HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: RN126 (Q9BV68)
E3 ubiquitin-protein ligase RNF126 (EC 2.3.2.27) (RING finger protein 126)
Gene: RNF126

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	1.00	0.885

Property	Details
Experiments	29167269, 38803224, 16196087, 22992278
Identification Methods	pull down, affinity chromatography technology, enzymatic study
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	ubiquitin~zf-RING_2, ubiquitin~zinc_ribbon_9
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 685 Hs			1 311
+	Hs
		476628 UBC_HUMAN (1-685): 0: 846: 100.00		RN115_HUMAN (10-307): 1.16e-57: 189: 43.00
+	Hs
		476347 UBC_HUMAN (1-685): 0: 846: 100.00		RNF38_HUMAN (55-272): 8.94e-35: 133: 25.11
+	Hs
		475946 UBC_HUMAN (1-685): 0: 846: 100.00		ARK2C_HUMAN (67-281): 1.9e-31: 122: 19.48
+	Hs
		476073 UBC_HUMAN (1-685): 0: 846: 100.00		PJA1_HUMAN (38-276): 2.32e-29: 119: 20.33
+	Hs
		476007 UBC_HUMAN (1-685): 0: 846: 100.00		GOLI_HUMAN (205-311): 1.76e-29: 118: 29.57
+	Hs
		475516 UBC_HUMAN (1-685): 0: 846: 100.00		TTC3_HUMAN (22-300): 1.94e-27: 114: 15.16
+	Hs
		476491 UBC_HUMAN (1-685): 0: 846: 100.00		RN181_HUMAN (193-283): 1.04e-29: 112: 34.07
+	At
		1210477 UBQ10_ARATH (305-685): 2.63e-153: 453: 95.80		Q9FM98_ARATH (8-310): 3.36e-41: 149: 21.74
+	At
		1091813 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		RNG1L_ARATH (2-304): 3.13e-49: 168: 24.35
+	At
		1092053 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		Q9FM98_ARATH (8-310): 3.36e-41: 149: 21.74
+	Mm
		476947 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		RN126_MOUSE (1-311): 4.83e-79: 244: 93.61
+	Hs
		475173 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		RN126_HUMAN (1-311): 3.19e-81: 250: 100.00
+	At
		477669 UBQ11_ARATH (533-685): 2.54e-59: 201: 95.43		Q9FM98_ARATH (8-310): 3.36e-41: 149: 21.74
+	Mm
		476994 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		RN115_MOUSE (10-291): 2.76e-59: 193: 44.52
+	Hs
		398150 ISG15_HUMAN (228-380): 1.72e-28: 113: 32.69		RN115_HUMAN (10-307): 1.16e-57: 189: 43.00
+	Hs
		924057 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		GOLI_HUMAN (205-311): 1.76e-29: 118: 29.57
+	Hs
		924199 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		RN181_HUMAN (193-283): 1.04e-29: 112: 34.07
+	Mm
		476987 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		RN181_MOUSE (177-283): 5.73e-32: 118: 32.14
+	Hs
		475090 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		GOLI_HUMAN (205-311): 1.76e-29: 118: 29.57
+	Hs
		475216 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		RN181_HUMAN (193-283): 1.04e-29: 112: 34.07