HitPredict

Interactor 1: LYN (P07948)
Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn)
Gene: LYN

Interactor 2: NRBP2 (Q9NSY0)
Nuclear receptor-binding protein 2 (Transformation-related gene 16 protein) (TRG-16)
Gene: NRBP2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0006974 - DNA damage response
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 512 Hs			1 501
+	Hs
		463607 LYN_HUMAN (1-512): 0: 621: 100.00		MARK2_HUMAN (11-469): 8.86e-115: 358: 15.58
+	Hs
		463366 LYN_HUMAN (1-512): 0: 621: 100.00		AKT2_HUMAN (3-358): 1.64e-117: 355: 14.63
+	Hs
		463817 LYN_HUMAN (1-512): 0: 621: 100.00		KS6B2_HUMAN (17-415): 2e-116: 353: 16.11
+	Hs
		557128 SRC_HUMAN (1-510): 0: 591: 51.97		AKT1_HUMAN (9-366): 1.16e-116: 353: 14.40
+	Hs
		557505 SRC_HUMAN (1-510): 0: 591: 51.97		KS6B2_HUMAN (17-415): 2e-116: 353: 16.11
+	Hs
		440132 LCK_HUMAN (1-512): 0: 585: 63.62		MARK2_HUMAN (11-469): 8.86e-115: 358: 15.58
+	Mm
		431326 SRC_MOUSE (1-510): 0: 587: 52.07		AKT1_MOUSE (9-366): 4.99e-117: 354: 14.40
+	Hs
		440402 FYN_HUMAN (1-510): 0: 583: 54.31		AKT1_HUMAN (9-366): 1.16e-116: 353: 14.40
+	Hs
		440769 FYN_HUMAN (1-510): 0: 583: 54.31		KS6B2_HUMAN (17-415): 2e-116: 353: 16.11
+	Hs
		440803 FYN_HUMAN (1-510): 0: 583: 54.31		WNK2_HUMAN (2-314): 1.23e-103: 342: 29.91
+	Hs
		440524 FYN_HUMAN (1-510): 0: 583: 54.31		STK4_HUMAN (14-500): 1.96e-111: 340: 15.29
+	Hs
		440528 FYN_HUMAN (1-510): 0: 583: 54.31		AAPK1_HUMAN (37-448): 2.17e-98: 309: 16.03
+	Hs
		343567 FRK_HUMAN (32-506): 0: 534: 48.47		OXSR1_HUMAN (23-501): 7.46e-116: 353: 14.87
+	Hs
		463496 LYN_HUMAN (1-512): 0: 621: 100.00		PAK1_HUMAN (4-317): 1.87e-76: 251: 23.57
+	Hs
		362422 ABL1_HUMAN (32-509): 1.52e-174: 523: 37.88		WNK2_HUMAN (2-314): 1.23e-103: 342: 29.91
+	Hs
		362271 ABL1_HUMAN (32-509): 1.52e-174: 523: 37.88		STK4_HUMAN (14-500): 1.96e-111: 340: 15.29
+	Hs
		728082 CSK_HUMAN (64-503): 1.56e-171: 493: 38.41		AKT1_HUMAN (9-366): 1.16e-116: 353: 14.40
+	Hs
		728225 PTK6_HUMAN (58-506): 1.13e-163: 473: 38.33		AKT1_HUMAN (9-366): 1.16e-116: 353: 14.40
+	Hs
		1054154 BTK_HUMAN (26-505): 7.72e-159: 468: 35.15		KS6B2_HUMAN (17-415): 2e-116: 353: 16.11