HitPredict

Interactor 1: STAT3 (P42227)
Signal transducer and activator of transcription 3 (Acute-phase response factor)
Gene: STAT3

Interactor 2: TIE2 (Q02858)
Angiopoietin-1 receptor (EC 2.7.10.1) (Endothelial tyrosine kinase) (HYK) (STK1) (Tunica interna endothelial cell kinase) (Tyrosine kinase with Ig and EGF homology domains-2) (Tyrosine-protein kinase receptor TEK) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (p140 TEK) (CD antigen CD202b)
Gene: Tek

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	18065416
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~fn3, PK_Tyr_Ser-Thr~SH2, STAT_alpha~fn3
Common GO terms	GO:0005886 - plasma membrane GO:0045766 - positive regulation of angiogenesis
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 770 Mm			1 1122
+	Hs
		827721 STAT3_HUMAN (1-770): 0: 1047: 99.87		EPHA5_HUMAN (240-1122): 0: 652: 17.82
+	Hs
		541379 STAT3_HUMAN (1-770): 0: 1047: 99.87		FGFR1_HUMAN (335-1122): 1.22e-167: 517: 23.17
+	Hs
		650073 STAT3_HUMAN (1-770): 0: 1047: 99.87		FGFR3_HUMAN (470-1116): 9.69e-168: 516: 25.57
+	Hs
		439673 STAT3_HUMAN (1-770): 0: 1047: 99.87		INSR_HUMAN (401-1112): 1.87e-156: 503: 21.07
+	Hs
		641133 STAT3_HUMAN (1-770): 0: 1047: 99.87		FGFR2_HUMAN (342-1122): 1.43e-161: 501: 22.14
+	Hs
		907260 STA5B_HUMAN (1-734): 0: 752: 30.55		EPHA4_HUMAN (265-1122): 0: 651: 18.78
+	Hs
		913123 STAT2_HUMAN (1-728): 0: 786: 38.47		EPHB4_HUMAN (293-1099): 3.17e-178: 550: 18.23
+	Hs
		463916 STAT3_HUMAN (1-770): 0: 1047: 99.87		RET_HUMAN (828-1102): 1.86e-67: 249: 45.02
+	Mm
		838273 STAT3_MOUSE (1-770): 0: 1050: 100.00		FER_MOUSE (774-1083): 5.17e-60: 223: 39.10
+	Hs
		827692 STAT3_HUMAN (1-770): 0: 1047: 99.87		ABL2_HUMAN (811-1096): 7.75e-56: 214: 39.19
+	Hs
		439687 STA5B_HUMAN (1-734): 0: 752: 30.55		INSR_HUMAN (401-1112): 1.87e-156: 503: 21.07
+	Hs
		641140 STA5B_HUMAN (1-734): 0: 752: 30.55		FGFR2_HUMAN (342-1122): 1.43e-161: 501: 22.14
+	Hs
		439675 STA5A_HUMAN (1-734): 0: 745: 30.42		INSR_HUMAN (401-1112): 1.87e-156: 503: 21.07
+	Hs
		641136 STA5A_HUMAN (1-734): 0: 745: 30.42		FGFR2_HUMAN (342-1122): 1.43e-161: 501: 22.14
+	Hs
		362195 STAT1_HUMAN (1-749): 0: 929: 51.52		ABL1_HUMAN (801-1096): 7.64e-56: 213: 37.91
+	Hs
		362218 STA5B_HUMAN (1-734): 0: 752: 30.55		ABL1_HUMAN (801-1096): 7.64e-56: 213: 37.91
+	Hs
		362196 STA5A_HUMAN (1-734): 0: 745: 30.42		ABL1_HUMAN (801-1096): 7.64e-56: 213: 37.91