HitPredict

Interactor 1: GNAO (P09471)
Guanine nucleotide-binding protein G(o) subunit alpha (EC 3.6.5.-)
Gene: GNAO1

Interactor 2: RIC8A (Q9NPQ8)
Chaperone Ric-8A (Synembryn-A)
Gene: RIC8A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.808

Property	Details
Experiments	33961781, 12509430
Identification Methods	affinity chromatography technology, two hybrid, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	G-alpha~Ric8
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 354 Hs			1 531
+	Hs
		418747 GNAI2_HUMAN (1-354): 1.22e-170: 480: 69.30		RIC8A_HUMAN (1-531): 0: 763: 100.00
+	Hs
		989882 GNAI1_HUMAN (1-354): 2.12e-170: 480: 72.11		RIC8A_HUMAN (1-531): 0: 763: 100.00
+	Hs
		476042 GNAI3_HUMAN (1-354): 1.16e-167: 473: 71.27		RIC8A_HUMAN (1-531): 0: 763: 100.00
+	Hs
		1040979 GNA12_HUMAN (3-353): 1.4e-160: 456: 41.08		RIC8A_HUMAN (1-531): 0: 763: 100.00
+	Hs
		893526 GNAQ_HUMAN (1-353): 4.71e-161: 456: 50.85		RIC8A_HUMAN (1-531): 0: 763: 100.00
+	Hs
		716055 GNA11_HUMAN (1-353): 2.23e-157: 447: 50.57		RIC8A_HUMAN (1-531): 0: 763: 100.00
+	Hs
		618486 GNAZ_HUMAN (1-353): 2.31e-152: 434: 60.45		RIC8A_HUMAN (1-531): 0: 763: 100.00
+	Hs
		1125934 GNA13_HUMAN (2-353): 5.78e-144: 413: 42.94		RIC8A_HUMAN (1-531): 0: 763: 100.00
+	Ce
		908551 GNAO_CAEEL (1-354): 2.24e-170: 479: 82.20		RIC8_CAEEL (13-530): 0: 601: 25.57
+	Hs
		418753 GNAI2_HUMAN (1-354): 1.22e-170: 480: 69.30		RIC8B_HUMAN (10-527): 0: 587: 42.06
+	Hs
		893533 GNAQ_HUMAN (1-353): 4.71e-161: 456: 50.85		RIC8B_HUMAN (10-527): 0: 587: 42.06
+	Ce
		1427797 GPA16_CAEEL (1-354): 2.42e-152: 434: 63.13		RIC8_CAEEL (13-530): 0: 601: 25.57
+	Dm
		631767 GNAI_DROME (1-354): 7.95e-157: 445: 65.17		RIC8_DROME (10-513): 0: 564: 31.91