HitPredict

Interactor 1: SOS2 (Q07890)
Son of sevenless homolog 2 (SOS-2)
Gene: SOS2

Interactor 2: ITSN1 (Q15811)
Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17)
Gene: ITSN1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.48 1.00 0.698

The method score is based on:

Property Details
Experiments 35914814
Identification Methods two hybrid, two hybrid fragment pooling approach
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains RasGEF_N~RhoGEF, PH_13~RhoGEF, RhoGEF~RhoGEF, RhoGEF~SH3_1, RhoGEF~SH3_2, RhoGEF~SOS1_NGEF_PH, SH3_1~SOS1_NGEF_PH, SH3_2~SOS1_NGEF_PH
Common GO terms GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005829 - cytosol
GO:0005886 - plasma membrane
Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 1332
Hs

1 1721
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Service provided by Combinatics, Japan

Last updated: 11Aug2025