HitPredict

Interactor 1: SPTCA (P13395)
Spectrin alpha chain
Gene: alpha-Spec

Interactor 2: SICK (Q9VIQ9)
Protein sickie
Gene: SICK

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.80	0.514

Property	Details
Experiments	36095217
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	CH~EF-hand_7, CH~EFhand_Ca_insen, CH~Spectrin
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2415 Dm			1 2197
+	Dm
		1028087 SPTCB_DROME (5-577): 9.95e-20: 99.8: 31.08		SICK_DROME (1-2197): 0: 1198: 100.00
+	Dm
		612406 ACTN_DROME (678-1113): 1.62e-18: 95.1: 14.44		SICK_DROME (1-2197): 0: 1198: 100.00
+	Dm
		561591 SPTCA_DROME (1-2415): 0: 619: 100.00		FLNA_DROME (14-300): 1.82e-29: 131: 14.98
+	Hs
		1040365 CP250_HUMAN (331-2403): 3.45e-69: 262: 9.08		DYST_HUMAN (7-157): 1.51e-32: 142: 19.87
+	Hs
		174704 SPTN2_HUMAN (9-1560): 3.16e-61: 236: 18.96		FLNA_HUMAN (16-468): 1.29e-35: 151: 12.75
+	Hs
		637462 SPTB2_HUMAN (5-1707): 1.15e-58: 228: 19.92		FLNA_HUMAN (16-468): 1.29e-35: 151: 12.75
+	Hs
		1028813 SPTB2_HUMAN (5-1707): 1.15e-58: 228: 19.92		NAV2_HUMAN (23-1397): 9.97e-27: 122: 13.39
+	Hs
		637503 SPTN1_HUMAN (2-1232): 6.72e-45: 182: 21.48		FLNA_HUMAN (16-468): 1.29e-35: 151: 12.75
+	Hs
		1040286 SPTN1_HUMAN (2-1232): 6.72e-45: 182: 21.48		DYST_HUMAN (7-157): 1.51e-32: 142: 19.87
+	Hs
		637525 PLEC_HUMAN (1-1338): 7.59e-40: 166: 8.88		FLNA_HUMAN (16-468): 1.29e-35: 151: 12.75
+	Hs
		1040296 PLEC_HUMAN (1-1338): 7.59e-40: 166: 8.88		DYST_HUMAN (7-157): 1.51e-32: 142: 19.87
+	Hs
		1117543 SPTN1_HUMAN (2-1232): 6.72e-45: 182: 21.48		PCLO_HUMAN (867-1704): 8.75e-14: 79.9: 10.28
+	Hs
		1040405 MACF1_HUMAN (477-2365): 5.17e-23: 110: 9.15		DYST_HUMAN (7-157): 1.51e-32: 142: 19.87
+	Hs
		1143211 PLEC_HUMAN (1-1338): 7.59e-40: 166: 8.88		CTTB2_HUMAN (37-570): 5.5e-10: 67.2: 10.51
+	Hs
		1143196 PLEC_HUMAN (1-1338): 7.59e-40: 166: 8.88		KMT2C_HUMAN (272-1191): 6.26e-09: 64: 10.52
+	Hs
		224619 ACTN4_HUMAN (1821-2158): 1.76e-13: 78.6: 22.87		FLNA_HUMAN (16-468): 1.29e-35: 151: 12.75
+	Dm
		612402 ACTN_DROME (678-1113): 1.62e-18: 95.1: 14.44		FLNA_DROME (14-300): 1.82e-29: 131: 14.98
+	Ce
		109074 G4S034_CAEEL (2-489): 5.35e-14: 80.9: 19.76		G5ECP9_CAEEL (23-161): 8.47e-34: 145: 24.14
+	Hs
		555729 ACTN1_HUMAN (4-364): 2.81e-22: 107: 16.32		TITIN_HUMAN (608-1598): 2.2e-10: 68.7: 8.21
+	Hs
		547485 DMD_HUMAN (1-894): 5.32e-16: 87.4: 12.58		TENS1_HUMAN (119-1243): 3.3e-14: 81.3: 9.21