Protein: MCM3
DNA replication licensing factor MCM3 (EC 3.6.4.12) (Minichromosome maintenance protein 3)

Gene: MCM3
Organism: Saccharomyces cerevisiae S288C
Interactions: 110
UniProt ID: P24279

Gene Ontology (top 5):
GO:0000727 - double-strand break repair via break-induced replication
GO:0000781 - chromosome, telomeric region
GO:0003682 - chromatin binding
GO:0003688 - DNA replication origin binding
GO:0003697 - single-stranded DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

664417

MCM5
Minichromosome maintenance protein 5

24

20

Small-scale

0.990

High

664418

MCM4
DNA replication licensing factor MCM4

21

20

Small-scale

0.987

High

664432

MCM7
DNA replication licensing factor MCM7

19

20

Small-scale

0.986

High

664472

CDC45
Cell division control protein 45

19

15

Small-scale

0.985

High

664416

MCM2
DNA replication licensing factor MCM2

16

20

Small-scale

0.985

High

664465

SLD5
DNA replication complex GINS protein SLD5

19

15

Small-scale

0.984

High

664450

MCM6
DNA replication licensing factor MCM6

9

20

Small-scale

0.970

High

664479

PSF1
DNA replication complex GINS protein PSF1

7

11

Small-scale

0.957

High

664446

CDT1
Cell division cycle protein CDT1

6

3

Small-scale

0.946

High

664439

PSF2
DNA replication complex GINS protein PSF2

6

10

Small-scale

0.939

High

664474

PSF3
DNA replication complex GINS protein PSF3

4

9

Small-scale

0.885

High

642006

DPOE
DNA polymerase epsilon catalytic subunit A

3

11

Small-scale

0.834

High

664426

ORC2
Origin recognition complex subunit 2

2

9

Small-scale

0.778

High

479251

CDC6
Cell division control protein 6

2

20

Small-scale

0.768

High

664463

CTF4
DNA polymerase alpha-binding protein

9

9

Small-scale

0.745

High

664421

MCM10
Minichromosome maintenance protein 10

7

12

Small-scale

0.741

High

664405

MCM3
DNA replication licensing factor MCM3

1

20

Small-scale

0.713

High

664412

MRC1
Mediator of replication checkpoint protein 1

5

3

Small-scale

0.709

High

364347

CDK1
Cyclin-dependent kinase 1

4

10

Small-scale

0.696

High

561289

DPOLA
DNA polymerase alpha catalytic subunit A

3

11

Small-scale

0.656

High

664451

SLD3
DNA replication regulator SLD3

3

3

Small-scale

0.655

High

440899

CDC7
Cell division control protein 7

3

20

Small-scale

0.651

High

664458

ORC1
Origin recognition complex subunit 1

1

20

Small-scale

0.647

High

664454

TOF1
Topoisomerase 1-associated factor 1

2

9

Small-scale

0.611

High

664473

DIA2
Protein DIA2

2

3

Small-scale

0.611

High

647697

RFA1
Replication factor A protein 1

2

7

Small-scale

0.595

High

664481

CMR1
DNA damage-binding protein CMR1

2

8

High-throughput

0.586

High

664406

DPB2
DNA polymerase epsilon subunit B

2

3

Small-scale

0.584

High

664430

DEF1
RNA polymerase II degradation factor 1

2

4

High-throughput

0.584

High

664467

CSM3
Chromosome segregation in meiosis protein 3

2

3

Small-scale

0.584

High

525973

HSP72
Heat shock protein SSA2

2

17

High-throughput

0.571

High

543885

SSB1
Ribosome-associated molecular chaperone SSB1

2

18

High-throughput

0.571

High

664429

SPT10
Protein SPT10

2

3

High-throughput

0.571

High

664438

ATAD2
ATPase histone chaperone YTA7

2

6

High-throughput

0.571

High

664460

H3
Histone H3

2

20

High-throughput

0.571

High

664462

CDC14
Tyrosine-protein phosphatase CDC14

1

9

Small-scale

0.561

High

444743

SIR2
NAD-dependent histone deacetylase SIR2

1

12

Small-scale

0.552

High

664437

SSB2
Ribosome-associated molecular chaperone SSB2

2

18

High-throughput

0.552

High

664475

SMT3
Ubiquitin-like protein SMT3

1

7

Small-scale

0.515

High

441044

KAPA
cAMP-dependent protein kinase type 1

1

3

High-throughput

0.501

High

599328

FUS3
Mitogen-activated protein kinase FUS3

1

10

High-throughput

0.501

High

664407

CG22
G2/mitotic-specific cyclin-2

1

5

Small-scale

0.501

High

664420

DBF4
DDK kinase regulatory subunit DBF4

1

3

Small-scale

0.501

High

664423

IME2
Meiosis induction protein kinase IME2/SME1

1

17

Small-scale

0.501

High

664428

SLD2
DNA replication regulator SLD2

1

3

Small-scale

0.501

High

664445

DPB11
DNA replication regulator DPB11

1

4

Small-scale

0.501

High

664447

PTK2
Serine/threonine-protein kinase PTK2/STK2

1

8

High-throughput

0.501

High

664478

SKM1
Serine/threonine-protein kinase SKM1

1

8

High-throughput

0.501

High

664470

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

6

High-throughput

0.489

High

664434

YHJ3
Uncharacterized protein YHR033W

1

0

High-throughput

0.486

High

664436

SHU2
Suppressor of hydroxyurea sensitivity protein 2

1

3

Small-scale

0.481

High

664440

