HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: EPHB4 (P54760)
Ephrin type-B receptor 4 (EC 2.7.10.1) (Hepatoma transmembrane kinase) (Tyrosine-protein kinase TYRO11)
Gene: EPHB4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	39499777
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Furin-like~fn3, EphA2_TM~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~fn3, PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SAM_1, Recep_L_domain~fn3
Common GO terms	GO:0004714 - transmembrane receptor protein tyrosine kinase activity GO:0005524 - ATP binding GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0043235 - receptor complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1255 Hs			1 987
+	Hs
		410645 ERBB2_HUMAN (1-1255): 0: 1292: 100.00		EPHB2_HUMAN (17-982): 0: 1123: 55.08
+	Hs
		410735 ERBB2_HUMAN (1-1255): 0: 1292: 100.00		EPHB1_HUMAN (16-975): 0: 1122: 56.45
+	Hs
		410736 ERBB2_HUMAN (1-1255): 0: 1292: 100.00		EPHA4_HUMAN (3-977): 0: 1110: 49.90
+	Hs
		410733 ERBB2_HUMAN (1-1255): 0: 1292: 100.00		EPHA5_HUMAN (1-978): 0: 1101: 47.77
+	Hs
		410732 ERBB2_HUMAN (1-1255): 0: 1292: 100.00		EPHB3_HUMAN (14-980): 0: 1093: 58.61
+	Hs
		410644 ERBB2_HUMAN (1-1255): 0: 1292: 100.00		EPHA3_HUMAN (13-978): 0: 1087: 48.20
+	Hs
		410643 ERBB2_HUMAN (1-1255): 0: 1292: 100.00		EPHA2_HUMAN (15-974): 0: 1016: 44.82
+	Hs
		410614 ERBB2_HUMAN (1-1255): 0: 1292: 100.00		EPHA1_HUMAN (11-969): 0: 946: 39.96
+	Hs
		181769 ERBB2_HUMAN (1-1255): 0: 1292: 100.00		EPHB6_HUMAN (17-965): 0: 890: 41.65
+	Hs
		710252 ERBB4_HUMAN (6-1232): 0: 1103: 45.86		EPHA2_HUMAN (15-974): 0: 1016: 44.82
+	Hs
		410576 ERBB2_HUMAN (1-1255): 0: 1292: 100.00		INSRR_HUMAN (293-910): 1.99e-142: 460: 24.96
+	Hs
		410801 ERBB2_HUMAN (1-1255): 0: 1292: 100.00		MERTK_HUMAN (265-889): 2.9e-142: 452: 22.09
+	Hs
		410518 ERBB2_HUMAN (1-1255): 0: 1292: 100.00		INSR_HUMAN (380-894): 1.74e-134: 440: 29.27
+	Hs
		410532 ERBB2_HUMAN (1-1255): 0: 1292: 100.00		IGF1R_HUMAN (390-876): 7.15e-132: 432: 27.63
+	Hs
		410792 ERBB2_HUMAN (1-1255): 0: 1292: 100.00		FAK1_HUMAN (595-878): 1.01e-61: 230: 41.55
+	Hs
		362593 EGFR_HUMAN (16-1253): 0: 1078: 48.80		INSR_HUMAN (380-894): 1.74e-134: 440: 29.27
+	Hs
		410540 ERBB2_HUMAN (1-1255): 0: 1292: 100.00		HCK_HUMAN (593-875): 8.89e-63: 224: 41.55
+	Hs
		362619 EGFR_HUMAN (16-1253): 0: 1078: 48.80		IGF1R_HUMAN (390-876): 7.15e-132: 432: 27.63
+	Hs
		473422 ERBB4_HUMAN (6-1232): 0: 1103: 45.86		HCK_HUMAN (593-875): 8.89e-63: 224: 41.55
+	Hs
		362630 EGFR_HUMAN (16-1253): 0: 1078: 48.80		HCK_HUMAN (593-875): 8.89e-63: 224: 41.55