Protein: IL4RA
Interleukin-4 receptor subunit alpha (IL-4 receptor subunit alpha) (IL-4R subunit alpha) (IL-4R-alpha) (IL-4RA) (CD antigen CD124) [Cleaved into: Soluble interleukin-4 receptor subunit alpha (Soluble IL-4 receptor subunit alpha) (Soluble IL-4R-alpha) (sIL4Ralpha/prot) (IL-4-binding protein) (IL4-BP)]

Gene: IL4RA, IL4R
Organism: Homo sapiens
Interactions: 49
UniProt ID: P24394

Gene Ontology (top 5):
GO:0002532 - production of molecular mediator involved in inflammatory response
GO:0002639 - positive regulation of immunoglobulin production
GO:0004896 - cytokine receptor activity
GO:0004913 - interleukin-4 receptor activity
GO:0005576 - extracellular region

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

424316

IL4
Interleukin-4

10

3

Small-scale

0.973

High

665029

IL13
Interleukin-13

6

3

Small-scale

0.941

High

665032

STAT6
Signal transducer and activator of transcription 6

5

20

Small-scale

0.710

High

658631

JAK1
Tyrosine-protein kinase JAK1

4

20

Small-scale

0.700

High

665025

PTN6
Tyrosine-protein phosphatase non-receptor type 6

4

20

Small-scale

0.680

High

665027

TYK2
Non-receptor tyrosine-protein kinase TYK2

2

20

High-throughput

0.628

High

665043

KCNT2
Potassium channel subfamily T member 2

2

3

High-throughput

0.628

High

665044

ARHG8
Neuroepithelial cell-transforming gene 1 protein

2

8

High-throughput

0.628

High

665055

PMYT1
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

2

9

High-throughput

0.628

High

665028

IL2RG
Cytokine receptor common subunit gamma

2

16

Small-scale

0.611

High

665042

RHDF2
Inactive rhomboid protein 2

2

0

High-throughput

0.602

High

665051

TR19L
Tumor necrosis factor receptor superfamily member 19L

2

0

High-throughput

0.602

High

665057

UTP6
U3 small nucleolar RNA-associated protein 6 homolog

2

0

High-throughput

0.602

High

665026

SHC1
SHC-transforming protein 1

2

20

Small-scale

0.595

High

665035

I13R1
Interleukin-13 receptor subunit alpha-1

2

16

Small-scale

0.584

High

322698

RHBT3
Rho-related BTB domain-containing protein 3

2

16

High-throughput

0.574

High

665037

GOGA2
Golgin subfamily A member 2

2

6

High-throughput

0.574

High

665038

STX5
Syntaxin-5

2

4

High-throughput

0.574

High

665045

PKHH3
Pleckstrin homology domain-containing family H member 3

2

1

High-throughput

0.574

High

665058

ZDHC9
Palmitoyltransferase ZDHHC9

2

4

High-throughput

0.574

High

169441

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

4

Small-scale

0.561

High

273307

SOCS5
Suppressor of cytokine signaling 5

1

20

Small-scale

0.561

High

335001

ARI2
E3 ubiquitin-protein ligase ARIH2

1

7

High-throughput

0.541

High

127638

TR10A
Tumor necrosis factor receptor superfamily member 10A

1

4

High-throughput

0.536

High

410628

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.536

High

665031

BMR1A
Bone morphogenetic protein receptor type-1A

1

1

High-throughput

0.536

High

665040

AVR2B
Activin receptor type-2B

1

1

High-throughput

0.536

High

665049

SHIP1
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

1

1

Small-scale

0.516

High

253299

JAK2
Tyrosine-protein kinase JAK2

1

20

Small-scale

0.515

High

665024

TNR5
Tumor necrosis factor receptor superfamily member 5

1

6

Small-scale

0.515

High

665033

JAK3
Tyrosine-protein kinase JAK3

1

20

Small-scale

0.515

High

665023

IL4RA
Interleukin-4 receptor subunit alpha

1

14

Small-scale

0.501

High

665030

IRS1
Insulin receptor substrate 1

1

9

Small-scale

0.501

High

665034

RACK1
Small ribosomal subunit protein RACK1

1

6

Small-scale

0.501

High

665036

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

20

Small-scale

0.501

High

665041

I13R2
Interleukin-13 receptor subunit alpha-2

1

18

Small-scale

0.501

High

297050

DHRS3
Short-chain dehydrogenase/reductase 3

1

2

High-throughput

0.489

High

572779

NCF1
Neutrophil cytosol factor 1

1

12

Small-scale

0.479

High

665039

GRB10
Growth factor receptor-bound protein 10

1

20

Small-scale

0.479

High

665050

KAT5
Histone acetyltransferase KAT5

1

2

Small-scale

0.479

High

665054

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

8

Small-scale

0.479

High

665056

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.479

High

665048

PIBF1
Progesterone-induced-blocking factor 1

1

0

Small-scale

0.458

High

371186

MYC
Myc proto-oncogene protein

1

5

High-throughput

0.445

High

665046

ANKL2
Ankyrin repeat and LEM domain-containing protein 2

2

0

High-throughput

0.328

High

665052

PRR11
Proline-rich protein 11

2

0

High-throughput

0.328

High

665047

DCAKD
Dephospho-CoA kinase domain-containing protein

1

0

High-throughput

0.279

Low

665053

ARL5B
ADP-ribosylation factor-like protein 5B

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025