HitPredict

Interactor 1: PTC (P18502)
Protein patched (Hedgehog receptor)
Gene: PTC

Interactor 2: SUDX (Q9Y0H4)
E3 ubiquitin-protein ligase Su(dx) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase Su(dx)) (Protein suppressor of deltex)
Gene: Su(dx)

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.57	0.60	0.586

Property	Details
Experiments	24302888, 29438012
Identification Methods	two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0045879 - negative regulation of smoothened signaling pathway
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 1286 Dm			1 949
+	Dm
		577405 PTC_DROME (1-1286): 0: 1295: 100.00		NEDD4_DROME (12-947): 0: 767: 29.18
+	Hs
		1044412 PTC1_HUMAN (24-1261): 0: 1165: 37.25		ITCH_HUMAN (34-949): 0: 882: 49.02
+	Hs
		1044434 PTC1_HUMAN (24-1261): 0: 1165: 37.25		WWP1_HUMAN (27-949): 0: 858: 51.42
+	Hs
		125442 PTC1_HUMAN (24-1261): 0: 1165: 37.25		WWP2_HUMAN (34-949): 0: 844: 52.01
+	Hs
		1044417 PTC1_HUMAN (24-1261): 0: 1165: 37.25		NED4L_HUMAN (45-946): 0: 812: 32.00
+	Hs
		808120 PTC1_HUMAN (24-1261): 0: 1165: 37.25		NEDD4_HUMAN (120-946): 0: 712: 33.81
+	Dm
		577410 PTC_DROME (1-1286): 0: 1295: 100.00		Q9VXR3_DROME (415-947): 8.04e-161: 525: 33.09
+	Hs
		168027 NPC1_HUMAN (59-1111): 0: 736: 18.69		WWP1_HUMAN (27-949): 0: 858: 51.42
+	Hs
		168007 NPC1_HUMAN (59-1111): 0: 736: 18.69		NED4L_HUMAN (45-946): 0: 812: 32.00
+	Dm
		577378 PTC_DROME (1-1286): 0: 1295: 100.00		SMUF1_DROME (42-560): 2.72e-42: 169: 14.26
+	Hs
		167863 NPC1_HUMAN (59-1111): 0: 736: 18.69		NEDD4_HUMAN (120-946): 0: 712: 33.81
+	Hs
		1044442 PTC1_HUMAN (24-1261): 0: 1165: 37.25		SMUF1_HUMAN (37-459): 6.6e-42: 166: 15.31
+	Hs
		1044440 PTC1_HUMAN (24-1261): 0: 1165: 37.25		SMUF2_HUMAN (42-433): 6.14e-34: 141: 18.34