Interactor 1: HCK (P08631)
Tyrosine-protein kinase HCK (EC 2.7.10.2) (Hematopoietic cell kinase) (Hemopoietic cell kinase) (p59-HCK/p60-HCK) (p59Hck) (p61Hck)
Gene: HCK
Interactor 2: NGEF (Q8N5V2)
Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor)
Gene: NGEF
Species: Homo sapiens
Source: intact
Category: High-throughput
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.58 | 1.00 | 0.767 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 25814554, unassigned1126 |
| Identification Methods | two hybrid, two hybrid array, validated two hybrid |
| Interaction Type | direct interaction, physical association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | PK_Tyr_Ser-Thr~SH3_1, SH2~SH3_1, RhoGEF~SH3_1, SH3_1~SH3_1, SH3_1~SOS1_NGEF_PH |
| Common GO terms | GO:0005829 - cytosol GO:0030154 - cell differentiation GO:0032956 - regulation of actin cytoskeleton organization |
| Homologous interactions | 19 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
