Protein: PESC
Pescadillo homolog

Gene: PESC, PES1
Organism: Homo sapiens
Interactions: 221
UniProt ID: O00541

Gene Ontology (top 5):
GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000466 - maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0003723 - RNA binding
GO:0005654 - nucleoplasm
GO:0005694 - chromosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

139603

WDR12
Ribosome biogenesis protein WDR12

11

4

Small-scale

0.977

High

139530

BOP1
Ribosome biogenesis protein BOP1

11

4

Small-scale

0.976

High

139552

RL7L
Ribosomal protein uL30-like

6

3

Small-scale

0.945

High

139428

PESC
Pescadillo homolog

2

1

Small-scale

0.754

High

139514

CSK21
Casein kinase II subunit alpha

5

4

High-throughput

0.720

High

139581

DDX27
Probable ATP-dependent RNA helicase DDX27

5

7

Small-scale

0.712

High

139458

MYC
Myc proto-oncogene protein

5

1

High-throughput

0.702

High

139571

NOC3L
Nucleolar complex protein 3 homolog

3

4

Small-scale

0.667

High

139478

CSK22
Casein kinase II subunit alpha'

3

4

High-throughput

0.662

High

139583

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

3

1

High-throughput

0.662

High

139496

MAGAA
Melanoma-associated antigen 10

4

0

High-throughput

0.661

High

139463

P53
Cellular tumor antigen p53

1

0

High-throughput

0.656

High

139544

IF16
Gamma-interferon-inducible protein 16

3

3

High-throughput

0.656

High

139449

BRD4
Bromodomain-containing protein 4

3

3

High-throughput

0.640

High

139438

TNC18
Trinucleotide repeat-containing gene 18 protein

3

0

High-throughput

0.634

High

139468

CENPB
Major centromere autoantigen B

3

0

High-throughput

0.634

High

126021

AP3B1
AP-3 complex subunit beta-1

2

1

High-throughput

0.628

High

139434

SET1A
Histone-lysine N-methyltransferase SETD1A

2

1

High-throughput

0.628

High

139437

NVL
Nuclear valosin-containing protein-like

2

3

High-throughput

0.628

High

139474

UBF1
Nucleolar transcription factor 1

2

1

High-throughput

0.628

High

139482

BRD2
Bromodomain-containing protein 2

2

4

High-throughput

0.628

High

139545

F263
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3

2

1

High-throughput

0.628

High

139573

KBTB7
Kelch repeat and BTB domain-containing protein 7

2

1

High-throughput

0.628

High

139610

WDR55
WD repeat-containing protein 55

2

2

High-throughput

0.628

High

139612

CWC22
Pre-mRNA-splicing factor CWC22 homolog

2

1

High-throughput

0.628

High

139444

BUB3
Mitotic checkpoint protein BUB3

1

1

Small-scale

0.618

High

139471

PARP1
Poly [ADP-ribose] polymerase 1

1

2

High-throughput

0.618

High

139578

FBXW7
F-box/WD repeat-containing protein 7

1

1

High-throughput

0.618

High

139618

DCA13
DDB1- and CUL4-associated factor 13

1

3

Small-scale

0.618

High

139467

NPM
Nucleophosmin

2

1

High-throughput

0.611

High

139433

CASQ2
Calsequestrin-2

3

2

High-throughput

0.609

High

139494

AF9
Protein AF-9

2

0

High-throughput

0.602

High

139522

TRI26
Tripartite motif-containing protein 26

2

0

High-throughput

0.602

High

139541

RNPS1
RNA-binding protein with serine-rich domain 1

2

0

High-throughput

0.602

High

139559

CCD91
Coiled-coil domain-containing protein 91

2

0

High-throughput

0.602

High

139594

INP5K
Inositol polyphosphate 5-phosphatase K

2

0

High-throughput

0.602

High

139608

PININ
Pinin

2

0

High-throughput

0.602

High

139624

CXXC1
CXXC-type zinc finger protein 1

2

0

High-throughput

0.602

High

139630

AFF4
AF4/FMR2 family member 4

2

0

High-throughput

0.602

High

139575

TOPB1
DNA topoisomerase 2-binding protein 1

1

0

High-throughput

0.586

High

139526

G3BP1
Ras GTPase-activating protein-binding protein 1

2

0

Small-scale

0.585

High

139445

PRKN
E3 ubiquitin-protein ligase parkin

2

1

High-throughput

0.584

High

139510

RS6
Small ribosomal subunit protein eS6

2

1

High-throughput

0.584

High

139515

H31
Histone H3.1

2

3

High-throughput

0.584

High

139542

EZH2
Histone-lysine N-methyltransferase EZH2

2

1

High-throughput

0.584

High

139568

SERB1
SERPINE1 mRNA-binding protein 1

2

1

High-throughput

0.584

High

139601

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

2

2

High-throughput

0.584

High

139436

WDR46
WD repeat-containing protein 46

1

4

High-throughput

0.575

High

139459

