HitPredict

Interactor 1: CBL (P22682)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Interactor 2: PTN11 (P35235)
Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2)
Gene: Ptpn11

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	9393882, 23374343
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001784 - phosphotyrosine residue binding GO:0005829 - cytosol GO:0051897 - positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 913 Mm			1 593
+	Hs
		651292 CBL_HUMAN (1-913): 0: 870: 90.83		PTN11_HUMAN (1-593): 0: 583: 99.49
+	Hs
		651171 CBL_HUMAN (1-913): 0: 870: 90.83		PTN6_HUMAN (6-593): 3.77e-178: 518: 54.79
+	Mm
		767014 CBLB_MOUSE (23-907): 0: 800: 46.50		PTN11_MOUSE (1-593): 0: 582: 100.00
+	Hs
		1053655 CBLB_HUMAN (23-907): 0: 794: 46.49		PTN11_HUMAN (1-593): 0: 583: 99.49
+	Mm
		711223 CBLB_MOUSE (23-907): 0: 800: 46.50		PTN6_MOUSE (6-583): 3.64e-179: 521: 55.94
+	Hs
		651152 CBL_HUMAN (1-913): 0: 870: 90.83		PTPRB_HUMAN (195-551): 6.25e-109: 361: 30.73
+	Hs
		651468 CBL_HUMAN (1-913): 0: 870: 90.83		PTN22_HUMAN (222-566): 7.86e-105: 336: 30.35
+	Mm
		449212 CBL_MOUSE (1-913): 0: 900: 100.00		PTPRC_MOUSE (33-576): 6.85e-75: 261: 18.59
+	Hs
		471724 CBL_HUMAN (1-913): 0: 870: 90.83		PTPRC_HUMAN (33-565): 1.22e-77: 269: 17.86
+	Hs
		651334 CBL_HUMAN (1-913): 0: 870: 90.83		PTPRK_HUMAN (35-524): 2.21e-65: 234: 18.90
+	Hs
		651153 CBL_HUMAN (1-913): 0: 870: 90.83		PTPRG_HUMAN (36-527): 1.4e-54: 202: 16.05
+	Hs
		611197 HUWE1_HUMAN (435-884): 3.99e-12: 73: 17.38		PTN1_HUMAN (232-541): 9.08e-104: 322: 31.31
+	Hs
		705710 HUWE1_HUMAN (435-884): 3.99e-12: 73: 17.38		PTPRM_HUMAN (35-525): 5.49e-63: 227: 19.25
+	Hs
		659086 ANR11_HUMAN (415-912): 6.36e-11: 68.8: 13.58		PTPRZ_HUMAN (36-537): 2.76e-60: 219: 16.38