HitPredict

Interactor 1: B4DUB1 (B4DUB1)
cyclin-dependent kinase (EC 2.7.11.22)
Gene: B4DUB1

Interactor 2: MED14 (O60244)
Mediator of RNA polymerase II transcription subunit 14 (Activator-recruited cofactor 150 kDa component) (ARC150) (Cofactor required for Sp1 transcriptional activation subunit 2) (CRSP complex subunit 2) (Mediator complex subunit 14) (RGR1 homolog) (hRGR1) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150)
Gene: MED14

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.80	0.514

Property	Details
Experiments	28514442
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	Med14~Pkinase
Common GO terms	-
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 378 Hs			1 1454
+	Hs
		239614 CDK19_HUMAN (3-378): 1.04e-110: 334: 94.15		MED14_HUMAN (1-1454): 0: 1569: 100.00
+	Hs
		239549 CDK8_HUMAN (3-378): 1.47e-109: 330: 65.69		MED14_HUMAN (1-1454): 0: 1569: 100.00
+	Dm
		1485966 CDK8_DROME (3-248): 1.6e-97: 299: 76.42		MED14_DROME (23-1453): 0: 1167: 36.49
+	Sc
		619430 SSN3_YEAST (28-252): 3.41e-42: 156: 41.88		MED14_YEAST (2-463): 7.18e-139: 456: 18.45
+	Hs
		881573 CDK8_HUMAN (3-378): 1.47e-109: 330: 65.69		CBP_HUMAN (989-1449): 2.12e-14: 81.1: 13.58
+	Hs
		667432 CDK19_HUMAN (3-378): 1.04e-110: 334: 94.15		RPB1_HUMAN (1059-1159): 8.92e-09: 62.5: 23.30
+	Hs
		667208 CDK8_HUMAN (3-378): 1.47e-109: 330: 65.69		RPB1_HUMAN (1059-1159): 8.92e-09: 62.5: 23.30
+	Dm
		402288 CDK8_DROME (3-248): 1.6e-97: 299: 76.42		RPB1_DROME (988-1358): 9.74e-10: 65.7: 14.18
+	Hs
		691810 MK03_HUMAN (2-258): 2.88e-89: 275: 30.89		CBP_HUMAN (989-1449): 2.12e-14: 81.1: 13.58
+	Hs
		703673 MK01_HUMAN (2-256): 1.81e-89: 275: 28.79		CBP_HUMAN (989-1449): 2.12e-14: 81.1: 13.58
+	Hs
		667957 CDK2_HUMAN (1-217): 4.17e-86: 264: 34.10		CBP_HUMAN (989-1449): 2.12e-14: 81.1: 13.58
+	Dm
		823698 ERKA_DROME (2-257): 2.57e-88: 273: 27.91		CANB_DROME (1004-1196): 1.4e-10: 68.3: 23.27
+	Rn
		989635 MK01_RAT (2-256): 1.63e-89: 275: 28.79		SYNJ1_RAT (840-1229): 7.32e-09: 63: 9.79
+	Hs
		443320 CDK1_HUMAN (3-214): 3.28e-86: 265: 33.49		IF4G1_HUMAN (838-1375): 9.77e-10: 65.7: 12.70
+	Hs
		130403 CDK7_HUMAN (28-230): 1.61e-29: 118: 38.42		SPT5H_HUMAN (836-1009): 1.63e-09: 65: 10.99
+	Hs
		667216 CDK7_HUMAN (28-230): 1.61e-29: 118: 38.42		RPB1_HUMAN (1059-1159): 8.92e-09: 62.5: 23.30