HitPredict

Interactor 1: CDK14 (O94921)
Cyclin-dependent kinase 14 (EC 2.7.11.22) (Cell division protein kinase 14) (Serine/threonine-protein kinase PFTAIRE-1) (hPFTAIRE1)
Gene: CDK14

Interactor 2: CCND3 (P30281)
G1/S-specific cyclin-D3
Gene: CCND3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.766

Property	Details
Experiments	17517622
Identification Methods	two hybrid, affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Cyclin_C~Pkinase, Cyclin_N~Pkinase
Common GO terms	GO:0000307 - cyclin-dependent protein kinase holoenzyme complex GO:0004693 - cyclin-dependent protein serine/threonine kinase activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm and 2 others more... GO:0005829 - cytosol GO:0051301 - cell division
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 469 Hs			1 292
+	Hs
		664638 CDK2_HUMAN (132-429): 4.68e-141: 408: 50.33		CCND1_HUMAN (2-292): 1.66e-100: 298: 51.86
+	Hs
		664708 CDK3_HUMAN (132-437): 2.13e-137: 398: 51.30		CCND1_HUMAN (2-292): 1.66e-100: 298: 51.86
+	Hs
		667764 CDK2_HUMAN (132-429): 4.68e-141: 408: 50.33		CCNA1_HUMAN (4-283): 4.46e-93: 284: 25.89
+	Hs
		573751 CDK2_HUMAN (132-429): 4.68e-141: 408: 50.33		CCNB1_HUMAN (10-285): 8.26e-89: 272: 23.02
+	Hs
		629061 CDK2_HUMAN (132-429): 4.68e-141: 408: 50.33		CCNA2_HUMAN (1-283): 1.91e-87: 269: 25.61
+	Hs
		667569 CDK2_HUMAN (132-429): 4.68e-141: 408: 50.33		CCND3_HUMAN (1-292): 8.64e-89: 267: 100.00
+	Hs
		573801 CDK3_HUMAN (132-437): 2.13e-137: 398: 51.30		CCNB1_HUMAN (10-285): 8.26e-89: 272: 23.02
+	At
		1185691 Q9CAG1_ARATH (5-466): 8.86e-128: 390: 27.43		CCA34_ARATH (3-287): 3.1e-92: 279: 22.34
+	Hs
		325466 CDK2_HUMAN (132-429): 4.68e-141: 408: 50.33		CCNB2_HUMAN (2-285): 2.81e-84: 260: 22.38
+	Hs
		629100 CDK3_HUMAN (132-437): 2.13e-137: 398: 51.30		CCNA2_HUMAN (1-283): 1.91e-87: 269: 25.61
+	Hs
		718881 CDK3_HUMAN (132-437): 2.13e-137: 398: 51.30		CCND3_HUMAN (1-292): 8.64e-89: 267: 100.00
+	Hs
		667568 CDK2_HUMAN (132-429): 4.68e-141: 408: 50.33		CCND2_HUMAN (1-292): 1.55e-81: 249: 61.15
+	Hs
		718885 CDK18_HUMAN (3-466): 1.05e-131: 390: 45.69		CCND3_HUMAN (1-292): 8.64e-89: 267: 100.00
+	Rn
		1048464 Q6P751_RAT (132-429): 5e-141: 408: 50.67		CCND2_RAT (1-292): 2.35e-80: 246: 60.47
+	Mm
		671888 CDK2_MOUSE (132-429): 7.05e-132: 386: 43.68		CCND1_MOUSE (2-292): 1.73e-85: 259: 51.86
+	Hs
		355336 CDK2_HUMAN (132-429): 4.68e-141: 408: 50.33		CCNE2_HUMAN (13-243): 1.84e-18: 86.7: 27.47
+	Hs
		667944 CDK2_HUMAN (132-429): 4.68e-141: 408: 50.33		Q8WUE3_HUMAN (13-243): 2.16e-18: 85.9: 27.47
+	Hs
		666939 CDK2_HUMAN (132-429): 4.68e-141: 408: 50.33		CCNE1_HUMAN (14-208): 1.35e-15: 78.2: 29.13
+	Hs
		355344 CDK3_HUMAN (132-437): 2.13e-137: 398: 51.30		CCNE2_HUMAN (13-243): 1.84e-18: 86.7: 27.47
+	Hs
		666973 CDK3_HUMAN (132-437): 2.13e-137: 398: 51.30		CCNE1_HUMAN (14-208): 1.35e-15: 78.2: 29.13