Protein: MED14
Mediator of RNA polymerase II transcription subunit 14 (Glucose repression regulatory protein 1) (Mediator complex subunit 14)

Gene: MED14, RGR1
Organism: Saccharomyces cerevisiae S288C
Interactions: 81
UniProt ID: P19263

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0001093 - TFIIB-class transcription factor binding
GO:0003712 - transcription coregulator activity
GO:0005634 - nucleus
GO:0006357 - regulation of transcription by RNA polymerase II

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

619449

MED7
Mediator of RNA polymerase II transcription subunit 7

10

3

Small-scale

0.969

High

619446

MED10
Mediator of RNA polymerase II transcription subunit 10

8

3

Small-scale

0.966

High

619406

MED17
Mediator of RNA polymerase II transcription subunit 17

12

0

Small-scale

0.925

High

619455

MED4
Mediator of RNA polymerase II transcription subunit 4

7

0

Small-scale

0.910

High

619437

MED21
Mediator of RNA polymerase II transcription subunit 21

7

0

Small-scale

0.909

High

619430

SSN3
Meiotic mRNA stability protein kinase SSN3

4

3

Small-scale

0.896

High

619401

MED19
Mediator of RNA polymerase II transcription subunit 19

5

0

Small-scale

0.861

High

619425

MED31
Mediator of RNA polymerase II transcription subunit 31

3

2

High-throughput

0.830

High

619423

MED8
Mediator of RNA polymerase II transcription subunit 8

10

1

Small-scale

0.751

High

619426

MED6
Mediator of RNA polymerase II transcription subunit 6

9

3

Small-scale

0.749

High

619408

MED18
Mediator of RNA polymerase II transcription subunit 18

14

0

Small-scale

0.727

High

401875

RPB1
DNA-directed RNA polymerase II subunit RPB1

6

1

Small-scale

0.719

High

619395

MED15
Mediator of RNA polymerase II transcription subunit 15

10

0

Small-scale

0.717

High

619405

MED16
Mediator of RNA polymerase II transcription subunit 16

9

0

Small-scale

0.716

High

619411

MED9
Mediator of RNA polymerase II transcription subunit 9

8

0

Small-scale

0.714

High

619432

MED3
Mediator of RNA polymerase II transcription subunit 3

9

0

Small-scale

0.714

High

619454

MED1
Mediator of RNA polymerase II transcription subunit 1

8

0

Small-scale

0.714

High

619415

MED20
Mediator of RNA polymerase II transcription subunit 20

7

0

Small-scale

0.709

High

619451

MED2
Mediator of RNA polymerase II transcription subunit 2

7

0

Small-scale

0.706

High

619407

MED22
Mediator of RNA polymerase II transcription subunit 22

6

0

Small-scale

0.696

High

594171

RPB3
DNA-directed RNA polymerase II subunit RPB3

4

1

Small-scale

0.672

High

619403

SRB8
Mediator of RNA polymerase II transcription subunit 12

3

3

Small-scale

0.660

High

619439

MED5
Mediator of RNA polymerase II transcription subunit 5

4

0

Small-scale

0.657

High

619457

MED11
Mediator of RNA polymerase II transcription subunit 11

4

0

Small-scale

0.648

High

619404

TF2B
Transcription initiation factor IIB

3

1

Small-scale

0.642

High

470455

RPB2
DNA-directed RNA polymerase II subunit RPB2

3

1

Small-scale

0.633

High

619396

RPB4
DNA-directed RNA polymerase II subunit RPB4

3

1

Small-scale

0.633

High

440824

KIN28
Serine/threonine-protein kinase KIN28

1

0

Small-scale

0.614

High

525879

HSP72
Heat shock protein SSA2

2

1

High-throughput

0.601

High

619436

SSN8
RNA polymerase II holoenzyme cyclin-like subunit

2

2

High-throughput

0.601

High

619441

H3
Histone H3

2

2

Small-scale

0.595

High

619424

RCK1
Serine/threonine-protein kinase RCK1

1

0

High-throughput

0.586

High

619429

SSN2
Mediator of RNA polymerase II transcription subunit 13

2

0

High-throughput

0.585

High

381859

H4
Histone H4

2

0

Small-scale

0.577

High

619453

RIO1
