HitPredict

Interactor 1: TIE1 (P35590)
Tyrosine-protein kinase receptor Tie-1 (EC 2.7.10.1)
Gene: TIE1

Interactor 2: PSG5 (Q15238)
Pregnancy-specific beta-1-glycoprotein 5 (PS-beta-G-5) (PSBG-5) (Pregnancy-specific glycoprotein 5) (Fetal liver non-specific cross-reactive antigen 3) (FL-NCA-3)
Gene: PSG5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.55	0.80	0.668

Property	Details
Experiments	21982860
Identification Methods	pull down, surface plasmon resonance, protein array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Ig_3~fn3, V-set~fn3, Ig_2~ig, Ig_3~ig, V-set~ig
Common GO terms	-
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1138 Hs			1 335
+	Hs
		731840 PTK7_HUMAN (337-1109): 4.51e-151: 481: 20.89		CEAM8_HUMAN (1-333): 1.23e-75: 238: 57.06
+	Hs
		731832 EPHB4_HUMAN (540-1114): 4.05e-150: 476: 26.12		CEAM8_HUMAN (1-333): 1.23e-75: 238: 57.06
+	Hs
		710247 EPHA2_HUMAN (391-1137): 2.58e-164: 513: 21.15		OPCM_HUMAN (13-317): 6.49e-59: 194: 18.27
+	Hs
		710503 EPHA2_HUMAN (391-1137): 2.58e-164: 513: 21.15		ROBO2_HUMAN (3-335): 1.04e-54: 194: 13.28
+	Hs
		541492 FGFR1_HUMAN (333-1135): 6.1e-158: 492: 23.34		OPCM_HUMAN (13-317): 6.49e-59: 194: 18.27
+	Hs
		710633 EPHA3_HUMAN (452-1135): 1.16e-167: 523: 21.73		CEA21_HUMAN (153-321): 3.11e-17: 82.5: 16.08
+	Hs
		932081 EPHA4_HUMAN (391-1137): 5.92e-166: 518: 19.90		CEA21_HUMAN (153-321): 3.11e-17: 82.5: 16.08
+	Hs
		71378 FGFR1_HUMAN (333-1135): 6.1e-158: 492: 23.34		HECA2_HUMAN (186-323): 9.51e-20: 91.3: 21.05
+	Hs
		710600 EPHA2_HUMAN (391-1137): 2.58e-164: 513: 21.15		ROBO1_HUMAN (210-318): 1.11e-11: 68: 19.53
+	Hs
		541521 FGFR1_HUMAN (333-1135): 6.1e-158: 492: 23.34		CEA21_HUMAN (153-321): 3.11e-17: 82.5: 16.08
+	Hs
		541438 FGFR1_HUMAN (333-1135): 6.1e-158: 492: 23.34		PGBM_HUMAN (151-323): 6.91e-15: 77.9: 18.92
+	Hs
		1101731 PTK7_HUMAN (337-1109): 4.51e-151: 481: 20.89		CEA21_HUMAN (153-321): 3.11e-17: 82.5: 16.08
+	Hs
		650128 FGFR3_HUMAN (354-1133): 3.78e-155: 484: 24.51		PGBM_HUMAN (151-323): 6.91e-15: 77.9: 18.92
+	Dm
		233626 ABL_DROME (828-1112): 5.61e-55: 212: 41.58		O44924_DROME (27-332): 6.94e-51: 183: 14.68
+	Hs
		648757 FGFR4_HUMAN (845-1133): 1.75e-65: 239: 46.15		ROBO1_HUMAN (210-318): 1.11e-11: 68: 19.53
+	Hs
		609985 VGFR1_HUMAN (825-1113): 2.34e-57: 219: 37.50		PGBM_HUMAN (151-323): 6.91e-15: 77.9: 18.92