HitPredict

Interactor 1: TPM1 (P09493)
Tropomyosin alpha-1 chain (Alpha-tropomyosin) (Tropomyosin-1)
Gene: TPM1

Interactor 2: ACTZ (P61163)
Alpha-centractin (Centractin) (ARP1) (Actin-RPV) (Centrosome-associated actin homolog)
Gene: ACTR1A

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	38334954
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Actin~Tropomyosin
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 284 Hs			1 376
+	Hs
		447728 TPM3_HUMAN (1-284): 1.02e-43: 152: 91.20		ACTZ_HUMAN (1-376): 0: 771: 100.00
+	Hs
		464138 TPM2_HUMAN (1-284): 1.4e-38: 138: 85.56		ACTZ_HUMAN (1-376): 0: 771: 100.00
+	Hs
		958413 TPM4_HUMAN (42-284): 3.78e-33: 123: 68.72		ACTZ_HUMAN (1-376): 0: 771: 100.00
+	Hs
		447700 TPM3_HUMAN (1-284): 1.02e-43: 152: 91.20		ACTY_HUMAN (1-376): 0: 728: 90.43
+	Hs
		837211 TPM4_HUMAN (42-284): 3.78e-33: 123: 68.72		ACTY_HUMAN (1-376): 0: 728: 90.43
+	Dm
		387020 TPM2_DROME (1-282): 7.78e-35: 128: 49.29		ACT4_DROME (11-376): 0: 612: 52.70
+	Hs
		482868 TPM1_HUMAN (1-284): 2.36e-44: 153: 100.00		ACTB_HUMAN (7-376): 0: 581: 52.41
+	Hs
		482879 TPM1_HUMAN (1-284): 2.36e-44: 153: 100.00		ACTG_HUMAN (7-376): 0: 581: 52.67
+	Hs
		447727 TPM3_HUMAN (1-284): 1.02e-43: 152: 91.20		ACTB_HUMAN (7-376): 0: 581: 52.41
+	Hs
		447734 TPM3_HUMAN (1-284): 1.02e-43: 152: 91.20		ACTG_HUMAN (7-376): 0: 581: 52.67
+	Hs
		482876 TPM1_HUMAN (1-284): 2.36e-44: 153: 100.00		ACTA_HUMAN (5-376): 0: 576: 52.66
+	Hs
		482881 TPM1_HUMAN (1-284): 2.36e-44: 153: 100.00		ACTC_HUMAN (5-376): 0: 576: 52.93
+	Mm
		946685 TPM1_MOUSE (1-284): 1.73e-44: 153: 99.65		ACTA_MOUSE (5-376): 0: 576: 52.66
+	Oc
		946702 TPM1_RABIT (1-284): 1.73e-44: 153: 99.65		ACTS_RABIT (5-376): 0: 576: 52.39
+	Hs
		464137 TPM2_HUMAN (1-284): 1.4e-38: 138: 85.56		ACTB_HUMAN (7-376): 0: 581: 52.41
+	Ce
		534407 TPM1_CAEEL (1-282): 3.66e-37: 135: 58.51		ACT4_CAEEL (7-376): 0: 582: 52.67
+	Hs
		464145 TPM2_HUMAN (1-284): 1.4e-38: 138: 85.56		ACTS_HUMAN (5-376): 0: 576: 52.39
+	Dm
		482721 TPM2_DROME (1-282): 7.78e-35: 128: 49.29		ACT5_DROME (7-376): 0: 578: 52.14
+	Hs
		952730 TPM4_HUMAN (42-284): 3.78e-33: 123: 68.72		ACTB_HUMAN (7-376): 0: 581: 52.41
+	Dm
		482740 TPM2_DROME (1-282): 7.78e-35: 128: 49.29		ACT6_DROME (7-376): 0: 575: 52.67