HitPredict

Interactor 1: PLAK (P14923)
Junction plakoglobin (Catenin gamma) (Desmoplakin III) (Desmoplakin-3)
Gene: JUP

Interactor 2: PTPRK (Q15262)
Receptor-type tyrosine-protein phosphatase kappa (Protein-tyrosine phosphatase kappa) (R-PTP-kappa) (EC 3.1.3.48)
Gene: PTPRK

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.561

Property	Details
Experiments	8663237
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0005911 - cell-cell junction GO:0005912 - adherens junction GO:0016477 - cell migration
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 745 Hs			1 1439
+	Hs
		764768 CTNB1_HUMAN (1-731): 3.13e-172: 515: 67.38		PTPRK_HUMAN (26-1439): 0: 1175: 100.00
+	Hs
		614658 CTNB1_HUMAN (1-731): 3.13e-172: 515: 67.38		PTPRA_HUMAN (714-1438): 0: 722: 32.80
+	Hs
		577734 PLAK_HUMAN (1-745): 0: 550: 100.00		PTPRJ_HUMAN (345-1438): 2.64e-111: 385: 16.25
+	Hs
		764704 CTNB1_HUMAN (1-731): 3.13e-172: 515: 67.38		PTPRJ_HUMAN (345-1438): 2.64e-111: 385: 16.25
+	Hs
		764796 CTNB1_HUMAN (1-731): 3.13e-172: 515: 67.38		PTPRO_HUMAN (1158-1433): 7.28e-91: 323: 29.79
+	Hs
		471729 CTNB1_HUMAN (1-731): 3.13e-172: 515: 67.38		PTPRC_HUMAN (169-1153): 7.79e-80: 291: 14.82
+	Hs
		522583 PLAK_HUMAN (1-745): 0: 550: 100.00		PTPRF_HUMAN (3-825): 1.83e-64: 244: 13.85
+	Mm
		705735 CTNB1_MOUSE (1-731): 6.44e-172: 514: 67.38		PTPRM_MOUSE (11-1145): 7.79e-68: 254: 12.76
+	Hs
		522605 CTNB1_HUMAN (1-731): 3.13e-172: 515: 67.38		PTPRF_HUMAN (3-825): 1.83e-64: 244: 13.85
+	Rn
		1225810 CTNB1_RAT (1-731): 2.15e-172: 516: 67.38		PTPRF_RAT (3-825): 5.86e-64: 242: 13.16
+	Mm
		59108 CTNB1_MOUSE (1-731): 6.44e-172: 514: 67.38		PTPRF_MOUSE (3-825): 1.31e-64: 244: 13.28
+	Hs
		764929 CTNB1_HUMAN (1-731): 3.13e-172: 515: 67.38		PTPRU_HUMAN (874-1148): 1.59e-48: 192: 26.67
+	Hs
		658993 CTNB1_HUMAN (1-731): 3.13e-172: 515: 67.38		PTPRG_HUMAN (902-1147): 9.58e-46: 183: 29.64
+	Hs
		659073 CTNB1_HUMAN (1-731): 3.13e-172: 515: 67.38		PTPRZ_HUMAN (898-1156): 3.31e-45: 182: 28.46
+	Mm
		504800 PLAK_MOUSE (1-745): 0: 552: 98.39		PTPRQ_MOUSE (240-945): 3.74e-20: 100: 13.10
+	Mm
		504799 CTNB1_MOUSE (1-731): 6.44e-172: 514: 67.38		PTPRQ_MOUSE (240-945): 3.74e-20: 100: 13.10
+	Dm
		616685 ARM_DROME (2-730): 2.02e-160: 487: 60.33		Q9W4F5_DROME (194-940): 7.17e-21: 102: 11.88
+	Dm
		95415 ARM_DROME (2-730): 2.02e-160: 487: 60.33		E1JJE4_DROME (194-940): 9.98e-21: 101: 11.88
+	Hs
		658810 CTNB1_HUMAN (1-731): 3.13e-172: 515: 67.38		PTPRB_HUMAN (285-938): 1.49e-09: 65: 9.30
+	Dm
		598282 ARM_DROME (2-730): 2.02e-160: 487: 60.33		PTP69_DROME (1-463): 2.94e-13: 77.3: 6.76