Protein: UBP16
Ubiquitin carboxyl-terminal hydrolase 16 (EC 3.4.19.12) (Deubiquitinating enzyme 16) (Ubiquitin thioesterase 16) (Ubiquitin-processing protease UBP-M) (Ubiquitin-specific-processing protease 16)

Gene: UBP16, USP16
Organism: Homo sapiens
Interactions: 74
UniProt ID: Q9Y5T5

Gene Ontology (top 5):
GO:0003713 - transcription coactivator activity
GO:0004197 - cysteine-type endopeptidase activity
GO:0004843 - cysteine-type deubiquitinase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

508910

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

9

20

Small-scale

0.968

High

343122

HERC2
E3 ubiquitin-protein ligase HERC2

5

19

Small-scale

0.718

High

993054

RACK1
Small ribosomal subunit protein RACK1

1

4

High-throughput

0.691

High

443572

CDK1
Cyclin-dependent kinase 1

3

9

Small-scale

0.655

High

1491740

UBP16
Ubiquitin carboxyl-terminal hydrolase 16

1

16

Small-scale

0.647

High

1395440

NEUL4
Neuralized-like protein 4

3

4

High-throughput

0.604

High

419291

H2A1B
Histone H2A type 1-B/E

2

14

Small-scale

0.602

High

1162937

H2A2C
Histone H2A type 2-C

2

14

Small-scale

0.602

High

1436850

WDR54
WD repeat-containing protein 54

2

0

High-throughput

0.602

High

373629

MYC
Myc proto-oncogene protein

2

19

Small-scale

0.584

High

1459472

ZRAN1
Ubiquitin thioesterase ZRANB1

2

10

High-throughput

0.584

High

920403

PLK1
Serine/threonine-protein kinase PLK1

1

19

Small-scale

0.578

High

135749

DNM1L
Dynamin-1-like protein

1

3

Small-scale

0.561

High

245653

ZEB2
Zinc finger E-box-binding homeobox 2

1

8

Small-scale

0.561

High

685399

PAX6
Paired box protein Pax-6

1

1

High-throughput

0.541

High

248807

PEPL
Periplakin

1

20

High-throughput

0.536

High

539448

ODB2
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial

1

4

High-throughput

0.536

High

970205

RS16
Small ribosomal subunit protein uS9

1

2

High-throughput

0.536

High

973642

RS11
Small ribosomal subunit protein uS17

1

2

High-throughput

0.536

High

1408073

H2B1L
Histone H2B type 1-L

1

16

High-throughput

0.536

High

1491713

SRPRB
Signal recognition particle receptor subunit beta

1

3

High-throughput

0.536

High

182008

UBD
Ubiquitin D

1

20

Small-scale

0.527

High

1032795

SATB1
DNA-binding protein SATB1

1

0

High-throughput

0.518

High

1429833

XRN2
5'-3' exoribonuclease 2

1

0

High-throughput

0.518

High

533109

CH60
60 kDa heat shock protein, mitochondrial

1

3

High-throughput

0.515

High

595665

H15
Histone H1.5

1

6

High-throughput

0.515

High

1119053

BYST
Bystin

1

0

High-throughput

0.513

High

1179405

TSR1
Pre-rRNA-processing protein TSR1 homolog

1

0

High-throughput

0.513

High

1358057

OSCP1
Protein OSCP1

1

0

High-throughput

0.513

High

1410453

SOST
Sclerostin

1

0

High-throughput

0.513

High

502189

H2AZ
Histone H2A.Z

1

15

Small-scale

0.501

High

755044

H2B1B
Histone H2B type 1-B

1

17

Small-scale

0.501

High

755650

TTK
Dual specificity protein kinase TTK

1

2

Small-scale

0.501

High

1232748

H2A2A
Histone H2A type 2-A

1

14

Small-scale

0.501

High

1032280

EXOSX
Exosome complex component 10

1

3

High-throughput

0.481

High

135401

IF2B3
Insulin-like growth factor 2 mRNA-binding protein 3

1

6

Small-scale

0.479

High

173618

XPO1
Exportin-1

1

11

Small-scale

0.479

High

257022

H2B1K
Histone H2B type 1-K

1

17

High-throughput

0.479

High

302681

RNF8
E3 ubiquitin-protein ligase RNF8

1

18

Small-scale

0.479

High

346569

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

3

High-throughput

0.479

High

370827

FOS
Protein c-Fos

1

4

High-throughput

0.479

High

397331

ESR1
Estrogen receptor

1

15

Small-scale

0.479

High

658800

JAK1
Tyrosine-protein kinase JAK1

1

16

Small-scale

0.479

High

831726

CCNF
Cyclin-F

1

9

High-throughput

0.479

High

879675

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

4

High-throughput

0.479

High

885016

DGKG
Diacylglycerol kinase gamma

1

1

Small-scale

0.479

High

954333

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.479

High

981205

H2B1C
Histone H2B type 1-C/E/F/G/I

1

17

High-throughput

0.479

High

986839

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

6

High-throughput

0.479

High

1045956

TF65
Transcription factor p65

1

7

High-throughput

0.479

High

1050585

UBE3A
Ubiquitin-protein ligase E3A

1

14

Small-scale

0.479

High

1068346

AHNK
Neuroblast differentiation-associated protein AHNAK

1

5

High-throughput

0.479

High

1110222

HDAC1
Histone deacetylase 1

1

13

High-throughput

0.479

High

1137615

SUZ12
Polycomb protein SUZ12

1

1

High-throughput

0.479

High

1256284

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.479

High

1277045

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

3

High-throughput

0.479

High

1327303

FBXL6
F-box/LRR-repeat protein 6

1

4

High-throughput

0.479

High

1383205

LRC59
Leucine-rich repeat-containing protein 59

1

4

High-throughput

0.479

High

1405161

DNJC2
DnaJ homolog subfamily C member 2

1

5

High-throughput

0.479

High

1434354

PKHA4
Pleckstrin homology domain-containing family A member 4

1

17

High-throughput

0.479

High

1360784

JPH3
Junctophilin-3

1

2

High-throughput

0.470

High

1289752

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

1447512

ANLN
Anillin

1

0

High-throughput

0.458

High

1310563

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

3

Small-scale

0.457

High

658496

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.445

High

1037458

H11
Histone H1.1

1

4

High-throughput

0.445

High

809943

RS19
Small ribosomal subunit protein eS19

1

0

High-throughput

0.426

High

980623

H4
Histone H4

1

4

Small-scale

0.408

High

1293840

FBX11
F-box only protein 11

1

0

Small-scale

0.391

High

1295003

PTOV1
Prostate tumor-overexpressed gene 1 protein

1

0

Small-scale

0.391

High

337202

APOM
Apolipoprotein M

2

0

High-throughput

0.328

High

532006

PPBN
Alkaline phosphatase, germ cell type

2

0

High-throughput

0.328

High

692480

G0S2
G0/G1 switch protein 2

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025