HitPredict

Interactor 1: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Interactor 2: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 0.60 0.768

The method score is based on:

Property Details
Experiments 36720192, 8943292, 12393469, 10962563, 9988765, 16289966, 19380743, 9617486, 18835194, 22974441, 25814554, 31980649, 9461587, 9178909, 33961781, 9129019, 8626404, 8683103, 9416834, 8524328 and 7 others

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Identification Methods affinity chromatography technology, unspecified method, two hybrid, pull down, experimental interaction detection, tandem affinity purification, anti bait coimmunoprecipitation, two hybrid array, validated two hybrid, anti tag coimmunoprecipitation and 1 others

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Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0001784 - phosphotyrosine residue binding
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0017124 - SH3 domain binding
GO:0030971 - receptor tyrosine kinase binding
and 2 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 906
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Last updated: 11Aug2025