Protein: M3K8
Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (Cancer Osaka thyroid oncogene) (Proto-oncogene c-Cot) (Serine/threonine-protein kinase cot) (Tumor progression locus 2) (TPL-2)

Gene: M3K8, MAP3K8
Organism: Homo sapiens
Interactions: 41
UniProt ID: P41279

Gene Ontology (top 5):
GO:0000165 - MAPK cascade
GO:0000287 - magnesium ion binding
GO:0004674 - protein serine/threonine kinase activity
GO:0004709 - MAP kinase kinase kinase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

626112

NFKB1
Nuclear factor NF-kappa-B p105 subunit

10

15

Small-scale

0.982

High

834742

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

3

19

Small-scale

0.840

High

834736

M3K8
Mitogen-activated protein kinase kinase kinase 8

3

19

Small-scale

0.805

High

834740

NFKB2
Nuclear factor NF-kappa-B p100 subunit

2

15

High-throughput

0.802

High

468146

HS90B
Heat shock protein HSP 90-beta

2

20

High-throughput

0.776

High

461238

HS90A
Heat shock protein HSP 90-alpha

2

20

High-throughput

0.754

High

177815

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

20

Small-scale

0.747

High

834751

TNIP2
TNFAIP3-interacting protein 2

5

1

Small-scale

0.727

High

728083

AKT1
RAC-alpha serine/threonine-protein kinase

1

16

Small-scale

0.724

High

834743

TF65
Transcription factor p65

5

12

Small-scale

0.720

High

834750

KSR2
Kinase suppressor of Ras 2

1

20

Small-scale

0.665

High

834753

M3K14
Mitogen-activated protein kinase kinase kinase 14

1

17

Small-scale

0.665

High

834737

MP2K4
Dual specificity mitogen-activated protein kinase kinase 4

1

18

Small-scale

0.647

High

612917

EGR1
Early growth response protein 1

1

5

High-throughput

0.618

High

834749

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

1

19

Small-scale

0.618

High

834748

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

1

Small-scale

0.570

High

355155

ACL6A
Actin-like protein 6A

1

6

High-throughput

0.553

High

731043

STIP1
Stress-induced-phosphoprotein 1

1

10

High-throughput

0.541

High

834752

ACY3
N-acyl-aromatic-L-amino acid amidohydrolase

1

0

High-throughput

0.518

High

834744

REL
Proto-oncogene c-Rel

1

13

High-throughput

0.515

High

172537

XPO1
Exportin-1

1

8

High-throughput

0.479

High

407999

TBB4A
Tubulin beta-4A chain

1

16

High-throughput

0.479

High

457282

TBB5
Tubulin beta chain

1

17

High-throughput

0.479

High

534744

BIP
Endoplasmic reticulum chaperone BiP

1

20

High-throughput

0.479

High

536666

HSP7C
Heat shock cognate 71 kDa protein

1

16

High-throughput

0.479

High

587584

DESP
Desmoplakin

1

20

High-throughput

0.479

High

608844

PFKAL
ATP-dependent 6-phosphofructokinase, liver type

1

3

High-throughput

0.479

High

761340

HS71L
Heat shock 70 kDa protein 1-like

1

16

High-throughput

0.479

High

801204

HSPA9
Stress-70 protein, mitochondrial

1

20

High-throughput

0.479

High

834738

EPIPL
Epiplakin

1

11

High-throughput

0.479

High

834739

CLH1
Clathrin heavy chain 1

1

3

High-throughput

0.479

High

834741

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

4

High-throughput

0.479

High

834745

EF1A2
Elongation factor 1-alpha 2

1

5

High-throughput

0.479

High

834747

TRAF2
TNF receptor-associated factor 2

1

20

Small-scale

0.479

High

834754

TAB2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

1

1

Small-scale

0.479

High

834755

Q9UQC1
Heat shock protein 72

1

20

High-throughput

0.479

High

834756

RUVB1
RuvB-like 1

1

3

High-throughput

0.479

High

834757

TRAF6
TNF receptor-associated factor 6

1

20

Small-scale

0.479

High

683209

TNR5
Tumor necrosis factor receptor superfamily member 5

1

8

Small-scale

0.437

High

834746

LG3BP
Galectin-3-binding protein

1

6

High-throughput

0.437

High


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Last updated: 11Aug2025