HitPredict

Interactor 1: SPTCB (Q00963)
Spectrin beta chain
Gene: beta-Spec

Interactor 2: SICK (Q9VIQ9)
Protein sickie
Gene: SICK

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	36095217
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	CH~CH, CH~Spectrin
Common GO terms	GO:0007409 - axonogenesis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2291 Dm			1 2197
+	Dm
		612406 ACTN_DROME (28-760): 2.9e-100: 348: 31.50		SICK_DROME (1-2197): 0: 1198: 100.00
+	Dm
		561597 SPTCA_DROME (219-1310): 1.3e-35: 151: 19.10		SICK_DROME (1-2197): 0: 1198: 100.00
+	Hs
		637462 SPTB2_HUMAN (1-2262): 0: 630: 54.97		FLNA_HUMAN (16-468): 1.29e-35: 151: 12.75
+	Hs
		1028813 SPTB2_HUMAN (1-2262): 0: 630: 54.97		NAV2_HUMAN (23-1397): 9.97e-27: 122: 13.39
+	Hs
		224619 ACTN4_HUMAN (49-741): 4.05e-121: 409: 37.40		FLNA_HUMAN (16-468): 1.29e-35: 151: 12.75
+	Dm
		612402 ACTN_DROME (28-760): 2.9e-100: 348: 31.50		FLNA_DROME (14-300): 1.82e-29: 131: 14.98
+	Hs
		224763 ACTN4_HUMAN (49-741): 4.05e-121: 409: 37.40		TITIN_HUMAN (608-1598): 2.2e-10: 68.7: 8.21
+	Hs
		555729 ACTN1_HUMAN (22-772): 4.19e-89: 314: 32.47		TITIN_HUMAN (608-1598): 2.2e-10: 68.7: 8.21
+	Hs
		637503 SPTN1_HUMAN (915-2281): 9.49e-59: 228: 19.52		FLNA_HUMAN (16-468): 1.29e-35: 151: 12.75
+	Hs
		1040286 SPTN1_HUMAN (915-2281): 9.49e-59: 228: 19.52		DYST_HUMAN (7-157): 1.51e-32: 142: 19.87
+	Hs
		1061541 ACTN3_HUMAN (37-773): 3.71e-83: 296: 32.41		TITIN_HUMAN (608-1598): 2.2e-10: 68.7: 8.21
+	Hs
		637525 PLEC_HUMAN (370-2161): 3.61e-47: 190: 9.32		FLNA_HUMAN (16-468): 1.29e-35: 151: 12.75
+	Hs
		1040296 PLEC_HUMAN (370-2161): 3.61e-47: 190: 9.32		DYST_HUMAN (7-157): 1.51e-32: 142: 19.87
+	Hs
		1117543 SPTN1_HUMAN (915-2281): 9.49e-59: 228: 19.52		PCLO_HUMAN (867-1704): 8.75e-14: 79.9: 10.28
+	Hs
		174704 SPTN2_HUMAN (940-2280): 4.53e-31: 136: 14.59		FLNA_HUMAN (16-468): 1.29e-35: 151: 12.75
+	Dm
		561591 SPTCA_DROME (219-1310): 1.3e-35: 151: 19.10		FLNA_DROME (14-300): 1.82e-29: 131: 14.98
+	Hs
		1143211 PLEC_HUMAN (370-2161): 3.61e-47: 190: 9.32		CTTB2_HUMAN (37-570): 5.5e-10: 67.2: 10.51
+	Ce
		109074 G4S034_CAEEL (1872-2159): 3.63e-23: 111: 18.86		G5ECP9_CAEEL (23-161): 8.47e-34: 145: 24.14
+	Hs
		1143196 PLEC_HUMAN (370-2161): 3.61e-47: 190: 9.32		KMT2C_HUMAN (272-1191): 6.26e-09: 64: 10.52
+	Hs
		862712 UTRN_HUMAN (225-2288): 5.93e-26: 120: 9.54		TENS1_HUMAN (119-1243): 3.3e-14: 81.3: 9.21