HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: GRB14 (Q14449)
Growth factor receptor-bound protein 14 (GRB14 adapter protein)
Gene: GRB14

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	8647858
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	BPS~PK_Tyr_Ser-Thr, PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0010008 - endosome membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 540
+	Mm
		699350 EGFR_MOUSE (1-1210): 0: 1267: 90.35		VAV_MOUSE (100-534): 9.35e-95: 308: 15.39
+	Hs
		362701 EGFR_HUMAN (1-1210): 0: 1246: 100.00		VAV_HUMAN (100-534): 2.31e-98: 318: 16.35
+	Hs
		362924 EGFR_HUMAN (1-1210): 0: 1246: 100.00		TEC_HUMAN (237-536): 1.31e-53: 193: 14.25
+	Hs
		362745 EGFR_HUMAN (1-1210): 0: 1246: 100.00		PLCG1_HUMAN (238-540): 3.28e-43: 167: 17.67
+	Hs
		362594 EGFR_HUMAN (1-1210): 0: 1246: 100.00		LCK_HUMAN (364-535): 1.49e-44: 166: 22.10
+	Hs
		363004 EGFR_HUMAN (1-1210): 0: 1246: 100.00		BMX_HUMAN (237-539): 2.95e-41: 159: 13.51
+	Hs
		362615 EGFR_HUMAN (1-1210): 0: 1246: 100.00		LYN_HUMAN (351-539): 1.63e-41: 158: 19.60
+	Hs
		362614 EGFR_HUMAN (1-1210): 0: 1246: 100.00		YES_HUMAN (376-538): 4.53e-41: 157: 20.47
+	Hs
		362630 EGFR_HUMAN (1-1210): 0: 1246: 100.00		HCK_HUMAN (368-536): 1.93e-40: 155: 20.79
+	Hs
		362647 EGFR_HUMAN (1-1210): 0: 1246: 100.00		FGR_HUMAN (402-535): 2.1e-40: 155: 22.14
+	Hs
		362923 EGFR_HUMAN (1-1210): 0: 1246: 100.00		MATK_HUMAN (399-531): 2.05e-35: 140: 28.89
+	Mm
		1030069 EGFR_MOUSE (1-1210): 0: 1267: 90.35		GRB2_MOUSE (435-523): 7.62e-28: 112: 31.46
+	Hs
		362715 EGFR_HUMAN (1-1210): 0: 1246: 100.00		FER_HUMAN (388-530): 8.22e-32: 132: 30.07
+	Hs
		362911 EGFR_HUMAN (1-1210): 0: 1246: 100.00		CSK_HUMAN (398-533): 1.08e-30: 126: 28.26
+	Mm
		767011 EGFR_MOUSE (1-1210): 0: 1267: 90.35		PTN11_MOUSE (428-526): 1.51e-21: 100: 35.78
+	Rn
		988078 Q9QX70_RAT (1-1210): 0: 1250: 90.34		GRB2_RAT (435-523): 6.9e-28: 112: 31.46
+	Hs
		362717 EGFR_HUMAN (1-1210): 0: 1246: 100.00		PLCG2_HUMAN (169-538): 2.58e-23: 106: 12.10
+	Hs
		292796 EGFR_HUMAN (1-1210): 0: 1246: 100.00		GRAP2_HUMAN (375-523): 4.54e-24: 104: 23.49
+	Hs
		362816 EGFR_HUMAN (1-1210): 0: 1246: 100.00		P85A_HUMAN (315-535): 1.51e-19: 94.5: 14.60
+	Hs
		362825 EGFR_HUMAN (1-1210): 0: 1246: 100.00		PTN6_HUMAN (421-523): 1.14e-14: 78.7: 26.79