HitPredict

Interactor 1: PHO85 (P17157)
Cyclin-dependent protein kinase PHO85 (EC 2.7.11.22) (Negative regulator of the PHO system) (Serine/threonine-protein kinase PHO85)
Gene: PHO85

Interactor 2: CCL1 (P37366)
Cyclin CCL1
Gene: CCL1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.740

Property	Details
Experiments	9032248
Identification Methods	affinity chromatography technology, pull down, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Cyclin_C_2~Pkinase, Cyclin_N~Pkinase
Common GO terms	GO:0005634 - nucleus GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 305 Sc			1 393
+	Hs
		667764 CDK2_HUMAN (4-303): 2.14e-145: 412: 54.82		CCNA1_HUMAN (57-333): 5.71e-82: 260: 15.60
+	Hs
		573751 CDK2_HUMAN (4-303): 2.14e-145: 412: 54.82		CCNB1_HUMAN (40-348): 4.32e-80: 254: 13.38
+	Hs
		325466 CDK2_HUMAN (4-303): 2.14e-145: 412: 54.82		CCNB2_HUMAN (10-349): 3.05e-79: 250: 12.09
+	Hs
		573801 CDK3_HUMAN (4-304): 5.62e-142: 403: 52.65		CCNB1_HUMAN (40-348): 4.32e-80: 254: 13.38
+	Hs
		629061 CDK2_HUMAN (4-303): 2.14e-145: 412: 54.82		CCNA2_HUMAN (9-332): 3.38e-73: 236: 15.65
+	Hs
		443152 CDK1_HUMAN (4-300): 7.72e-137: 390: 50.00		CCNB1_HUMAN (40-348): 4.32e-80: 254: 13.38
+	Hs
		325458 CDK1_HUMAN (4-300): 7.72e-137: 390: 50.00		CCNB2_HUMAN (10-349): 3.05e-79: 250: 12.09
+	Hs
		629100 CDK3_HUMAN (4-304): 5.62e-142: 403: 52.65		CCNA2_HUMAN (9-332): 3.38e-73: 236: 15.65
+	Hs
		666939 CDK2_HUMAN (4-303): 2.14e-145: 412: 54.82		CCNE1_HUMAN (19-344): 1.49e-69: 226: 12.87
+	Rn
		73333 Q6P751_RAT (4-303): 3.31e-145: 412: 54.82		B1WC54_RAT (9-347): 3.04e-69: 225: 10.96
+	Xl
		205903 CDK2_XENLA (4-304): 5.27e-144: 408: 55.30		CCNE3_XENLA (9-341): 7.67e-69: 224: 12.91
+	Hs
		666973 CDK3_HUMAN (4-304): 5.62e-142: 403: 52.65		CCNE1_HUMAN (19-344): 1.49e-69: 226: 12.87
+	Hs
		667665 CDK2_HUMAN (4-303): 2.14e-145: 412: 54.82		CCNH_HUMAN (48-392): 5.22e-65: 211: 24.51
+	Rn
		1048464 Q6P751_RAT (4-303): 3.31e-145: 412: 54.82		CCND2_RAT (71-329): 1.16e-63: 207: 12.59
+	Sc
		602550 PHO85_YEAST (1-305): 4.23e-140: 399: 100.00		SSN8_YEAST (48-362): 1.98e-68: 220: 20.62
+	Hs
		666822 CDK3_HUMAN (4-304): 5.62e-142: 403: 52.65		CCNC_HUMAN (49-361): 4.69e-66: 213: 20.54
+	Hs
		908691 CDK3_HUMAN (4-304): 5.62e-142: 403: 52.65		CCNH_HUMAN (48-392): 5.22e-65: 211: 24.51
+	Hs
		667568 CDK2_HUMAN (4-303): 2.14e-145: 412: 54.82		CCND2_HUMAN (71-334): 1.45e-61: 201: 12.32
+	Hs
		1025278 CDK3_HUMAN (4-304): 5.62e-142: 403: 52.65		CCNQ_HUMAN (121-312): 3.96e-54: 181: 17.70
+	Hs
		251498 CDK1_HUMAN (4-300): 7.72e-137: 390: 50.00		CCNT1_HUMAN (94-313): 1.25e-48: 177: 17.65