C3G (O77086)
Guanine nucleotide-releasing factor 2 (CRK SH3-binding GNRP) (DC3G)
Gene: C3G

Interactor 2: CRK (Q9XYM0)
Adapter molecule Crk
Gene: CRK

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.24	0.50	0.348

Property	Details
Experiments	unassigned4
Identification Methods	experimental interaction detection
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1571 Dm			1 271
+	Dm
		305035 C3G_DROME (1-1571): 0: 1984: 100.00		GRAP_DROME (109-257): 4.27e-21: 90.2: 16.35
+	Mm
		1225135 Q8C5V7_MOUSE (906-1565): 0: 628: 39.85		CRK_MOUSE (4-266): 3.51e-53: 176: 42.48
+	Mm
		868842 Q8C5V7_MOUSE (906-1565): 0: 628: 39.85		CRKL_MOUSE (4-267): 1.64e-52: 174: 42.38
+	Hs
		855599 SOS2_HUMAN (1130-1567): 2.42e-116: 401: 21.64		CRK_HUMAN (4-266): 6.15e-53: 176: 42.48
+	Hs
		855856 SOS2_HUMAN (1130-1567): 2.42e-116: 401: 21.64		CRKL_HUMAN (4-267): 9.7e-53: 175: 42.72
+	Hs
		109541 G5E9C8_HUMAN (1128-1569): 1.16e-113: 393: 20.63		CRKL_HUMAN (4-267): 9.7e-53: 175: 42.72
+	Hs
		855598 SOS1_HUMAN (1128-1569): 3.65e-113: 392: 20.63		CRK_HUMAN (4-266): 6.15e-53: 176: 42.48
+	Hs
		855855 SOS1_HUMAN (1128-1569): 3.65e-113: 392: 20.63		CRKL_HUMAN (4-267): 9.7e-53: 175: 42.72
+	Mm
		868839 SOS1_MOUSE (1142-1569): 1.75e-113: 393: 21.67		CRKL_MOUSE (4-267): 1.64e-52: 174: 42.38
+	Mm
		1036604 SOS2_MOUSE (1130-1567): 5.19e-117: 403: 21.64		PLCG2_MOUSE (3-270): 9.84e-40: 148: 13.88
+	Hs
		619038 SOS2_HUMAN (1130-1567): 2.42e-116: 401: 21.64		PLCG1_HUMAN (2-269): 1.77e-39: 147: 15.89
+	Mm
		1223508 SOS1_MOUSE (1142-1569): 1.75e-113: 393: 21.67		PLCG1_MOUSE (2-269): 3.48e-40: 150: 15.89
+	Hs
		292826 SOS2_HUMAN (1130-1567): 2.42e-116: 401: 21.64		GRAP2_HUMAN (4-258): 6.74e-39: 140: 17.31
+	Hs
		619037 SOS1_HUMAN (1128-1569): 3.65e-113: 392: 20.63		PLCG1_HUMAN (2-269): 1.77e-39: 147: 15.89
+	Hs
		1060722 SOS2_HUMAN (1130-1567): 2.42e-116: 401: 21.64		ITSN2_HUMAN (164-269): 2.54e-15: 77.8: 14.82
+	Mm
		1036602 SOS2_MOUSE (1130-1567): 5.19e-117: 403: 21.64		GRB2_MOUSE (205-256): 1.75e-13: 69.7: 28.30
+	Hs
		987578 SOS2_HUMAN (1130-1567): 2.42e-116: 401: 21.64		GRB2_HUMAN (205-256): 1.68e-13: 69.7: 28.30
+	Hs
		1060709 SOS2_HUMAN (1130-1567): 2.42e-116: 401: 21.64		ITSN1_HUMAN (157-267): 5.16e-12: 67.8: 12.30
+	Hs
		1060728 SOS2_HUMAN (1130-1567): 2.42e-116: 401: 21.64		CD2AP_HUMAN (97-198): 3.69e-10: 62.1: 17.14
+	Mm
		1221225 SOS1_MOUSE (1142-1569): 1.75e-113: 393: 21.67		GRB2_MOUSE (205-256): 1.75e-13: 69.7: 28.30