HitPredict

Interactor 1: GNAI1 (P63096)
Guanine nucleotide-binding protein G(i) subunit alpha-1 (EC 3.6.5.-) (Adenylate cyclase-inhibiting G alpha protein)
Gene: GNAI1

Interactor 2: RIC8A (Q9NPQ8)
Chaperone Ric-8A (Synembryn-A)
Gene: RIC8A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.86 1.00 0.927

The method score is based on:

Property Details
Experiments 33961781, 12509430, 26186194, 28514442, 21988832
Identification Methods affinity chromatography technology, two hybrid, pull down, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains G-alpha~Ric8
Common GO terms GO:0005737 - cytoplasm
GO:0005886 - plasma membrane
GO:0005938 - cell cortex
GO:0007186 - G protein-coupled receptor signaling pathway
GO:0007193 - adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
Homologous interactions 13

Homologous interactions

Color coding for hit scores

1 354
Hs

1 531
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Service provided by Combinatics, Japan

Last updated: 11Aug2025