HitPredict

Interactor 1: HLAE (P13747)
HLA class I histocompatibility antigen, alpha chain E (MHC class I antigen E) [Cleaved into: Soluble HLA class I histocompatibility antigen, alpha chain E (sHLA-E)]
Gene: HLA-E

Interactor 2: NKG2C (P26717)
NKG2-C type II integral membrane protein (CD159 antigen-like family member C) (NK cell receptor C) (NKG2-C-activating NK receptor) (CD antigen CD159c)
Gene: KLRC2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	18083576
Identification Methods	surface plasmon resonance
Interaction Type	physical association

Property	Details
Interacting Pfam domains	C1-set~Lectin_C, Lectin_C~MHC_I
Common GO terms	GO:0002250 - adaptive immune response GO:0005886 - plasma membrane GO:0009897 - external side of plasma membrane GO:0045954 - positive regulation of natural killer cell mediated cytotoxicity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 358 Hs			1 231
+	Hs
		379884 HLAB_HUMAN (1-354): 1.41e-155: 442: 77.40		NKG2A_HUMAN (1-231): 4.44e-63: 198: 75.11
+	Hs
		607347 HLAG_HUMAN (1-335): 1.06e-154: 439: 76.72		NKG2A_HUMAN (1-231): 4.44e-63: 198: 75.11
+	Hs
		62087 HLAA_HUMAN (1-354): 1.53e-173: 488: 78.81		KLRG2_HUMAN (108-229): 1.28e-41: 147: 23.58
+	Hs
		568036 HLAE_HUMAN (17-358): 7.03e-150: 428: 100.00		NKG2A_HUMAN (1-231): 4.44e-63: 198: 75.11
+	Hs
		409464 HLAA_HUMAN (1-354): 1.53e-173: 488: 78.81		CLC2B_HUMAN (80-231): 7.22e-40: 136: 23.38
+	Hs
		409536 HLAA_HUMAN (1-354): 1.53e-173: 488: 78.81		CLC4E_HUMAN (72-229): 1.07e-38: 135: 15.64
+	Hs
		380019 HLAB_HUMAN (1-354): 1.41e-155: 442: 77.40		KLRD1_HUMAN (69-231): 1.18e-42: 144: 31.98
+	Hs
		380188 HLAB_HUMAN (1-354): 1.41e-155: 442: 77.40		CLC4E_HUMAN (72-229): 1.07e-38: 135: 15.64
+	Hs
		62089 HLAC_HUMAN (1-354): 1.59e-149: 427: 74.65		KLRG2_HUMAN (108-229): 1.28e-41: 147: 23.58
+	Hs
		568059 HLAE_HUMAN (17-358): 7.03e-150: 428: 100.00		KLRD1_HUMAN (69-231): 1.18e-42: 144: 31.98
+	Hs
		520827 HLAC_HUMAN (1-354): 1.59e-149: 427: 74.65		KLRD1_HUMAN (69-231): 1.18e-42: 144: 31.98
+	Hs
		568076 HLAE_HUMAN (17-358): 7.03e-150: 428: 100.00		CLC2B_HUMAN (80-231): 7.22e-40: 136: 23.38
+	Hs
		520947 HLAC_HUMAN (1-354): 1.59e-149: 427: 74.65		CLC2B_HUMAN (80-231): 7.22e-40: 136: 23.38
+	Hs
		521046 HLAC_HUMAN (1-354): 1.59e-149: 427: 74.65		CLC4E_HUMAN (72-229): 1.07e-38: 135: 15.64
+	Hs
		719719 HLAF_HUMAN (1-345): 4.26e-145: 415: 72.75		CL12B_HUMAN (109-229): 1.73e-41: 144: 29.77
+	Hs
		719754 HLAF_HUMAN (1-345): 4.26e-145: 415: 72.75		CLC2D_HUMAN (71-229): 1.06e-40: 139: 22.98
+	Hs
		719730 HLAF_HUMAN (1-345): 4.26e-145: 415: 72.75		CLC2B_HUMAN (80-231): 7.22e-40: 136: 23.38
+	Hs
		719759 HLAF_HUMAN (1-345): 4.26e-145: 415: 72.75		CLC4E_HUMAN (72-229): 1.07e-38: 135: 15.64
+	Hs
		688605 HMR1_HUMAN (6-347): 5.15e-111: 328: 37.39		NKG2A_HUMAN (1-231): 4.44e-63: 198: 75.11
+	Hs
		607425 HLAG_HUMAN (1-335): 1.06e-154: 439: 76.72		MRC2_HUMAN (129-227): 3.07e-11: 64.4: 14.95