HitPredict

Interactor 1: DESP (P15924)
Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen)
Gene: DSP

Interactor 2: M3K8 (P41279)
Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (Cancer Osaka thyroid oncogene) (Proto-oncogene c-Cot) (Serine/threonine-protein kinase cot) (Tumor progression locus 2) (TPL-2)
Gene: MAP3K8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	14743216
Identification Methods	tandem affinity purification
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2871 Hs			1 467
+	Hs
		587626 DESP_HUMAN (1-2871): 0: 839: 100.00		KPCE_HUMAN (49-463): 1.67e-130: 396: 16.03
+	Hs
		587568 DESP_HUMAN (1-2871): 0: 839: 100.00		AKT1_HUMAN (49-447): 9.89e-132: 391: 15.66
+	Hs
		587851 DESP_HUMAN (1-2871): 0: 839: 100.00		STK24_HUMAN (144-386): 6.57e-35: 137: 34.40
+	Mm
		591067 MYH7_MOUSE (1443-2432): 1.53e-34: 148: 11.83		KPCE_MOUSE (49-463): 4.59e-130: 395: 15.80
+	Hs
		666238 PLEC_HUMAN (2198-2814): 5.42e-32: 140: 34.90		KPCL_HUMAN (116-453): 1.18e-129: 392: 15.82
+	Hs
		122910 MYH1_HUMAN (11-934): 2.46e-30: 134: 8.21		SGK1_HUMAN (101-466): 2.35e-128: 380: 19.74
+	Mm
		591040 MYH6_MOUSE (1599-2505): 1.33e-25: 119: 11.34		KPCE_MOUSE (49-463): 4.59e-130: 395: 15.80
+	Mm
		728542 PEPL_MOUSE (837-2060): 1.64e-22: 109: 11.50		AKT1_MOUSE (49-447): 2.63e-132: 392: 15.90
+	Hs
		248675 PEPL_HUMAN (427-1469): 2.83e-22: 108: 11.19		AKT1_HUMAN (49-447): 9.89e-132: 391: 15.66
+	Hs
		834738 EPIPL_HUMAN (2625-2847): 9.98e-13: 76.9: 18.52		M3K8_HUMAN (1-467): 4.55e-139: 409: 100.00
+	Hs
		556920 MYH7_HUMAN (1443-2432): 1.99e-35: 151: 11.55		STK4_HUMAN (116-419): 3.72e-103: 317: 25.89
+	Hs
		563007 MYH6_HUMAN (50-971): 6.1e-31: 136: 9.20		STK4_HUMAN (116-419): 3.72e-103: 317: 25.89
+	Hs
		556848 MYH1_HUMAN (11-934): 2.46e-30: 134: 8.21		STK4_HUMAN (116-419): 3.72e-103: 317: 25.89
+	Hs
		563052 MYH8_HUMAN (1555-2358): 2.84e-30: 134: 11.97		STK4_HUMAN (116-419): 3.72e-103: 317: 25.89
+	Hs
		1093102 SPTN1_HUMAN (235-2163): 9.1e-27: 123: 10.31		STK4_HUMAN (116-419): 3.72e-103: 317: 25.89
+	Hs
		1093205 MYH13_HUMAN (1590-2113): 3.08e-15: 84.9: 14.11		STK4_HUMAN (116-419): 3.72e-103: 317: 25.89
+	Hs
		945784 EPIPL_HUMAN (2625-2847): 9.98e-13: 76.9: 18.52		STK4_HUMAN (116-419): 3.72e-103: 317: 25.89
+	Hs
		1093167 AKAP9_HUMAN (25-614): 2.32e-12: 75.7: 9.53		STK4_HUMAN (116-419): 3.72e-103: 317: 25.89
+	Hs
		138864 AKAP9_HUMAN (25-614): 2.32e-12: 75.7: 9.53		STK25_HUMAN (142-436): 5.7e-103: 315: 30.80
+	Hs
		1093204 MYH2_HUMAN (7-467): 3.13e-11: 71.9: 7.17		STK4_HUMAN (116-419): 3.72e-103: 317: 25.89