HitPredict

Interactor 1: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Interactor 2: LCP2 (Q13094)
Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76)
Gene: LCP2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	9716598
Identification Methods	affinity chromatography technology, coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~SH2
Common GO terms	GO:0005829 - cytosol GO:0035556 - intracellular signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 583 Hs			1 533
+	Hs
		584529 VAV_HUMAN (154-578): 2.52e-55: 202: 11.97		LCP2_HUMAN (1-533): 2.39e-78: 257: 100.00
+	Mm
		699356 VAV_MOUSE (154-579): 1.91e-54: 199: 11.50		LCP2_MOUSE (1-531): 1.4e-72: 242: 80.98
+	Hs
		222071 NCK2_HUMAN (363-579): 7.09e-45: 165: 18.83		LCP2_HUMAN (1-533): 2.39e-78: 257: 100.00
+	Hs
		473410 HCK_HUMAN (348-575): 6.63e-42: 160: 17.16		LCP2_HUMAN (1-533): 2.39e-78: 257: 100.00
+	Hs
		1094303 SHB_HUMAN (369-579): 1.33e-41: 159: 20.63		LCP2_HUMAN (1-533): 2.39e-78: 257: 100.00
+	Hs
		593980 NCK1_HUMAN (360-575): 1.56e-41: 155: 18.30		LCP2_HUMAN (1-533): 2.39e-78: 257: 100.00
+	Hs
		699727 P85A_HUMAN (300-581): 8.31e-38: 151: 15.31		LCP2_HUMAN (1-533): 2.39e-78: 257: 100.00
+	Mm
		1221486 NCK1_MOUSE (360-575): 2.05e-41: 155: 18.30		LCP2_MOUSE (1-531): 1.4e-72: 242: 80.98
+	Hs
		584570 VAV_HUMAN (154-578): 2.52e-55: 202: 11.97		BLNK_HUMAN (75-520): 1.01e-33: 135: 24.28
+	Hs
		908212 BMX_HUMAN (341-582): 1.13e-38: 153: 19.69		CLNK_HUMAN (182-528): 9.86e-42: 156: 25.00
+	Hs
		699790 P85A_HUMAN (300-581): 8.31e-38: 151: 15.31		CLNK_HUMAN (182-528): 9.86e-42: 156: 25.00
+	Hs
		1357680 VAV3_HUMAN (163-579): 1.3e-43: 168: 13.50		BLNK_HUMAN (75-520): 1.01e-33: 135: 24.28
+	Hs
		222163 NCK2_HUMAN (363-579): 7.09e-45: 165: 18.83		BLNK_HUMAN (75-520): 1.01e-33: 135: 24.28
+	Hs
		594058 NCK1_HUMAN (360-575): 1.56e-41: 155: 18.30		BLNK_HUMAN (75-520): 1.01e-33: 135: 24.28
+	Hs
		699915 P85A_HUMAN (300-581): 8.31e-38: 151: 15.31		MYO16_HUMAN (44-389): 5.38e-27: 118: 14.76
+	Hs
		699803 P85A_HUMAN (300-581): 8.31e-38: 151: 15.31		TENS4_HUMAN (189-512): 1.18e-26: 116: 16.52
+	Mm
		686965 P85A_MOUSE (300-581): 1.94e-37: 149: 15.99		MYO16_MOUSE (44-439): 1.08e-20: 98.5: 13.26
+	Hs
		215903 NCK1_HUMAN (360-575): 1.56e-41: 155: 18.30		SYNJ1_HUMAN (10-452): 3.63e-12: 71.6: 11.37
+	Hs
		176246 NCK1_HUMAN (360-575): 1.56e-41: 155: 18.30		SYNJ2_HUMAN (125-443): 2.57e-09: 62.3: 11.77
+	Hs
		176248 P85A_HUMAN (300-581): 8.31e-38: 151: 15.31		SYNJ2_HUMAN (125-443): 2.57e-09: 62.3: 11.77