HitPredict

Interactor 1: GNAI2 (P04899)
Guanine nucleotide-binding protein G(i) subunit alpha-2 (Adenylate cyclase-inhibiting G alpha protein)
Gene: GNAI2

Interactor 2: RIC8B (Q9NVN3)
Chaperone Ric-8B (Brain synembryn) (hSyn) (Synembryn-B)
Gene: RIC8B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	26186194, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	G-alpha~Ric8
Common GO terms	GO:0005737 - cytoplasm GO:0005813 - centrosome GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007186 - G protein-coupled receptor signaling pathway
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 355 Hs			1 520
+	Hs
		893533 GNAQ_HUMAN (1-354): 9.29e-165: 465: 50.42		RIC8B_HUMAN (1-520): 0: 732: 100.00
+	Hs
		989806 GNAS2_HUMAN (1-355): 7.36e-145: 417: 38.83		RIC8B_HUMAN (1-520): 0: 732: 100.00
+	Hs
		418747 GNAI2_HUMAN (1-355): 8.82e-180: 503: 100.00		RIC8A_HUMAN (10-520): 0: 582: 42.06
+	Hs
		989882 GNAI1_HUMAN (1-355): 7.82e-178: 499: 87.89		RIC8A_HUMAN (10-520): 0: 582: 42.06
+	Hs
		476042 GNAI3_HUMAN (1-355): 8.25e-175: 491: 85.92		RIC8A_HUMAN (10-520): 0: 582: 42.06
+	Hs
		482641 GNAO_HUMAN (1-355): 1.32e-173: 488: 69.30		RIC8A_HUMAN (10-520): 0: 582: 42.06
+	Hs
		893526 GNAQ_HUMAN (1-354): 9.29e-165: 465: 50.42		RIC8A_HUMAN (10-520): 0: 582: 42.06
+	Hs
		716055 GNA11_HUMAN (1-354): 4.9e-162: 459: 50.42		RIC8A_HUMAN (10-520): 0: 582: 42.06
+	Hs
		618486 GNAZ_HUMAN (1-354): 7.1e-160: 453: 66.38		RIC8A_HUMAN (10-520): 0: 582: 42.06
+	Hs
		1125934 GNA13_HUMAN (2-354): 6.74e-153: 436: 39.72		RIC8A_HUMAN (10-520): 0: 582: 42.06
+	Ce
		908551 GNAO_CAEEL (1-355): 3.69e-171: 482: 68.17		RIC8_CAEEL (1-482): 9.77e-180: 518: 23.18
+	Ce
		1427797 GPA16_CAEEL (1-355): 1.59e-159: 452: 64.80		RIC8_CAEEL (1-482): 9.77e-180: 518: 23.18
+	Dm
		631767 GNAI_DROME (1-355): 9.56e-164: 463: 76.40		RIC8_DROME (3-465): 8.56e-169: 491: 30.68