HitPredict

Interactor 1: K2C5 (P13647)
Keratin, type II cytoskeletal 5 (58 kDa cytokeratin) (Cytokeratin-5) (CK-5) (Keratin-5) (K5) (Type-II keratin Kb5)
Gene: KRT5

Interactor 2: K1C20 (P35900)
Keratin, type I cytoskeletal 20 (Cytokeratin-20) (CK-20) (Keratin-20) (K20) (Protein IT)
Gene: KRT20

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35575683
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Filament~Filament
Common GO terms	GO:0005200 - structural constituent of cytoskeleton GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005882 - intermediate filament GO:0045109 - intermediate filament organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 590 Hs			1 424
+	Hs
		551539 K2C3_HUMAN (140-484): 3.96e-178: 519: 78.10		K1C20_HUMAN (1-424): 8.19e-156: 448: 100.00
+	Hs
		436777 K2C3_HUMAN (140-484): 3.96e-178: 519: 78.10		K1C18_HUMAN (1-415): 1.84e-141: 412: 44.03
+	Hs
		551569 K2C3_HUMAN (140-484): 3.96e-178: 519: 78.10		K1C27_HUMAN (60-423): 3.59e-141: 412: 48.66
+	Hs
		385045 K2C3_HUMAN (140-484): 3.96e-178: 519: 78.10		K1C14_HUMAN (68-418): 1.21e-138: 406: 54.80
+	Hs
		551535 K2C3_HUMAN (140-484): 3.96e-178: 519: 78.10		K1C15_HUMAN (69-420): 4.32e-135: 396: 52.13
+	Hs
		551570 K2C3_HUMAN (140-484): 3.96e-178: 519: 78.10		K1C26_HUMAN (1-423): 7.85e-135: 396: 40.93
+	Hs
		551568 K2C3_HUMAN (140-484): 3.96e-178: 519: 78.10		K1C28_HUMAN (4-423): 4.92e-111: 335: 41.71
+	Hs
		475506 K2C3_HUMAN (140-484): 3.96e-178: 519: 78.10		K1C19_HUMAN (59-378): 1.35e-103: 314: 55.63
+	Hs
		551531 K2C3_HUMAN (140-484): 3.96e-178: 519: 78.10		K1C13_HUMAN (63-380): 5.81e-102: 312: 56.74
+	Hs
		476258 K2C3_HUMAN (140-484): 3.96e-178: 519: 78.10		K1C16_HUMAN (66-387): 5.08e-100: 308: 56.52
+	Hs
		341729 K2C3_HUMAN (140-484): 3.96e-178: 519: 78.10		K2C75_HUMAN (32-393): 2.49e-92: 290: 25.28
+	Hs
		551557 K2C3_HUMAN (140-484): 3.96e-178: 519: 78.10		K1H1_HUMAN (66-378): 4.95e-94: 290: 50.48
+	Hs
		551558 K2C3_HUMAN (140-484): 3.96e-178: 519: 78.10		K1C24_HUMAN (65-411): 1.59e-92: 290: 47.61
+	Hs
		551554 K2C3_HUMAN (140-484): 3.96e-178: 519: 78.10		KT33B_HUMAN (66-380): 2.94e-92: 285: 49.84
+	Hs
		300291 K2C3_HUMAN (140-484): 3.96e-178: 519: 78.10		KRT34_HUMAN (66-380): 5.38e-92: 284: 49.52
+	Hs
		300547 K2C3_HUMAN (140-484): 3.96e-178: 519: 78.10		KRT36_HUMAN (2-424): 7.12e-83: 263: 43.69
+	Hs
		551532 K2C3_HUMAN (140-484): 3.96e-178: 519: 78.10		K2C5_HUMAN (35-384): 5.13e-81: 262: 25.57
+	Hs
		551555 K2C3_HUMAN (140-484): 3.96e-178: 519: 78.10		K1H2_HUMAN (12-393): 6.36e-82: 260: 43.72
+	Hs
		385226 K2C3_HUMAN (140-484): 3.96e-178: 519: 78.10		K2C6A_HUMAN (35-397): 7.14e-80: 258: 24.11
+	Hs
		551578 K2C3_HUMAN (140-484): 3.96e-178: 519: 78.10		KRT35_HUMAN (2-395): 1.71e-80: 256: 44.36