HitPredict

Interactor 1: RANG (P43487)
Ran-specific GTPase-activating protein (Ran-binding protein 1) (RanBP1)
Gene: RANBP1

Interactor 2: RAN (P62826)
GTP-binding nuclear protein Ran (EC 3.6.5.-) (Androgen receptor-associated protein 24) (GTPase Ran) (Ras-like protein TC4) (Ras-related nuclear protein)
Gene: RAN

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.96	1.00	0.980

Property	Details
Experiments	10811801, 10779340, 35271311, 9111043, 7891706, 33961781, 34349018, 35235311, 20805321, 12649209, 7603572, 9315840, 11832950
Identification Methods	pull down, affinity chromatography technology, two hybrid, cross-linking study, x-ray crystallography, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Ran_BP1~Ras
Common GO terms	GO:0005634 - nucleus GO:0005635 - nuclear envelope GO:0005643 - nuclear pore GO:0005737 - cytoplasm GO:0005829 - cytosol and 1 others more... GO:0045296 - cadherin binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 201 Hs			1 216
+	At
		784994 RBP1A_ARATH (1-189): 6.56e-46: 153: 41.05		RAN1_ARATH (1-216): 1.39e-95: 279: 73.52
+	At
		784989 RBP1B_ARATH (3-201): 6.44e-42: 142: 38.50		RAN1_ARATH (1-216): 1.39e-95: 279: 73.52
+	At
		785000 RBP1A_ARATH (1-189): 6.56e-46: 153: 41.05		RAN2_ARATH (1-215): 1.36e-88: 261: 74.77
+	Ce
		184992 Q21021_CAEEL (3-162): 3.51e-34: 129: 31.90		RAN_CAEEL (3-205): 3.44e-97: 283: 88.18
+	Ce
		184995 Q86G90_CAEEL (3-162): 4.01e-34: 129: 31.90		RAN_CAEEL (3-205): 3.44e-97: 283: 88.18
+	Xl
		193796 O42193_XENLA (1-199): 2.19e-52: 168: 80.40		RAN_XENLA (1-216): 7.81e-80: 239: 98.15
+	Hs
		483392 RGPD1_HUMAN (1-201): 7.66e-48: 169: 34.80		RAN_HUMAN (1-216): 7.75e-79: 237: 100.00
+	Hs
		919141 RGPD4_HUMAN (1-201): 1.46e-47: 168: 34.80		RAN_HUMAN (1-216): 7.75e-79: 237: 100.00
+	Hs
		152774 RGPD8_HUMAN (1-201): 9.54e-47: 166: 34.31		RAN_HUMAN (1-216): 7.75e-79: 237: 100.00
+	Hs
		483422 RGPD2_HUMAN (1-201): 6.87e-47: 166: 34.31		RAN_HUMAN (1-216): 7.75e-79: 237: 100.00
+	At
		784991 NU50A_ARATH (32-183): 4.54e-33: 124: 20.00		RAN1_ARATH (1-216): 1.39e-95: 279: 73.52
+	At
		784998 RBP1B_ARATH (3-201): 6.44e-42: 142: 38.50		RAN2_ARATH (1-215): 1.36e-88: 261: 74.77
+	Hs
		919236 RGPD5_HUMAN (1-201): 9.73e-47: 166: 34.31		RAN_HUMAN (1-216): 7.75e-79: 237: 100.00
+	At
		1210455 RBP1A_ARATH (1-189): 6.56e-46: 153: 41.05		RAN3_ARATH (1-215): 9.1e-84: 249: 74.31
+	Hs
		63882 RGPD3_HUMAN (1-201): 2.17e-46: 165: 34.80		RAN_HUMAN (1-216): 7.75e-79: 237: 100.00
+	Hs
		834710 RBP2_HUMAN (4-164): 1.49e-44: 160: 47.83		RAN_HUMAN (1-216): 7.75e-79: 237: 100.00
+	At
		1210453 RBP1B_ARATH (3-201): 6.44e-42: 142: 38.50		RAN3_ARATH (1-215): 9.1e-84: 249: 74.31
+	Sc
		698847 YRB1_YEAST (3-165): 2.48e-40: 137: 50.31		GSP1_YEAST (1-214): 5.23e-83: 247: 80.56
+	Sp
		660086 RANG_SCHPO (2-168): 1.63e-37: 131: 50.90		SPI1_SCHPO (1-214): 1.23e-84: 251: 80.84
+	Hs
		919269 RANB3_HUMAN (10-186): 4.16e-30: 117: 16.75		RAN_HUMAN (1-216): 7.75e-79: 237: 100.00