HitPredict

Interactor 1: MCM3 (P25206)
DNA replication licensing factor MCM3 (EC 3.6.4.12) (DNA polymerase alpha holoenzyme-associated protein P1) (P1-MCM3)
Gene: MCM3

Interactor 2: SLD5 (Q99LZ3)
DNA replication complex GINS protein SLD5 (GINS complex subunit 4) [Cleaved into: DNA replication complex GINS protein SLD5, N-terminally processed]
Gene: Gins4

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	33590678, 35920641
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	MCM_N~Sld5
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0071162 - CMG complex
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 812 Mm			1 223
+	Hs
		669989 MCM3_HUMAN (1-812): 0: 930: 92.64		SLD5_HUMAN (1-223): 5.17e-91: 268: 87.89
+	Dm
		1469203 MCM3_DROME (12-812): 0: 869: 60.61		Q9VBI1_DROME (19-223): 2.48e-68: 211: 39.02
+	Mm
		1021120 MCM2_MOUSE (1-726): 0: 723: 29.42		SLD5_MOUSE (1-223): 2.37e-94: 277: 100.00
+	Hs
		888289 MCM2_HUMAN (1-726): 0: 720: 29.56		SLD5_HUMAN (1-223): 5.17e-91: 268: 87.89
+	Hs
		756035 MCM5_HUMAN (9-737): 0: 703: 28.67		SLD5_HUMAN (1-223): 5.17e-91: 268: 87.89
+	Mm
		1021134 MCM6_MOUSE (2-778): 0: 669: 26.92		SLD5_MOUSE (1-223): 2.37e-94: 277: 100.00
+	Hs
		1128268 MCM6_HUMAN (2-778): 0: 659: 26.56		SLD5_HUMAN (1-223): 5.17e-91: 268: 87.89
+	Hs
		755777 MCM4_HUMAN (9-745): 0: 659: 27.81		SLD5_HUMAN (1-223): 5.17e-91: 268: 87.89
+	Dm
		887803 MCM2_DROME (3-726): 0: 689: 31.66		Q9VBI1_DROME (19-223): 2.48e-68: 211: 39.02
+	Dm
		1469190 MCM5_DROME (2-738): 0: 680: 27.99		Q9VBI1_DROME (19-223): 2.48e-68: 211: 39.02
+	Sc
		664465 MCM3_YEAST (45-812): 0: 674: 40.92		SLD5_YEAST (14-223): 7.25e-62: 196: 22.53
+	Sc
		713032 MCM2_YEAST (2-668): 0: 670: 31.09		SLD5_YEAST (14-223): 7.25e-62: 196: 22.53
+	Sc
		721410 MCM4_YEAST (9-746): 0: 660: 27.90		SLD5_YEAST (14-223): 7.25e-62: 196: 22.53
+	Dm
		1176010 MCM4_DROME (9-749): 0: 643: 27.23		Q9VBI1_DROME (19-223): 2.48e-68: 211: 39.02
+	Mm
		1223394 MCM7_MOUSE (98-674): 2.84e-84: 285: 36.64		SLD5_MOUSE (1-223): 2.37e-94: 277: 100.00
+	Hs
		756323 MCM7_HUMAN (92-652): 2.51e-84: 285: 36.97		SLD5_HUMAN (1-223): 5.17e-91: 268: 87.89
+	Sc
		794096 MCM7_YEAST (20-672): 6.78e-90: 303: 34.58		SLD5_YEAST (14-223): 7.25e-62: 196: 22.53
+	Sc
		713296 MCM5_YEAST (8-650): 6.38e-87: 293: 30.89		SLD5_YEAST (14-223): 7.25e-62: 196: 22.53