HitPredict

Interactor 1: PK3CA (P42337)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PI3-kinase subunit alpha) (PI3K-alpha) (PI3Kalpha) (PtdIns-3-kinase subunit alpha) (EC 2.7.1.137) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha) (PtdIns-3-kinase subunit p110-alpha) (p110alpha) (Phosphoinositide-3-kinase catalytic alpha polypeptide) (Serine/threonine protein kinase PIK3CA) (EC 2.7.11.1)
Gene: Pik3ca

Interactor 2: RRAS2 (P62071)
Ras-related protein R-Ras2 (EC 3.6.5.-)
Gene: RRAS2

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	23706742
Identification Methods	pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PI3_PI4_kinase~Ras, PI3K_rbd~Ras
Common GO terms	GO:0005886 - plasma membrane GO:0016477 - cell migration
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1068 Mm			1 204
+	Mm
		500513 PK3CA_MOUSE (1-1068): 0: 1314: 100.00		RRAS_MOUSE (27-204): 1.89e-82: 245: 66.85
+	Hs
		787242 PK3CA_HUMAN (1-1068): 0: 1315: 98.69		RB11B_HUMAN (4-202): 3.83e-78: 234: 25.93
+	Mm
		140117 PK3CA_MOUSE (1-1068): 0: 1314: 100.00		RASM_MOUSE (27-177): 1.85e-63: 197: 63.16
+	Hs
		349170 PK3CA_HUMAN (1-1068): 0: 1315: 98.69		RASH_HUMAN (14-203): 8.87e-57: 179: 55.26
+	Mm
		787349 PK3CA_MOUSE (1-1068): 0: 1314: 100.00		RASH_MOUSE (14-203): 8.87e-57: 179: 55.26
+	Hs
		349946 PK3CA_HUMAN (1-1068): 0: 1315: 98.69		RASK_HUMAN (14-199): 3.15e-54: 172: 54.84
+	Mm
		699616 PK3CA_MOUSE (1-1068): 0: 1314: 100.00		RASK_MOUSE (14-203): 1.77e-54: 173: 54.12
+	Mm
		440301 PK3CA_MOUSE (1-1068): 0: 1314: 100.00		RASN_MOUSE (14-191): 5.48e-54: 172: 55.06
+	Mm
		193570 PK3CD_MOUSE (1-1065): 0: 1163: 39.72		RRAS2_MOUSE (1-204): 2.76e-84: 249: 100.00
+	Mm
		193565 PK3CD_MOUSE (1-1065): 0: 1163: 39.72		RRAS_MOUSE (27-204): 1.89e-82: 245: 66.85
+	Hs
		126186 PK3CD_HUMAN (1-1065): 0: 1167: 39.72		RASH_HUMAN (14-203): 8.87e-57: 179: 55.26
+	Mm
		193571 PK3CD_MOUSE (1-1065): 0: 1163: 39.72		RASH_MOUSE (14-203): 8.87e-57: 179: 55.26
+	Mm
		193569 PK3CD_MOUSE (1-1065): 0: 1163: 39.72		RASK_MOUSE (14-203): 1.77e-54: 173: 54.12
+	Mm
		193564 PK3CD_MOUSE (1-1065): 0: 1163: 39.72		RASN_MOUSE (14-191): 5.48e-54: 172: 55.06
+	Mm
		1142560 PK3CB_MOUSE (1-1065): 0: 1070: 38.57		RASH_MOUSE (14-203): 8.87e-57: 179: 55.26
+	Hs
		349947 PK3CB_HUMAN (1-1065): 0: 1050: 39.40		RASK_HUMAN (14-199): 3.15e-54: 172: 54.84
+	Dm
		381632 P91634_DROME (7-1065): 0: 954: 34.49		RAS2_DROME (13-199): 4.62e-82: 243: 71.12
+	Mm
		500516 PK3CG_MOUSE (1-1062): 0: 923: 32.29		RRAS_MOUSE (27-204): 1.89e-82: 245: 66.85
+	Dm
		442990 P91634_DROME (7-1065): 0: 954: 34.49		RAS1_DROME (14-182): 4.75e-56: 177: 60.95
+	Mm
		440303 PK3CG_MOUSE (1-1062): 0: 923: 32.29		RASN_MOUSE (14-191): 5.48e-54: 172: 55.06