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

139534

RRP1B
Ribosomal RNA processing protein 1 homolog B

2

2

Small-scale

0.571

High

139576

ESR2
Estrogen receptor beta

2

1

High-throughput

0.571

High

139450

OBSL1
Obscurin-like protein 1

2

0

High-throughput

0.559

High

139492

CCNF
Cyclin-F

2

0

High-throughput

0.559

High

139615

ANLN
Anillin

2

0

High-throughput

0.559

High

139521

FOXM1
Forkhead box protein M1

1

1

High-throughput

0.554

High

139432

AIM2
Interferon-inducible protein AIM2

1

3

High-throughput

0.536

High

139453

NPM3
Nucleoplasmin-3

1

1

High-throughput

0.536

High

139493

MNDA
Myeloid cell nuclear differentiation antigen

1

3

High-throughput

0.536

High

139497

KI67
Proliferation marker protein Ki-67

1

1

High-throughput

0.536

High

139508

FOXL2
Forkhead box protein L2

1

1

High-throughput

0.536

High

139528

KRR1
KRR1 small subunit processome component homolog

1

1

High-throughput

0.536

High

139562

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

1

High-throughput

0.536

High

139597

UT14A
U3 small nucleolar RNA-associated protein 14 homolog A

1

2

High-throughput

0.536

High

139614

TF7L2
Transcription factor 7-like 2

1

1

High-throughput

0.536

High

139628

NXF1
Nuclear RNA export factor 1

1

1

High-throughput

0.536

High

139636

DRG1
Developmentally-regulated GTP-binding protein 1

1

3

High-throughput

0.536

High

139640

RL36
Large ribosomal subunit protein eL36

1

2

High-throughput

0.536

High

139487

ARRB2
Beta-arrestin-2

1

1

High-throughput

0.515

High

139502

ARRB1
Beta-arrestin-1

1

1

High-throughput

0.515

High

139634

BRPF3
Bromodomain and PHD finger-containing protein 3

1

2

High-throughput

0.515

High

139507

ATX1
Ataxin-1

1

1

High-throughput

0.515

High

139479

LMNB1
Lamin-B1

1

0

High-throughput

0.513

High

139517

SRPK2
SRSF protein kinase 2

1

0

High-throughput

0.513

High

139529

CUL3
Cullin-3

1

0

High-throughput

0.513

High

139564

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.513

High

139572

PPIL4
Peptidyl-prolyl cis-trans isomerase-like 4

1

0

High-throughput

0.513

High

139587

XPO6
Exportin-6

1

0

High-throughput

0.513

High

139635

SRRM2
Serine/arginine repetitive matrix protein 2

1

0

High-throughput

0.513

High

139577

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

1

High-throughput

0.501

High

139532

CAPR1
Caprin-1

1

0

High-throughput

0.493

High

139585

CEP19
Centrosomal protein of 19 kDa

1

0

High-throughput

0.493

High

139632

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

0

High-throughput

0.493

High

139495

HD
Huntingtin

1

0

High-throughput

0.493

High

139465

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

139429

NOP56
Nucleolar protein 56

1

2

High-throughput

0.479

High

139430

DDX3X
ATP-dependent RNA helicase DDX3X

1

2

Small-scale

0.479

High

139441

SNUT1
U4/U6.U5 tri-snRNP-associated protein 1

1

1

Small-scale

0.479

High

139447

CC14B
Dual specificity protein phosphatase CDC14B

1

1

High-throughput

0.479

High

139448

DKC1
H/ACA ribonucleoprotein complex subunit DKC1

1

1

Small-scale

0.479

High

139452

PR40A
Pre-mRNA-processing factor 40 homolog A

1

2

Small-scale

0.479

High

139455

DNJC8
DnaJ homolog subfamily C member 8

1

2

High-throughput

0.479

High

139457

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

2

High-throughput

0.479

High

139461

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.479

High

139470

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

2

High-throughput

0.479

High

139473

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

139475

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

139477

NUCL
Nucleolin

1

1

High-throughput

0.479

High

139481

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

1

High-throughput

0.479

High

139483

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

139485

PDIA3
Protein disulfide-isomerase A3

1

1

Small-scale

0.479

High

139486

STIP1
Stress-induced-phosphoprotein 1

1

1

High-throughput

0.479

High

139498

NOP2
28S rRNA

1

2

Small-scale

0.479

High

139499

SOX2
Transcription factor SOX-2

1

1

High-throughput

0.479

High

139501

CDK8
Cyclin-dependent kinase 8

1

1

High-throughput

0.479

High

139503

CENPA
Histone H3-like centromeric protein A

1

3

