HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: UBP4 (Q13107)
Ubiquitin carboxyl-terminal hydrolase 4 (EC 3.4.19.12) (Deubiquitinating enzyme 4) (Ubiquitin thioesterase 4) (Ubiquitin-specific-processing protease 4) (Ubiquitous nuclear protein homolog)
Gene: USP4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.971

Property	Details
Experiments	29576527, 33141564, 34642328, 38803224, 16196087, 20595234, 25404403, 30150323, 22195557, unassigned3799
Identification Methods	pull down, affinity chromatography technology, enzymatic study, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	DUSP~ubiquitin, UCH~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 685 Hs			1 963
+	Rn
		73543 UBC_RAT (1-637): 0: 779: 98.90		UBP4_RAT (1-963): 0: 897: 89.51
+	Hs
		508889 UBC_HUMAN (1-685): 0: 857: 100.00		UBP15_HUMAN (1-927): 0: 742: 57.88
+	Hs
		507702 UBC_HUMAN (1-685): 0: 857: 100.00		UBP11_HUMAN (6-937): 0: 727: 44.49
+	Hs
		322899 UBC_HUMAN (1-685): 0: 857: 100.00		UBP19_HUMAN (183-937): 3.28e-146: 469: 30.87
+	Hs
		508863 UBC_HUMAN (1-685): 0: 857: 100.00		UBP20_HUMAN (252-962): 2.05e-108: 359: 19.75
+	Hs
		508328 UBC_HUMAN (1-685): 0: 857: 100.00		UBP33_HUMAN (243-962): 1.23e-104: 349: 18.76
+	Hs
		508910 UBC_HUMAN (1-685): 0: 857: 100.00		UBP16_HUMAN (242-922): 1.52e-95: 321: 17.63
+	Hs
		508216 UBC_HUMAN (1-685): 0: 857: 100.00		UBP37_HUMAN (143-951): 1.39e-84: 295: 14.15
+	Hs
		508181 UBC_HUMAN (1-685): 0: 857: 100.00		UBP45_HUMAN (297-922): 3.98e-80: 279: 18.70
+	Hs
		288338 UBC_HUMAN (1-685): 0: 857: 100.00		UBP2_HUMAN (618-928): 2.38e-65: 233: 24.36
+	Hs
		507635 UBC_HUMAN (1-685): 0: 857: 100.00		UBP8_HUMAN (546-926): 5.42e-62: 231: 21.88
+	Hs
		508807 UBC_HUMAN (1-685): 0: 857: 100.00		UBP21_HUMAN (521-928): 1.27e-61: 221: 19.09
+	Hs
		508843 UBC_HUMAN (1-685): 0: 857: 100.00		UBP22_HUMAN (764-928): 1.15e-60: 218: 28.33
+	Rn
		1216904 UBC_RAT (1-637): 0: 779: 98.90		UBP2_RAT (618-928): 1.35e-63: 228: 24.36
+	Hs
		507596 UBC_HUMAN (1-685): 0: 857: 100.00		UBP6_HUMAN (857-954): 9.24e-21: 100: 30.30
+	Hs
		508296 UBC_HUMAN (1-685): 0: 857: 100.00		UBP32_HUMAN (857-954): 3.46e-20: 98.9: 30.30
+	Hs
		508925 UBC_HUMAN (1-685): 0: 857: 100.00		UBP3_HUMAN (303-482): 1.01e-15: 83.2: 29.74
+	Hs
		508178 UBC_HUMAN (1-685): 0: 857: 100.00		UBP31_HUMAN (483-684): 3.64e-12: 72.7: 6.01
+	Sc
		509565 UBI4P_YEAST (381-685): 4.09e-126: 380: 95.74		UBP5_YEAST (753-922): 1.14e-18: 93.6: 33.69
+	Sc
		509555 UBI4P_YEAST (381-685): 4.09e-126: 380: 95.74		UBP12_YEAST (478-755): 1.32e-12: 74.3: 7.29