Protein: SSN3
Meiotic mRNA stability protein kinase SSN3 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin-dependent kinase 8) (Suppressor of RNA polymerase B SRB10)

Gene: SSN3
Organism: Saccharomyces cerevisiae S288C
Interactions: 81
UniProt ID: P39073

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0004672 - protein kinase activity
GO:0004693 - cyclin-dependent protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

810653

SSN8
RNA polymerase II holoenzyme cyclin-like subunit

15

20

Small-scale

0.987

High

619430

MED14
Mediator of RNA polymerase II transcription subunit 14

4

3

Small-scale

0.896

High

448725

SNF1
Carbon catabolite-derepressing protein kinase

3

0

Small-scale

0.823

High

402004

RPB1
DNA-directed RNA polymerase II subunit RPB1

8

9

Small-scale

0.747

High

645926

DBF2
Cell cycle protein kinase DBF2

1

18

Small-scale

0.740

High

810649

RIM15
Serine/threonine-protein kinase RIM15

1

18

Small-scale

0.740

High

408415

GAL4
Regulatory protein GAL4

6

8

Small-scale

0.738

High

678810

SRB8
Mediator of RNA polymerase II transcription subunit 12

6

6

Small-scale

0.733

High

807803

SSN2
Mediator of RNA polymerase II transcription subunit 13

6

0

Small-scale

0.702

High

740407

MED17
Mediator of RNA polymerase II transcription subunit 17

6

0

Small-scale

0.698

High

585938

CSK21
Casein kinase II subunit alpha

1

19

High-throughput

0.691

High

740797

MED18
Mediator of RNA polymerase II transcription subunit 18

5

0

Small-scale

0.690

High

726214

CCR4
CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4

1

2

Small-scale

0.665

High

810679

MED1
Mediator of RNA polymerase II transcription subunit 1

4

0

Small-scale

0.660

High

810676

MED2
Mediator of RNA polymerase II transcription subunit 2

4

0

Small-scale

0.658

High

751208

MED9
Mediator of RNA polymerase II transcription subunit 9

3

1

Small-scale

0.650

High

754154

MSN2
Zinc finger protein MSN2

1

2

Small-scale

0.647

High

757623

SIP2
SNF1 protein kinase subunit beta-2

1

4

Small-scale

0.647

High

810644

SSN3
Meiotic mRNA stability protein kinase SSN3

1

17

Small-scale

0.647

High

810665

GAL83
SNF1 protein kinase subunit beta-3

1

4

Small-scale

0.647

High

810673

MED7
Mediator of RNA polymerase II transcription subunit 7

3

4

Small-scale

0.646

High

740458

MED22
Mediator of RNA polymerase II transcription subunit 22

3

0

High-throughput

0.634

High

810659

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

19

High-throughput

0.621

High

810680

MED4
Mediator of RNA polymerase II transcription subunit 4

3

0

Small-scale

0.619

High

810645

BEM2
GTPase-activating protein BEM2/IPL2

1

7

High-throughput

0.618

High

810648

MED3
Mediator of RNA polymerase II transcription subunit 3

2

1

Small-scale

0.618

High

800703

RCK1
Serine/threonine-protein kinase RCK1

1

16

High-throughput

0.618

High

804019

MED6
Mediator of RNA polymerase II transcription subunit 6

1

3

High-throughput

0.618

High

668490

MED19
Mediator of RNA polymerase II transcription subunit 19

3

0

High-throughput

0.616

High

797707

MED8
Mediator of RNA polymerase II transcription subunit 8

2

1

Small-scale

0.611

High

810668

MED10
Mediator of RNA polymerase II transcription subunit 10

2

3

Small-scale

0.611

High

395245

GCN4
General control transcription factor GCN4

2

2

Small-scale

0.595

High

598403

TUP1
General transcriptional corepressor TUP1

2

16

Small-scale

0.586

High

810650

CSK2B
Casein kinase II subunit beta

1

3

High-throughput

0.579

High

801151

MED31
Mediator of RNA polymerase II transcription subunit 31

2

4

High-throughput

0.571

High

624914

MED15
Mediator of RNA polymerase II transcription subunit 15

2

0

Small-scale

