HitPredict

Interactor 1: FGFR1 (P11362)
Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331)
Gene: FGFR1

Interactor 2: SLAP1 (Q13239)
Src-like-adapter (Src-like-adapter protein 1) (SLAP-1) (hSLAP)
Gene: SLA

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	15117958
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 822 Hs			1 276
+	Hs
		433229 FGFR1_HUMAN (1-822): 0: 861: 100.00		YES_HUMAN (24-275): 3.54e-89: 276: 28.52
+	Hs
		507818 FGFR1_HUMAN (1-822): 0: 861: 100.00		SRC_HUMAN (2-275): 2.76e-87: 271: 27.37
+	Hs
		507897 FGFR1_HUMAN (1-822): 0: 861: 100.00		ABL2_HUMAN (8-275): 6.54e-76: 252: 22.10
+	Hs
		507964 FGFR1_HUMAN (1-822): 0: 861: 100.00		ITK_HUMAN (5-275): 1.59e-76: 245: 21.53
+	Hs
		433573 FGFR2_HUMAN (1-821): 0: 803: 71.21		LYN_HUMAN (3-275): 4.33e-95: 290: 27.68
+	Hs
		412008 FGFR2_HUMAN (1-821): 0: 803: 71.21		FYN_HUMAN (8-274): 5.24e-90: 278: 29.03
+	Hs
		522773 FGFR2_HUMAN (1-821): 0: 803: 71.21		SRC_HUMAN (2-275): 2.76e-87: 271: 27.37
+	Hs
		433576 FGFR4_HUMAN (29-808): 0: 664: 55.60		LYN_HUMAN (3-275): 4.33e-95: 290: 27.68
+	Hs
		433602 EPHA3_HUMAN (3-775): 0: 643: 19.03		LYN_HUMAN (3-275): 4.33e-95: 290: 27.68
+	Hs
		412036 EPHA3_HUMAN (3-775): 0: 643: 19.03		FYN_HUMAN (8-274): 5.24e-90: 278: 29.03
+	Hs
		412104 EPHA5_HUMAN (3-791): 0: 639: 19.15		FYN_HUMAN (8-274): 5.24e-90: 278: 29.03
+	Hs
		433265 EPHB2_HUMAN (4-819): 0: 640: 18.07		YES_HUMAN (24-275): 3.54e-89: 276: 28.52
+	Hs
		607907 FGFR4_HUMAN (29-808): 0: 664: 55.60		ABL2_HUMAN (8-275): 6.54e-76: 252: 22.10
+	Hs
		522802 EPHA3_HUMAN (3-775): 0: 643: 19.03		SRC_HUMAN (2-275): 2.76e-87: 271: 27.37
+	Mm
		403425 EPHB2_MOUSE (4-819): 0: 640: 17.95		SRC_MOUSE (2-274): 3.56e-87: 271: 27.47
+	Hs
		522803 EPHB2_HUMAN (4-819): 0: 640: 18.07		SRC_HUMAN (2-275): 2.76e-87: 271: 27.37
+	Hs
		337359 EPHA3_HUMAN (3-775): 0: 643: 19.03		ABL1_HUMAN (2-275): 1.88e-79: 261: 23.40
+	Hs
		337360 EPHB2_HUMAN (4-819): 0: 640: 18.07		ABL1_HUMAN (2-275): 1.88e-79: 261: 23.40
+	Hs
		665558 EPHB2_HUMAN (4-819): 0: 640: 18.07		ABL2_HUMAN (8-275): 6.54e-76: 252: 22.10
+	Mm
		872619 EPHB2_MOUSE (4-819): 0: 640: 17.95		ABL2_MOUSE (8-275): 7.66e-74: 246: 21.74