HitPredict

Interactor 1: SH321 (A4FU49)
SH3 domain-containing protein 21
Gene: SH3D21

Interactor 2: YAP1 (P46937)
Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog)
Gene: YAP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.50	0.457

Property	Details
Experiments	35044719
Identification Methods	unspecified method, phage display
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 640 Hs			1 504
+	Hs
		1121971 ARHG7_HUMAN (26-604): 5e-44: 170: 13.33		ITCH_HUMAN (3-504): 6.65e-111: 351: 15.47
+	Hs
		1394596 SH3G2_HUMAN (3-127): 3.52e-29: 121: 26.40		ITCH_HUMAN (3-504): 6.65e-111: 351: 15.47
+	Hs
		1394595 SH3G1_HUMAN (3-127): 7.07e-28: 117: 24.00		ITCH_HUMAN (3-504): 6.65e-111: 351: 15.47
+	Hs
		862411 SH3G1_HUMAN (3-127): 7.07e-28: 117: 24.00		YAP1_HUMAN (51-504): 2.56e-112: 343: 100.00
+	Hs
		131926 GRB2_HUMAN (44-123): 6.56e-20: 90.6: 35.00		WWP2_HUMAN (12-504): 1.09e-117: 368: 16.54
+	Hs
		1394597 SH3G3_HUMAN (2-129): 5.31e-24: 105: 24.22		ITCH_HUMAN (3-504): 6.65e-111: 351: 15.47
+	Hs
		131627 GRAP2_HUMAN (58-123): 1.43e-13: 74.3: 34.85		WWP2_HUMAN (12-504): 1.09e-117: 368: 16.54
+	Hs
		862134 MDC1_HUMAN (7-618): 1.71e-17: 89.4: 9.40		YAP1_HUMAN (51-504): 2.56e-112: 343: 100.00
+	Hs
		862588 CD2AP_HUMAN (18-386): 1.77e-16: 85.2: 14.91		YAP1_HUMAN (51-504): 2.56e-112: 343: 100.00
+	Hs
		292861 GRAP2_HUMAN (58-123): 1.43e-13: 74.3: 34.85		ITCH_HUMAN (3-504): 6.65e-111: 351: 15.47
+	Hs
		1154155 ITSN1_HUMAN (5-123): 4.78e-12: 71.6: 31.41		ITCH_HUMAN (3-504): 6.65e-111: 351: 15.47
+	Sc
		815579 PIN3_YEAST (63-123): 2.41e-12: 68.5: 34.43		RSP5_YEAST (3-504): 1.28e-97: 314: 15.25
+	Hs
		987756 GRB2_HUMAN (44-123): 6.56e-20: 90.6: 35.00		RHG12_HUMAN (14-441): 7.79e-69: 238: 13.76
+	Hs
		987675 GRB2_HUMAN (44-123): 6.56e-20: 90.6: 35.00		Q1RLN5_HUMAN (14-441): 4.36e-64: 224: 13.03
+	Hs
		987736 GRB2_HUMAN (44-123): 6.56e-20: 90.6: 35.00		HUWE1_HUMAN (76-504): 3.07e-59: 213: 10.09
+	Hs
		269601 SRGP2_HUMAN (1-438): 2.13e-37: 151: 13.70		MAGI1_HUMAN (69-305): 3.34e-38: 151: 18.32
+	Hs
		1429038 CD2AP_HUMAN (18-386): 1.77e-16: 85.2: 14.91		WWTR1_HUMAN (39-504): 6.42e-58: 199: 39.66
+	Hs
		215950 SYNJ1_HUMAN (126-553): 2.53e-11: 69.4: 10.07		WWTR1_HUMAN (39-504): 6.42e-58: 199: 39.66
+	Sc
		1042243 PIN3_YEAST (63-123): 2.41e-12: 68.5: 34.43		TOM1_YEAST (260-504): 8.95e-40: 156: 12.10
+	Hs
		1352629 SH3R3_HUMAN (9-567): 1.85e-11: 69.6: 11.11		MAGI1_HUMAN (69-305): 3.34e-38: 151: 18.32