HitPredict

Interactor 1: SMCA4 (P51532)
Transcription activator BRG1 (EC 3.6.4.-) (ATP-dependent helicase SMARCA4) (BRG1-associated factor 190A) (BAF190A) (Mitotic growth and transcription activator) (Protein BRG-1) (Protein brahma homolog 1) (SNF2-beta) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4)
Gene: SMARCA4

Interactor 2: IMA1 (P52292)
Importin subunit alpha-1 (Karyopherin subunit alpha-2) (RAG cohort protein 1) (SRP1-alpha)
Gene: KPNA2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	33961781, 35271311, 20460684
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1647 Hs			1 529
+	Hs
		131405 SMCA4_HUMAN (1-1647): 0: 1105: 100.00		IMA4_HUMAN (4-529): 6.93e-148: 436: 49.06
+	Hs
		846902 SMCA4_HUMAN (1-1647): 0: 1105: 100.00		IMA5_HUMAN (4-528): 7.39e-133: 398: 44.47
+	Hs
		853716 Q9HBD4_HUMAN (1-1647): 0: 1096: 97.38		IMA5_HUMAN (4-528): 7.39e-133: 398: 44.47
+	Hs
		846725 SMCA2_HUMAN (1-1647): 0: 980: 71.69		IMA1_HUMAN (1-529): 6.78e-164: 477: 100.00
+	Hs
		846726 SMCA2_HUMAN (1-1647): 0: 980: 71.69		IMA5_HUMAN (4-528): 7.39e-133: 398: 44.47
+	Hs
		229344 SMCA5_HUMAN (626-1631): 0: 835: 27.41		IMA5_HUMAN (4-528): 7.39e-133: 398: 44.47
+	Hs
		658643 SMCA1_HUMAN (639-1619): 0: 832: 28.82		IMA5_HUMAN (4-528): 7.39e-133: 398: 44.47
+	Hs
		853286 CHD4_HUMAN (482-1630): 0: 722: 23.79		IMA1_HUMAN (1-529): 6.78e-164: 477: 100.00
+	Mm
		853539 CHD8_MOUSE (18-1527): 0: 718: 20.36		IMA1_MOUSE (1-529): 2.1e-162: 473: 94.52
+	Hs
		134899 CHD4_HUMAN (482-1630): 0: 722: 23.79		IMA3_HUMAN (4-529): 5.61e-152: 446: 50.38
+	Sc
		744898 ISW1_YEAST (550-1646): 0: 745: 25.77		IMA1_YEAST (2-529): 3.96e-141: 419: 43.83
+	Hs
		134969 CHD8_HUMAN (13-1523): 0: 711: 21.11		IMA3_HUMAN (4-529): 5.61e-152: 446: 50.38
+	Mm
		192636 CHD8_MOUSE (18-1527): 0: 718: 20.36		IMA4_MOUSE (4-529): 8.91e-149: 438: 49.06
+	Hs
		238679 CHD4_HUMAN (482-1630): 0: 722: 23.79		IMA7_HUMAN (1-528): 1.97e-141: 420: 45.37
+	Dm
		853771 ISWI_DROME (692-1647): 0: 771: 28.17		IMA_DROME (6-529): 2.4e-121: 368: 48.30
+	Hs
		168636 CHD4_HUMAN (482-1630): 0: 722: 23.79		IMA6_HUMAN (1-528): 9.99e-138: 410: 45.02
+	Hs
		238743 CHD8_HUMAN (13-1523): 0: 711: 21.11		IMA7_HUMAN (1-528): 1.97e-141: 420: 45.37
+	Hs
		168673 CHD8_HUMAN (13-1523): 0: 711: 21.11		IMA6_HUMAN (1-528): 9.99e-138: 410: 45.02
+	Hs
		853602 CHD4_HUMAN (482-1630): 0: 722: 23.79		IMA5_HUMAN (4-528): 7.39e-133: 398: 44.47
+	Mm
		1000155 CHD8_MOUSE (18-1527): 0: 718: 20.36		IMA5_MOUSE (4-528): 2.02e-131: 394: 44.65