High-throughput

0.479

High

139512

RS24
Small ribosomal subunit protein eS24

1

1

High-throughput

0.479

High

139513

RL31
Large ribosomal subunit protein eL31

1

1

High-throughput

0.479

High

139518

RED1
Double-stranded RNA-specific editase 1

1

2

High-throughput

0.479

High

139519

H33
Histone H3.3

1

3

High-throughput

0.479

High

139523

ILF3
Interleukin enhancer-binding factor 3

1

2

High-throughput

0.479

High

139525

TIF1B
Transcription intermediary factor 1-beta

1

1

High-throughput

0.479

High

139535

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

1

High-throughput

0.479

High

139538

TNIP1
TNFAIP3-interacting protein 1

1

2

High-throughput

0.479

High

139539

RRS1
Ribosome biogenesis regulatory protein homolog

1

1

Small-scale

0.479

High

139540

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.479

High

139546

LARP7
La-related protein 7

1

5

High-throughput

0.479

High

139548

RRP12
RRP12-like protein

1

2

Small-scale

0.479

High

139549

HABP4
Intracellular hyaluronan-binding protein 4

1

1

High-throughput

0.479

High

139551

RC3H1
Roquin-1

1

1

High-throughput

0.479

High

139553

IFIX
Pyrin and HIN domain-containing protein 1

1

3

High-throughput

0.479

High

139557

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

2

Small-scale

0.479

High

139563

SLX4
Structure-specific endonuclease subunit SLX4

1

1

High-throughput

0.479

High

139569

BRX1
Ribosome biogenesis protein BRX1 homolog

1

6

Small-scale

0.479

High

139574

DNJC9
DnaJ homolog subfamily C member 9

1

2

High-throughput

0.479

High

139589

RING2
E3 ubiquitin-protein ligase RING2

1

1

High-throughput

0.479

High

139591

EBP2
Probable rRNA-processing protein EBP2

1

1

Small-scale

0.479

High

139592

MBB1A
Myb-binding protein 1A

1

1

Small-scale

0.479

High

139593

RIOK1
Serine/threonine-protein kinase RIO1

1

1

High-throughput

0.479

High

139596

DDX23
Probable ATP-dependent RNA helicase DDX23

1

3

High-throughput

0.479

High

139599

FACD2
Fanconi anemia group D2 protein

1

1

High-throughput

0.479

High

139602

GTPB4
GTP-binding protein 4

1

4

Small-scale

0.479

High

139611

RC3H2
Roquin-2

1

1

High-throughput

0.479

High

139613

BRD7
Bromodomain-containing protein 7

1

2

High-throughput

0.479

High

139619

DDX18
ATP-dependent RNA helicase DDX18

1

8

Small-scale

0.479

High

139622

AATF
Protein AATF

1

2

High-throughput

0.479

High

139623

NOP53
Ribosome biogenesis protein NOP53

1

1

High-throughput

0.479

High

139627

RRBP1
Ribosome-binding protein 1

1

3

Small-scale

0.479

High

139633

MRT4
mRNA turnover protein 4 homolog

1

2

Small-scale

0.479

High

139639

NOC2L
Nucleolar complex protein 2 homolog

1

1

Small-scale

0.479

High

122666

KIF2A
Kinesin-like protein KIF2A

1

0

Small-scale

0.458

High

128605

MEN1
Menin

1

0

High-throughput

0.458

High

131567

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

0

High-throughput

0.458

High

134473

SAP18
Histone deacetylase complex subunit SAP18

1

0

High-throughput

0.458

High

139431

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.458

High

139435

BET1
BET1 homolog

1

0

High-throughput

0.458

High

139439

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

0

High-throughput

0.458

High

139440

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.458

High

139442

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

139443

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.458

High

139446

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

139451

DNJB6
DnaJ homolog subfamily B member 6

1

0

High-throughput

0.458

High

139456

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

139460

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

139469

LYN
Tyrosine-protein kinase Lyn

1

0

High-throughput

0.458

High

139472

TOP1
DNA topoisomerase 1

1

0

Small-scale

0.458

High

139484

APEX1
DNA repair nuclease/redox regulator APEX1

1

0

High-throughput

0.458

High

139488

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

139489

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

139490

MYH9
Myosin-9

1

0

Small-scale

0.458

High

139500

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

139505

CDK7
Cyclin-dependent kinase 7

1

0

High-throughput

0.458

High

139506

