HitPredict

Interactor 1: TGFR2 (P37173)
TGF-beta receptor type-2 (TGFR-2) (EC 2.7.11.30) (TGF-beta type II receptor) (Transforming growth factor-beta receptor type II) (TGF-beta receptor type II) (TbetaR-II)
Gene: TGFBR2

Interactor 2: SMUF1 (Q9HCE7)
E3 ubiquitin-protein ligase SMURF1 (hSMURF1) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF1) (SMAD ubiquitination regulatory factor 1) (SMAD-specific E3 ubiquitin-protein ligase 1)
Gene: SMURF1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	27048878, 11278251
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0046332 - SMAD binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 567 Hs			1 757
+	Mm
		1224009 TGFR2_MOUSE (1-567): 3.27e-148: 440: 92.24		SMUF1_MOUSE (1-757): 0: 840: 95.24
+	Hs
		1118390 BMPR2_HUMAN (25-567): 2.13e-116: 371: 28.34		SMUF1_HUMAN (1-757): 0: 877: 100.00
+	Hs
		1048391 ACVR1_HUMAN (53-549): 4.51e-120: 365: 28.46		SMUF1_HUMAN (1-757): 0: 877: 100.00
+	Hs
		787346 ACV1B_HUMAN (51-548): 1.24e-118: 362: 28.18		SMUF1_HUMAN (1-757): 0: 877: 100.00
+	Hs
		787451 TGFR1_HUMAN (48-548): 8.2e-117: 357: 29.62		SMUF1_HUMAN (1-757): 0: 877: 100.00
+	Hs
		128543 BMR1B_HUMAN (55-548): 6.17e-114: 349: 27.82		SMUF1_HUMAN (1-757): 0: 877: 100.00
+	Hs
		787251 BMR1A_HUMAN (61-548): 1.82e-113: 349: 26.68		SMUF1_HUMAN (1-757): 0: 877: 100.00
+	Hs
		789019 TGFR2_HUMAN (1-567): 4.65e-149: 442: 100.00		SMUF2_HUMAN (1-757): 0: 782: 71.43
+	Hs
		788992 TGFR2_HUMAN (1-567): 4.65e-149: 442: 100.00		ITCH_HUMAN (1-757): 0: 712: 30.88
+	Mm
		59030 TGFR1_MOUSE (43-548): 1.17e-120: 367: 29.13		SMUF2_MOUSE (1-757): 0: 785: 71.30
+	Hs
		787450 TGFR1_HUMAN (48-548): 8.2e-117: 357: 29.62		SMUF2_HUMAN (1-757): 0: 782: 71.43
+	Hs
		131776 TGFR2_HUMAN (1-567): 4.65e-149: 442: 100.00		WWP2_HUMAN (97-757): 0: 694: 36.69
+	Hs
		787441 TGFR1_HUMAN (48-548): 8.2e-117: 357: 29.62		ITCH_HUMAN (1-757): 0: 712: 30.88
+	Hs
		131772 BMR1A_HUMAN (61-548): 1.82e-113: 349: 26.68		WWP2_HUMAN (97-757): 0: 694: 36.69
+	Hs
		787334 ACV1B_HUMAN (51-548): 1.24e-118: 362: 28.18		NED4L_HUMAN (6-376): 3.89e-35: 145: 14.25
+	Hs
		787237 BMR1A_HUMAN (61-548): 1.82e-113: 349: 26.68		NED4L_HUMAN (6-376): 3.89e-35: 145: 14.25
+	Dm
		1377996 Q95SI0_DROME (56-542): 1.94e-120: 366: 31.35		SMUF1_DROME (5-373): 3.45e-29: 126: 29.65
+	Hs
		787360 TGFR1_HUMAN (48-548): 8.2e-117: 357: 29.62		NEDD4_HUMAN (72-379): 4.59e-10: 65.5: 9.39
+	Hs
		787121 BMR1A_HUMAN (61-548): 1.82e-113: 349: 26.68		NEDD4_HUMAN (72-379): 4.59e-10: 65.5: 9.39