HitPredict

Interactor 1: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Interactor 2: IL3RB (P32927)
Cytokine receptor common subunit beta (CDw131) (GM-CSF/IL-3/IL-5 receptor common beta subunit) (CD antigen CD131)
Gene: CSF2RB

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	0.60	0.683

Property	Details
Experiments	15194700, 10704825, 8647804, 16437163
Identification Methods	affinity chromatography technology, pull down, coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 583 Hs			1 897
+	Hs
		699610 P85A_HUMAN (300-581): 8.31e-38: 151: 15.31		IL3RB_HUMAN (1-897): 0: 586: 100.00
+	Hs
		711246 SHC1_HUMAN (1-583): 0: 529: 100.00		IL2RG_HUMAN (236-547): 4.92e-50: 182: 20.12
+	Hs
		665026 SHC1_HUMAN (1-583): 0: 529: 100.00		IL4RA_HUMAN (233-881): 2.9e-46: 180: 17.16
+	Hs
		711265 SHC1_HUMAN (1-583): 0: 529: 100.00		IL6RB_HUMAN (241-441): 5.05e-46: 180: 21.53
+	Hs
		619209 SHC1_HUMAN (1-583): 0: 529: 100.00		EPOR_HUMAN (245-685): 9.72e-41: 159: 16.42
+	Mm
		593807 SHC1_MOUSE (1-583): 1.06e-180: 524: 94.51		IL2RB_MOUSE (248-718): 9.16e-39: 154: 18.06
+	Hs
		575811 SHC1_HUMAN (1-583): 0: 529: 100.00		IL2RB_HUMAN (248-745): 7.44e-37: 148: 16.00
+	Hs
		711400 SHC1_HUMAN (1-583): 0: 529: 100.00		CSF3R_HUMAN (241-594): 1.88e-31: 134: 17.47
+	Hs
		584629 P85A_HUMAN (300-581): 8.31e-38: 151: 15.31		CSF2R_HUMAN (154-480): 1.47e-71: 243: 14.45
+	Hs
		584462 VAV_HUMAN (154-578): 2.52e-55: 202: 11.97		PRLR_HUMAN (241-733): 4.28e-47: 180: 15.27
+	Hs
		584486 VAV_HUMAN (154-578): 2.52e-55: 202: 11.97		IL6RB_HUMAN (241-441): 5.05e-46: 180: 21.53
+	Hs
		593915 NCK1_HUMAN (360-575): 1.56e-41: 155: 18.30		IL3RA_HUMAN (170-505): 2e-60: 212: 17.70
+	Hs
		584468 VAV_HUMAN (154-578): 2.52e-55: 202: 11.97		EPOR_HUMAN (245-685): 9.72e-41: 159: 16.42
+	Hs
		728678 SHB_HUMAN (369-579): 1.33e-41: 159: 20.63		IL2RG_HUMAN (236-547): 4.92e-50: 182: 20.12
+	Hs
		473376 HCK_HUMAN (348-575): 6.63e-42: 160: 17.16		IL6RB_HUMAN (241-441): 5.05e-46: 180: 21.53
+	Hs
		699622 P85A_HUMAN (300-581): 8.31e-38: 151: 15.31		IL6RB_HUMAN (241-441): 5.05e-46: 180: 21.53
+	Hs
		619207 P85A_HUMAN (300-581): 8.31e-38: 151: 15.31		EPOR_HUMAN (245-685): 9.72e-41: 159: 16.42
+	Hs
		575828 SHB_HUMAN (369-579): 1.33e-41: 159: 20.63		IL2RB_HUMAN (248-745): 7.44e-37: 148: 16.00
+	Hs
		575809 P85A_HUMAN (300-581): 8.31e-38: 151: 15.31		IL2RB_HUMAN (248-745): 7.44e-37: 148: 16.00
+	Hs
		473464 HCK_HUMAN (348-575): 6.63e-42: 160: 17.16		CSF3R_HUMAN (241-594): 1.88e-31: 134: 17.47