HitPredict

Interactor 1: K1C20 (P35900)
Keratin, type I cytoskeletal 20 (Cytokeratin-20) (CK-20) (Keratin-20) (K20) (Protein IT)
Gene: KRT20

Interactor 2: K2C6C (P48668)
Keratin, type II cytoskeletal 6C (Cytokeratin-6C) (CK-6C) (Cytokeratin-6E) (CK-6E) (Keratin K6h) (Keratin-6C) (K6C) (Type-II keratin Kb12)
Gene: KRT6C

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35575683
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Filament~Filament
Common GO terms	GO:0005829 - cytosol GO:0005882 - intermediate filament GO:0045109 - intermediate filament organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 424 Hs			1 564
+	Hs
		437109 K1C20_HUMAN (1-424): 8.19e-156: 448: 100.00		K2C8_HUMAN (135-511): 4.8e-165: 479: 68.70
+	Hs
		475745 K1C20_HUMAN (1-424): 8.19e-156: 448: 100.00		K2C7_HUMAN (103-534): 3.56e-157: 459: 63.30
+	Hs
		407357 K1C18_HUMAN (1-415): 1.84e-141: 412: 44.03		K2C1_HUMAN (128-494): 2.59e-165: 486: 73.57
+	Hs
		436763 K1C18_HUMAN (1-415): 1.84e-141: 412: 44.03		K2C8_HUMAN (135-511): 4.8e-165: 479: 68.70
+	Hs
		436770 K1C18_HUMAN (1-415): 1.84e-141: 412: 44.03		K2C7_HUMAN (103-534): 3.56e-157: 459: 63.30
+	Hs
		777412 K1C20_HUMAN (1-424): 8.19e-156: 448: 100.00		KRT84_HUMAN (1-555): 1.73e-104: 328: 48.58
+	Hs
		341740 K1C20_HUMAN (1-424): 8.19e-156: 448: 100.00		K2C75_HUMAN (3-564): 3.3e-101: 318: 68.50
+	Hs
		407255 K1C20_HUMAN (1-424): 8.19e-156: 448: 100.00		K2C6B_HUMAN (1-499): 1.28e-92: 296: 99.00
+	Hs
		385241 K1C20_HUMAN (1-424): 8.19e-156: 448: 100.00		K2C6A_HUMAN (1-499): 7.36e-88: 284: 98.40
+	Hs
		341723 K1C18_HUMAN (1-415): 1.84e-141: 412: 44.03		K2C75_HUMAN (3-564): 3.3e-101: 318: 68.50
+	Hs
		566336 K1C20_HUMAN (1-424): 8.19e-156: 448: 100.00		K2C5_HUMAN (3-479): 2.32e-86: 280: 77.43
+	Hs
		777397 K1C20_HUMAN (1-424): 8.19e-156: 448: 100.00		K2C79_HUMAN (29-555): 6.1e-84: 272: 61.51
+	Hs
		407236 K1C18_HUMAN (1-415): 1.84e-141: 412: 44.03		K2C6B_HUMAN (1-499): 1.28e-92: 296: 99.00
+	Hs
		777391 K1C20_HUMAN (1-424): 8.19e-156: 448: 100.00		K2C72_HUMAN (3-479): 3.41e-79: 259: 59.96
+	Hs
		385215 K1C18_HUMAN (1-415): 1.84e-141: 412: 44.03		K2C6A_HUMAN (1-499): 7.36e-88: 284: 98.40
+	Hs
		436782 K1C18_HUMAN (1-415): 1.84e-141: 412: 44.03		K2C5_HUMAN (3-479): 2.32e-86: 280: 77.43
+	Hs
		777388 K1C20_HUMAN (1-424): 8.19e-156: 448: 100.00		K22O_HUMAN (4-491): 5.87e-71: 241: 62.23
+	Hs
		551539 K1C20_HUMAN (1-424): 8.19e-156: 448: 100.00		K2C3_HUMAN (135-480): 7.98e-66: 227: 79.60
+	Mm
		1424269 K1C17_MOUSE (27-418): 1.14e-143: 418: 50.25		K2C7_MOUSE (83-492): 6.92e-67: 225: 63.17
+	Hs
		436777 K1C18_HUMAN (1-415): 1.84e-141: 412: 44.03		K2C3_HUMAN (135-480): 7.98e-66: 227: 79.60