Interactor 1: NCOA1 (Q15788)
Nuclear receptor coactivator 1 (NCoA-1) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 74) (bHLHe74) (Protein Hin-2) (RIP160) (Renal carcinoma antigen NY-REN-52) (Steroid receptor coactivator 1) (SRC-1)
Gene: NCOA1
Interactor 2: ESR2 (Q92731)
Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
Gene: ESR2
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.92 | 1.00 | 0.964 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 15604093, 11500849, 12554772, 11376110, 11014206, 10809226, 14715875, 10731636, 19126643 |
| Identification Methods | two hybrid, fluorescent resonance energy transfer, unspecified method, pull down, affinity chromatography technology |
| Interaction Type | direct interaction, physical association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | Hormone_recep~SRC-1 |
| Common GO terms | GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0030520 - estrogen receptor signaling pathway GO:0045893 - positive regulation of DNA-templated transcription and 1 others more... |
| Homologous interactions | 20 |
Homologous interactions (Top 20)
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