Serine/threonine-protein kinase RIO1

2

1

High-throughput

0.571

High

619399

PSA1
Proteasome subunit alpha type-1

2

0

High-throughput

0.563

High

619416

TAF14
Transcription initiation factor TFIID subunit 14

2

0

Small-scale

0.559

High

543762

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.536

High

619438

SPT20
SAGA complex subunit SPT20

1

0

High-throughput

0.513

High

598370

TUP1
General transcriptional corepressor TUP1

1

2

Small-scale

0.479

High

585467

KCY
Uridylate kinase

1

0

High-throughput

0.458

High

619409

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

0

High-throughput

0.458

High

619410

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

619417

SPT21
Protein SPT21

1

0

High-throughput

0.458

High

619418

DEF1
RNA polymerase II degradation factor 1

1

0

High-throughput

0.458

High

619422

PLPHP
Pyridoxal phosphate homeostasis protein

1

0

High-throughput

0.458

High

619443

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

619444

IMB1
Importin subunit beta-1

1

0

High-throughput

0.458

High

619445

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.458

High

619450

BMS1
Ribosome biogenesis protein BMS1

1

0

High-throughput

0.458

High

619452

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

619456

SMC6
Structural maintenance of chromosomes protein 6

1

0

High-throughput

0.458

High

523006

HSP71
Heat shock protein SSA1

1

1

High-throughput

0.445

High

619397

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

1

Small-scale

0.445

High

619398

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

1

Small-scale

0.445

High

619414

RPB7
DNA-directed RNA polymerase II subunit RPB7

1

1

Small-scale

0.445

High

619427

TRA1
SAGA complex/NuA4 acetyltransferase complex subunit TRA1

1

1

High-throughput

0.445

High

619431

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.445

High

619442

GCN5
Histone acetyltransferase GCN5

1

3

High-throughput

0.445

High

392196

HSP82
ATP-dependent molecular chaperone HSP82

1

0

High-throughput

0.426

High

486020

TBA1
Tubulin alpha-1 chain

1

0

High-throughput

0.426

High

619400

AFT1
Iron-regulated transcriptional activator AFT1

1

0

High-throughput

0.426

High

619402

MAS5
Mitochondrial protein import protein MAS5

1

0

High-throughput

0.426

High

619428

RIX1
Pre-rRNA-processing protein RIX1

1

0

High-throughput

0.426

High

619434

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.426

High

619440

PFD4
Prefoldin subunit 4

1

0

High-throughput

0.426

High

619412

PLSC
1-acyl-sn-glycerol-3-phosphate acyltransferase

2

0

High-throughput

0.307

High

619435

YMR1
Phosphoinositide 3-phosphatase

1

0

High-throughput

0.279

Low

619447

PEX19
Peroxisomal membrane protein import receptor PEX19

1

0

High-throughput

0.265

Low

360943

CCPR
Cytochrome c peroxidase, mitochondrial

1

0

High-throughput

0.249

Low

619419

PDX3
Pyridoxamine 5'-phosphate oxidase

1

0

High-throughput

0.249

Low

619420

ARA1
D-arabinose dehydrogenase [NAD(P)+] heavy chain

1

0

High-throughput

0.249

Low

619421

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

619448

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.249

Low

364919

KPYK1
Pyruvate kinase 1

1

0

High-throughput

0.232

Low

386558

TBB
Tubulin beta chain

1

0

High-throughput

0.232

Low

394219

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.232

Low

453414

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.232

Low

591996

VATB
V-type proton ATPase subunit B

1

0

High-throughput

0.232

Low

619413

HSP78
Heat shock protein 78, mitochondrial

1

0

High-throughput

0.232

Low

619433

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025