0.559

High

810654

MED21
Mediator of RNA polymerase II transcription subunit 21

2

0

Small-scale

0.559

High

810651

SIP4
Protein SIP4

1

0

Small-scale

0.549

High

807886

BFR1
Nuclear segregation protein BFR1

1

1

High-throughput

0.536

High

810647

RIO2
Serine/threonine-protein kinase RIO2

1

6

High-throughput

0.536

High

810658

NAT10
RNA cytidine acetyltransferase

1

1

High-throughput

0.536

High

810664

ERB1
Ribosome biogenesis protein ERB1

1

12

High-throughput

0.536

High

810667

TMA10
Translation machinery-associated protein 10

1

0

High-throughput

0.513

High

810671

PBP4
Protein PBP4

1

0

High-throughput

0.513

High

810672

TSR1
Ribosome biogenesis protein TSR1

1

0

High-throughput

0.513

High

795864

LSM2
LSM complex subunit LSM2

1

3

High-throughput

0.508

High

511100

YRF15
Y' element ATP-dependent helicase protein 1 copy 5

1

5

High-throughput

0.501

High

655622

TAF2
Transcription initiation factor TFIID subunit 2

1

2

Small-scale

0.501

High

777048

BDF1
Bromodomain-containing factor 1

1

20

Small-scale

0.501

High

780937

PHD1
Putative transcription factor PHD1

1

2

Small-scale

0.501

High

810652

MET7
Cystathionine gamma-synthase

1

2

High-throughput

0.501

High

810656

SGF73
SAGA complex subunit SGF73

1

1

High-throughput

0.501

High

810657

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

10

High-throughput

0.501

High

564659

STE12
Protein STE12

1

0

Small-scale

0.494

High

438695

SC160
Protein SCP160

1

12

High-throughput

0.489

High

582465

SEC23
Protein transport protein SEC23

1

2

High-throughput

0.489

High

810662

RRB1
Ribosome assembly protein RRB1

1

11

High-throughput

0.489

High

438143

NOT2
General negative regulator of transcription subunit 2

1

0

Small-scale

0.486

High

678960

NOT1
General negative regulator of transcription subunit 1

1

0

Small-scale

0.486

High

810670

CDC73
Cell division control protein 73

1

2

Small-scale

0.481

High

810666

ECM22
Sterol regulatory element-binding protein ECM22

1

0

High-throughput

0.480

High

454576

TFS2
Transcription elongation factor S-II

1

7

Small-scale

0.479

High

481625

HSP73
Heat shock protein SSA3

1

20

Small-scale

0.479

High

707111

TF2B
Transcription initiation factor IIB

1

4

High-throughput

0.479

High

806856

SKN7
Transcription factor SKN7

1

8

Small-scale

0.479

High

810660

TOM1
E3 ubiquitin-protein ligase TOM1

1

10

High-throughput

0.479

High

781870

CAF4
CCR4-associated factor 4

1

19

Small-scale

0.464

High

733541

MED16
Mediator of RNA polymerase II transcription subunit 16

1

0

High-throughput

0.458

High

757583

MED20
Mediator of RNA polymerase II transcription subunit 20

1

0

High-throughput

0.458

High

810655

MED5
Mediator of RNA polymerase II transcription subunit 5

1

0

High-throughput

0.458

High

810681

MED11
Mediator of RNA polymerase II transcription subunit 11

1

0

High-throughput

0.458

High

810675

YPQ1
Vacuolar lysine transporter YPQ1

1

1

High-throughput

0.457

High

810678

RBD2
Rhomboid-type serine protease 2

1

2

High-throughput

0.457

High

810646

SSB2
Ribosome-associated molecular chaperone SSB2

1

20

High-throughput

0.445

High

810661

GCN5
Histone acetyltransferase GCN5

1

20

High-throughput

0.445

High

810677

RIO1
Serine/threonine-protein kinase RIO1

1

6

High-throughput

0.445

High

358216

ADH1
Alcohol dehydrogenase 1

1

1

Small-scale

0.437

High

810669

BFR2
Protein BFR2

1

0

High-throughput

0.279

Low

810663

YM54
Uncharacterized protein YMR196W

1

0

High-throughput

0.261

Low

810674

CUE5
Ubiquitin-binding protein CUE5

1

0

High-throughput

0.261

Low


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Last updated: 11Aug2025