HitPredict

Interactor 1: G4S034 (G4S034)
Spectrin alpha chain
Gene: spc-1

Interactor 2: G5ECP9 (G5ECP9)
Spectrin beta chain
Gene: vab-10

Species: Caenorhabditis elegans

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	31462781
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	CH~EF-hand_7, CH~EFhand_Ca_insen, CH~Spectrin, SH3_10~Spectrin
Common GO terms	GO:0051015 - actin filament binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2427 Ce			1 3424
+	Ce
		109076 G4S034_CAEEL (1-2427): 8.09e-175: 598: 100.00		G5EG85_CAEEL (278-821): 2.31e-16: 88.9: 14.16
+	Hs
		224600 ACTN4_HUMAN (1940-2425): 1.45e-72: 265: 33.13		ACTN1_HUMAN (13-766): 2.95e-88: 312: 21.30
+	Hs
		73649 ACTN4_HUMAN (1940-2425): 1.45e-72: 265: 33.13		B2R8Y4_HUMAN (28-770): 1.01e-81: 293: 21.37
+	Hs
		224699 ACTN4_HUMAN (1940-2425): 1.45e-72: 265: 33.13		ACTN3_HUMAN (28-770): 4.49e-81: 291: 21.50
+	Hs
		1028730 SPTB2_HUMAN (1-948): 7.29e-48: 192: 21.87		SPTB2_HUMAN (7-2073): 4.72e-99: 361: 15.09
+	Hs
		540251 SPTN1_HUMAN (2-1491): 5.33e-42: 172: 17.65		SPTB1_HUMAN (13-1770): 2.05e-105: 381: 17.29
+	Mm
		1223935 SPTB2_MOUSE (1-859): 8.06e-48: 192: 23.32		SPTB2_MOUSE (7-2082): 6.72e-99: 360: 15.12
+	Hs
		1028762 SPTN1_HUMAN (2-1491): 5.33e-42: 172: 17.65		SPTB2_HUMAN (7-2073): 4.72e-99: 361: 15.09
+	Hs
		174744 SPTB2_HUMAN (1-948): 7.29e-48: 192: 21.87		SPTN2_HUMAN (22-2154): 5.52e-83: 308: 15.50
+	Hs
		1028869 SPTB2_HUMAN (1-948): 7.29e-48: 192: 21.87		SPTN4_HUMAN (25-2349): 6.23e-81: 301: 13.21
+	Rn
		1251028 Q6XD99_RAT (1-859): 3.6e-41: 170: 21.93		ACTN1_RAT (13-766): 2.38e-88: 313: 21.43
+	Hs
		174755 SPTN1_HUMAN (2-1491): 5.33e-42: 172: 17.65		SPTN2_HUMAN (22-2154): 5.52e-83: 308: 15.50
+	Hs
		224550 ACTN4_HUMAN (1940-2425): 1.45e-72: 265: 33.13		ACTN4_HUMAN (41-365): 1.28e-55: 214: 40.00
+	Hs
		1117474 SPTN1_HUMAN (2-1491): 5.33e-42: 172: 17.65		SPTN4_HUMAN (25-2349): 6.23e-81: 301: 13.21
+	Dm
		1028094 SPTCB_DROME (32-1019): 2.58e-57: 223: 20.65		Q9VZQ3_DROME (292-1512): 4.38e-15: 84.9: 13.13
+	Hs
		1143304 PLEC_HUMAN (1-1318): 2.06e-41: 171: 10.01		MACF1_HUMAN (233-2276): 1.35e-22: 109: 9.55
+	Hs
		1040286 SPTN1_HUMAN (2-1491): 5.33e-42: 172: 17.65		DYST_HUMAN (263-1364): 1.08e-20: 103: 10.43
+	Hs
		1040296 PLEC_HUMAN (1-1318): 2.06e-41: 171: 10.01		DYST_HUMAN (263-1364): 1.08e-20: 103: 10.43
+	Hs
		1117369 SPTN1_HUMAN (2-1491): 5.33e-42: 172: 17.65		PLEC_HUMAN (2147-2881): 1.73e-09: 66.6: 10.76
+	Hs
		1143126 PLEC_HUMAN (1-1318): 2.06e-41: 171: 10.01		PLEC_HUMAN (2147-2881): 1.73e-09: 66.6: 10.76