CSM2
Chromosome segregation in meiosis protein 2

1

3

Small-scale

0.481

High

664476

PSY3
Platinum sensitivity protein 3

1

3

Small-scale

0.481

High

358120

ADH1
Alcohol dehydrogenase 1

1

2

High-throughput

0.479

High

364937

KPYK1
Pyruvate kinase 1

1

5

High-throughput

0.479

High

434848

RS3
Small ribosomal subunit protein uS3

1

3

High-throughput

0.479

High

439253

PDC1
Pyruvate decarboxylase isozyme 1

1

3

High-throughput

0.479

High

518214

IF4A
ATP-dependent RNA helicase eIF4A

1

9

High-throughput

0.479

High

586427

PCNA
Proliferating cell nuclear antigen

1

3

Small-scale

0.479

High

594207

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

1

High-throughput

0.479

High

597386

EF3A
Elongation factor 3A

1

8

High-throughput

0.479

High

664414

CDC15
Cell division control protein 15

1

5

High-throughput

0.479

High

664415

TF2B
Transcription initiation factor IIB

1

4

High-throughput

0.479

High

664425

PP12
Serine/threonine-protein phosphatase PP1-2

1

1

High-throughput

0.479

High

664442

DSN1
Kinetochore-associated protein DSN1

1

2

High-throughput

0.479

High

664448

HFM1
ATP-dependent DNA helicase MER3

1

8

Small-scale

0.479

High

664449

UFD1
Ubiquitin fusion degradation protein 1

1

3

Small-scale

0.479

High

664452

CDH1
APC/C activator protein CDH1

1

11

Small-scale

0.479

High

664453

HST2
NAD-dependent protein deacetylase HST2

1

12

High-throughput

0.479

High

664455

IPI3
Pre-rRNA-processing protein IPI3

1

4

Small-scale

0.479

High

664457

APJ1
J domain-containing protein APJ1

1

5

High-throughput

0.479

High

664459

ACT
Actin

1

8

High-throughput

0.479

High

664461

SEN1
Helicase SEN1

1

3

Small-scale

0.479

High

664466

RUVB1
RuvB-like protein 1

1

3

High-throughput

0.479

High

664469

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

3

High-throughput

0.479

High

664477

RUVB2
RuvB-like protein 2

1

3

High-throughput

0.479

High

664413

CSM1
Monopolin complex subunit CSM1

1

1

Small-scale

0.470

High

664456

APC1
Anaphase-promoting complex subunit 1

1

0

High-throughput

0.460

High

558595

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.458

High

664433

NSE2
E3 SUMO-protein ligase MMS21

1

0

Small-scale

0.458

High

380978

H2B1
Histone H2B.1

1

20

High-throughput

0.445

High

381890

H4
Histone H4

1

8

High-throughput

0.445

High

392270

HSP82
ATP-dependent molecular chaperone HSP82

1

10

High-throughput

0.445

High

419612

H2A2
Histone H2A.2

1

20

High-throughput

0.445

High

448136

HAP2
Transcriptional activator HAP2

1

2

High-throughput

0.445

High

523123

HSP71
Heat shock protein SSA1

1

17

High-throughput

0.445

High

550027

RAP1
DNA-binding protein RAP1

1

2

High-throughput

0.445

High

597044

BIP
Endoplasmic reticulum chaperone BiP

1

13

High-throughput

0.445

High

645588

AFT1
Iron-regulated transcriptional activator AFT1

1

2

High-throughput

0.445

High

649912

SIN3
Transcriptional regulatory protein SIN3

1

1

High-throughput

0.445

High

664408

SIS1
Protein SIS1

1

5

High-throughput

0.445

High

664409

SWI4
Regulatory protein SWI4

1

7

High-throughput

0.445

High

664410

MAS5
Mitochondrial protein import protein MAS5

1

6

High-throughput

0.445

High

664424

HSP79
Heat shock protein homolog SSE2

1

20

High-throughput

0.445

High

664427

HSP78
Heat shock protein 78, mitochondrial

1

5

High-throughput

0.445

High

664431

SET3
SET domain-containing protein 3

1

5

High-throughput

0.445

High

664435

SSZ1
Ribosome-associated complex subunit SSZ1

1

11

High-throughput

0.445

High

664464

RSC4
Chromatin structure-remodeling complex subunit RSC4

1

15

High-throughput

0.445

High

664468

HSP7Q
Iron-sulfur cluster biogenesis chaperone, mitochondrial

1

20

High-throughput

0.445

High

664471

RSC58
Chromatin structure-remodeling complex protein RSC58

1

2

High-throughput

0.445

High

664480

CAF1A
Chromatin assembly factor 1 subunit A

1

5

High-throughput

0.445

High

664482

H2AZ
Histone H2A.Z

1

20

High-throughput

0.445

High

367902

ENO2
Enolase 2

1

5

High-throughput

0.437

High

664411

DCC1
Sister chromatid cohesion protein DCC1

1

1

Small-scale

0.437

High

664419

COPG
Coatomer subunit gamma

1

5

High-throughput

0.437

High

664422

SPT16
FACT complex subunit SPT16

1

5

High-throughput

0.437

High

664443

COPB
Coatomer subunit beta

1

5

High-throughput

0.437

High

664444

TAF1
Transcription initiation factor TFIID subunit 1

1

0

High-throughput

0.426

High

664441

DJP1
DnaJ-like protein 1

1

7

High-throughput

0.407

High


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Last updated: 11Aug2025