HitPredict

Interactor 1: GBG5 (P63218)
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
Gene: GNG5

Interactor 2: GBB4 (Q9HAV0)
Guanine nucleotide-binding protein subunit beta-4 (Transducin beta chain 4)
Gene: GNB4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.60	0.690

Property	Details
Experiments	33961781, 8636150, 40437099, 12782285
Identification Methods	affinity chromatography technology, two hybrid, cross-linking study, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005834 - heterotrimeric G-protein complex GO:0007186 - G protein-coupled receptor signaling pathway GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 68 Hs			1 340
+	Hs
		243467 GBG7_HUMAN (1-68): 1.09e-27: 96.2: 51.47		GBB2_HUMAN (1-340): 8.23e-110: 325: 90.00
+	Hs
		243474 GBG7_HUMAN (1-68): 1.09e-27: 96.2: 51.47		GBB4_HUMAN (1-340): 1.1e-109: 324: 100.00
+	Hs
		984316 GBG12_HUMAN (2-68): 5.43e-26: 92: 46.27		GBB2_HUMAN (1-340): 8.23e-110: 325: 90.00
+	Hs
		948052 GBG2_HUMAN (2-68): 6.58e-26: 91.6: 48.53		GBB2_HUMAN (1-340): 8.23e-110: 325: 90.00
+	Hs
		1437752 GBG12_HUMAN (2-68): 5.43e-26: 92: 46.27		GBB4_HUMAN (1-340): 1.1e-109: 324: 100.00
+	Hs
		984064 GBG3_HUMAN (1-68): 1.31e-25: 90.9: 46.38		GBB2_HUMAN (1-340): 8.23e-110: 325: 90.00
+	Hs
		948081 GBG2_HUMAN (2-68): 6.58e-26: 91.6: 48.53		GBB4_HUMAN (1-340): 1.1e-109: 324: 100.00
+	Hs
		243466 GBG7_HUMAN (1-68): 1.09e-27: 96.2: 51.47		GBB1_HUMAN (1-340): 6.08e-106: 315: 90.88
+	Hs
		243464 GBG7_HUMAN (1-68): 1.09e-27: 96.2: 51.47		GBB3_HUMAN (1-340): 3.74e-105: 313: 79.71
+	Hs
		983605 GBG12_HUMAN (2-68): 5.43e-26: 92: 46.27		GBB1_HUMAN (1-340): 6.08e-106: 315: 90.88
+	Hs
		948051 GBG2_HUMAN (2-68): 6.58e-26: 91.6: 48.53		GBB1_HUMAN (1-340): 6.08e-106: 315: 90.88
+	Bt
		983440 GBG2_BOVIN (2-68): 6.58e-26: 91.6: 48.53		GBB1_BOVIN (1-340): 6.08e-106: 315: 90.88
+	Mm
		983624 GBG2_MOUSE (2-68): 6.58e-26: 91.6: 48.53		GBB1_MOUSE (1-340): 6.08e-106: 315: 90.88
+	Hs
		983447 GBG3_HUMAN (1-68): 1.31e-25: 90.9: 46.38		GBB1_HUMAN (1-340): 6.08e-106: 315: 90.88
+	Hs
		597375 GBG12_HUMAN (2-68): 5.43e-26: 92: 46.27		GBB3_HUMAN (1-340): 3.74e-105: 313: 79.71
+	Hs
		597349 GBG2_HUMAN (2-68): 6.58e-26: 91.6: 48.53		GBB3_HUMAN (1-340): 3.74e-105: 313: 79.71
+	Hs
		597353 GBG3_HUMAN (1-68): 1.31e-25: 90.9: 46.38		GBB3_HUMAN (1-340): 3.74e-105: 313: 79.71
+	Hs
		163603 GBG7_HUMAN (1-68): 1.09e-27: 96.2: 51.47		GNB5_HUMAN (129-340): 3.22e-42: 152: 22.62
+	Hs
		163627 GBG2_HUMAN (2-68): 6.58e-26: 91.6: 48.53		GNB5_HUMAN (129-340): 3.22e-42: 152: 22.62
+	Hs
		163629 GBG3_HUMAN (1-68): 1.31e-25: 90.9: 46.38		GNB5_HUMAN (129-340): 3.22e-42: 152: 22.62