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.458

High

139509

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

139511

H4
Histone H4

1

0

High-throughput

0.458

High

139516

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.458

High

139520

KIF23
Kinesin-like protein KIF23

1

0

High-throughput

0.458

High

139524

NFX1
Transcriptional repressor NF-X1

1

0

High-throughput

0.458

High

139527

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

139531

ELOA1
Elongin-A

1

0

Small-scale

0.458

High

139533

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.458

High

139536

CUL7
Cullin-7

1

0

High-throughput

0.458

High

139537

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.458

High

139543

FSCN1
Fascin

1

0

High-throughput

0.458

High

139547

MIDN
Midnolin

1

0

High-throughput

0.458

High

139560

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

139561

ZCH18
Zinc finger CCCH domain-containing protein 18

1

0

High-throughput

0.458

High

139566

CGAS
Cyclic GMP-AMP synthase

1

0

High-throughput

0.458

High

139570

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

139582

PRR11
Proline-rich protein 11

1

0

High-throughput

0.458

High

139584

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

139586

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

139588

RANB9
Ran-binding protein 9

1

0

High-throughput

0.458

High

139590

POP1
Ribonucleases P/MRP protein subunit POP1

1

0

Small-scale

0.458

High

139595

MMTA2
Multiple myeloma tumor-associated protein 2

1

0

Small-scale

0.458

High

139600

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

139604

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

0

High-throughput

0.458

High

139607

ATG5
Autophagy protein 5

1

0

High-throughput

0.458

High

139617

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

0

High-throughput

0.458

High

139620

AKIP
Small ribosomal subunit protein mS38

1

0

High-throughput

0.458

High

139625

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

0

High-throughput

0.458

High

139626

COPZ2
Coatomer subunit zeta-2

1

0

High-throughput

0.458

High

139629

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

139631

MKRN1
E3 ubiquitin-protein ligase makorin-1

1

0

High-throughput

0.458

High

139638

ZN330
Zinc finger protein 330

1

0

High-throughput

0.458

High

139466

JUN
Transcription factor Jun

1

1

High-throughput

0.445

High

139555

RN111
E3 ubiquitin-protein ligase Arkadia

1

1

High-throughput

0.445

High

139464

H2A1B
Histone H2A type 1-B/E

1

1

High-throughput

0.437

High

139556

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

139558

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.437

High

139609

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

139641

MAFB
Transcription factor MafB

1

1

High-throughput

0.437

High

62413

S35F4
Solute carrier family 35 member F4

1

0

High-throughput

0.426

High

139550

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

139605

MAGT1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1

1

0

High-throughput

0.426

High

139621

LYAR
Cell growth-regulating nucleolar protein

1

0

High-throughput

0.426

High

139504

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.408

High

139579

ARK2N
Protein ARK2N

3

0

High-throughput

0.345

High

139567

KLH23
Kelch-like protein 23

2

0

High-throughput

0.328

High

139606

MYLK2
Myosin light chain kinase 2, skeletal/cardiac muscle

2

0

High-throughput

0.298

High

139580

HDA11
Histone deacetylase 11

1

0

High-throughput

0.279

Low

139637

MAST1
Microtubule-associated serine/threonine-protein kinase 1

1

0

High-throughput

0.279

Low

139598

KLF16
Krueppel-like factor 16

1

0

High-throughput

0.261

Low

139454

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

139462

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

139480

EPHA1
Ephrin type-A receptor 1

1

0

High-throughput

0.249

Low

139491

TRI23
E3 ubiquitin-protein ligase TRIM23

1

0

Small-scale

0.249

Low

139554

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

139565

FBXL6
F-box/LRR-repeat protein 6

1

0

High-throughput

0.249

Low

139616

TLR9
Toll-like receptor 9

1

0

Small-scale

0.249

Low

139476

VCAM1
Vascular cell adhesion protein 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025