HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: UBP11 (P51784)
Ubiquitin carboxyl-terminal hydrolase 11 (EC 3.4.19.12) (Deubiquitinating enzyme 11) (Ubiquitin thioesterase 11) (Ubiquitin-specific-processing protease 11)
Gene: USP11

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	1.00	0.917

Property	Details
Experiments	28190767, 29576527, 33141564, 38803224, 22195557
Identification Methods	pull down, affinity chromatography technology, enzymatic study
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	DUSP~ubiquitin, UCH~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 685 Hs			1 963
+	Hs
		475693 UBC_HUMAN (1-685): 0: 846: 100.00		UBP4_HUMAN (73-933): 0: 656: 44.79
+	Hs
		476097 UBC_HUMAN (1-685): 0: 846: 100.00		UBP33_HUMAN (223-945): 9.3e-109: 360: 18.55
+	Hs
		476599 UBC_HUMAN (1-685): 0: 846: 100.00		UBP20_HUMAN (223-939): 3.73e-108: 358: 17.79
+	Hs
		475957 UBC_HUMAN (1-685): 0: 846: 100.00		UBP45_HUMAN (169-929): 6.98e-93: 314: 16.85
+	Hs
		475990 UBC_HUMAN (1-685): 0: 846: 100.00		UBP37_HUMAN (294-954): 5.73e-83: 290: 16.41
+	Hs
		476579 UBC_HUMAN (1-685): 0: 846: 100.00		UBP22_HUMAN (597-930): 2.39e-62: 222: 17.88
+	Hs
		271022 UBC_HUMAN (1-685): 0: 846: 100.00		UBP2_HUMAN (609-936): 9.85e-61: 220: 23.37
+	Hs
		475440 UBC_HUMAN (1-685): 0: 846: 100.00		UBP8_HUMAN (597-939): 3.73e-58: 219: 23.28
+	Hs
		476147 UBC_HUMAN (1-685): 0: 846: 100.00		UBP7_HUMAN (607-959): 9.02e-54: 205: 15.17
+	Hs
		64200 UBC_HUMAN (1-685): 0: 846: 100.00		UBP27_HUMAN (780-930): 2.09e-53: 194: 30.86
+	Hs
		476658 UBC_HUMAN (1-685): 0: 846: 100.00		UBP3_HUMAN (464-933): 1.42e-51: 191: 17.94
+	Hs
		476545 UBC_HUMAN (1-685): 0: 846: 100.00		UBP21_HUMAN (778-935): 1.96e-48: 183: 38.61
+	Hs
		301354 UBC_HUMAN (1-685): 0: 846: 100.00		UBP19_HUMAN (496-656): 3.05e-21: 102: 7.96
+	Hs
		475403 UBC_HUMAN (1-685): 0: 846: 100.00		UBP6_HUMAN (855-958): 1.57e-17: 90.4: 25.71
+	Hs
		476624 UBC_HUMAN (1-685): 0: 846: 100.00		UBP15_HUMAN (485-644): 1.32e-17: 90.4: 10.18
+	Hs
		476067 UBC_HUMAN (1-685): 0: 846: 100.00		UBP32_HUMAN (870-933): 2.66e-17: 89.7: 34.38
+	Hs
		475954 UBC_HUMAN (1-685): 0: 846: 100.00		UBP31_HUMAN (491-704): 4.93e-15: 82.3: 8.26
+	Hs
		476644 UBC_HUMAN (1-685): 0: 846: 100.00		UBP16_HUMAN (493-639): 2.36e-10: 66.5: 6.09
+	Sc
		477294 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		UBP5_YEAST (783-929): 1.36e-15: 83.6: 32.08
+	Sc
		477284 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		UBP12_YEAST (490-782): 1.79e-10: 67.3: 9.33