Protein: CD226
CD226 antigen (DNAX accessory molecule 1) (DNAM-1) (CD antigen CD226)

Gene: CD226
Organism: Homo sapiens
Interactions: 114
UniProt ID: Q15762

Gene Ontology (top 5):
GO:0002729 - positive regulation of natural killer cell cytokine production
GO:0002860 - positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
GO:0002891 - positive regulation of immunoglobulin mediated immune response
GO:0005178 - integrin binding
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

580773

PVR
Poliovirus receptor

4

17

Small-scale

0.886

High

1153387

CD226
CD226 antigen

2

19

Small-scale

0.768

High

1153418

NECT2
Nectin-2

2

18

Small-scale

0.768

High

839459

PI4KA
Phosphatidylinositol 4-kinase alpha

2

7

High-throughput

0.712

High

1153435

TMX4
Thioredoxin-related transmembrane protein 4

2

12

High-throughput

0.694

High

501823

CO4A
Complement C4-A

1

3

High-throughput

0.691

High

834660

TNFL9
Tumor necrosis factor ligand superfamily member 9

1

1

High-throughput

0.691

High

931242

AT12A
Potassium-transporting ATPase alpha chain 2

1

6

High-throughput

0.691

High

1153389

AT2B3
Plasma membrane calcium-transporting ATPase 3

1

9

High-throughput

0.691

High

1153407

TTC7B
Tetratricopeptide repeat protein 7B

1

3

High-throughput

0.691

High

1153448

GPC5B
G-protein coupled receptor family C group 5 member B

1

2

High-throughput

0.691

High

1153390

TIGIT
T-cell immunoreceptor with Ig and ITIM domains

1

5

Small-scale

0.665

High

630812

RAB4A
Ras-related protein Rab-4A

1

20

High-throughput

0.618

High

1109452

ATR
Serine/threonine-protein kinase ATR

1

13

High-throughput

0.618

High

1153400

DUSTY
Dual serine/threonine and tyrosine protein kinase

1

10

High-throughput

0.618

High

1153414

KLH23
Kelch-like protein 23

1

1

High-throughput

0.618

High

1153459

KDIS
Kinase D-interacting substrate of 220 kDa

1

6

High-throughput

0.618

High

424084

ITB2
Integrin beta-2

1

8

Small-scale

0.618

High

637903

NF1
Neurofibromin

2

10

High-throughput

0.601

High

1105845

TMED1
Transmembrane emp24 domain-containing protein 1

2

4

High-throughput

0.601

High

1124184

EI2BA
Translation initiation factor eIF2B subunit alpha

2

6

High-throughput

0.601

High

1153394

MBLC2
Acyl-coenzyme A thioesterase MBLAC2

2

1

High-throughput

0.601

High

1153431

TTYH3
Protein tweety homolog 3

2

1

High-throughput

0.601

High

127337

LEG8
Galectin-8

1

18

High-throughput

0.575

High

229872

EDIL3
EGF-like repeat and discoidin I-like domain-containing protein 3

1

7

High-throughput

0.575

High

297353

DYSF
Dysferlin

1

7

High-throughput

0.575

High

1153401

CD109
CD109 antigen

1

3

High-throughput

0.575

High

1153415

RAI3
Retinoic acid-induced protein 3

1

2

High-throughput

0.575

High

1153451

FPRP
Prostaglandin F2 receptor negative regulator

1

10

High-throughput

0.575

High

1153391

Q4LE69
Phosphatidylinositol 4-kinase alpha

1

2

High-throughput

0.553

High

890119

EI2BB
Translation initiation factor eIF2B subunit beta

2

6

High-throughput

0.549

High

1095882

EI2BE
Translation initiation factor eIF2B subunit epsilon

2

4

High-throughput

0.549

High

1153413

ARL10
ADP-ribosylation factor-like protein 10

2

20

High-throughput

0.549

High

1153439

ZDHC6
Palmitoyltransferase ZDHHC6

2

4

High-throughput

0.549

High

1153441

AT131
Endoplasmic reticulum transmembrane helix translocase

2

8

High-throughput

0.549

High

1153443

EI2BG
Translation initiation factor eIF2B subunit gamma

2

3

High-throughput

0.549

High

1153444

SAC1
Phosphatidylinositol-3-phosphatase SAC1

2

1

High-throughput

0.549

High

1153455

EI2BD
Translation initiation factor eIF2B subunit delta

2

6

High-throughput

0.549

High

1153416

O52N5
Olfactory receptor 52N5

1

2

High-throughput

0.536

High

1153427

CK5P3
CDK5 regulatory subunit-associated protein 3

1

4

High-throughput

0.536

High

1153453

S53A1
Solute carrier family 53 member 1

1

2

High-throughput

0.536

High

361696

F13A
Coagulation factor XIII A chain

1

3

High-throughput

0.514

High

1153399

LRRN1
Leucine-rich repeat neuronal protein 1

1

17

High-throughput

0.514

High

602217

TMM11
Transmembrane protein 11, mitochondrial

1

0

High-throughput

0.513

High

1153395

IPIL1
Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1

1

0

High-throughput

0.513

High

227090

SYNC
Asparagine--tRNA ligase, cytoplasmic

1

4

High-throughput

0.489

High

890834

TSC2
Tuberin

1

1

High-throughput

0.489

High

1085169

WASC5
WASH complex subunit 5

1

2

High-throughput

0.489

High

1153402

THADA
tRNA

1

3

High-throughput

0.489

High

1153424

SGSM3
Small G protein signaling modulator 3

1

6

High-throughput

0.489

High

1153445

TB22B
TBC1 domain family member 22B

1

6

High-throughput

0.489

High

1153446

INT7
Integrator complex subunit 7

1

1

High-throughput

0.489

High

1153456

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

1

High-throughput

0.489

High

1153463

YBOX2
Y-box-binding protein 2

1

1

High-throughput

0.489

High

1131466

MBTP1
Membrane-bound transcription factor site-1 protease

1

0

High-throughput

0.481

High

1153403

D19L3
Protein C-mannosyl-transferase DPY19L3

1

0

High-throughput

0.481

High

1153408

KLD8B
Kelch domain-containing protein 8B

1

0

High-throughput

0.481

High

1153417

DMXL2
DmX-like protein 2

1

0

High-throughput

0.481

High

440574

FYN
Tyrosine-protein kinase Fyn

1

16

Small-scale

0.479

High

1153388

2A5E
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform

1

4

High-throughput

0.445

High

1153410

EXOC8
Exocyst complex component 8

1

1

High-throughput

0.445

High

1153411

S39AB
Zinc transporter ZIP11

1

5

High-throughput

0.445

High

1153419

PBIP1
Pre-B-cell leukemia transcription factor-interacting protein 1

1

1

High-throughput

0.445

High

1153429

TS101
Tumor susceptibility gene 101 protein

1

1

High-throughput

0.445

High

1153437

TTYH1
Protein tweety homolog 1

1

1

High-throughput

0.445

High

1153440

GPAT1
Glycerol-3-phosphate acyltransferase 1, mitochondrial

1

1

High-throughput

0.445

High

1153452

ATX10
Ataxin-10

1

1

High-throughput

0.445

High

1153461

EXOC7
Exocyst complex component 7

1

2

High-throughput

0.445

High

1153438

GOLP3
Golgi phosphoprotein 3

1

0

High-throughput

0.426

High

1153457

VPS28
Vacuolar protein sorting-associated protein 28 homolog

1

0

High-throughput

0.426

High

1153464

TMM98
Transmembrane protein 98

1

0

High-throughput

0.426

High

2046

A0A0A6YYA0
Transmembrane emp24 domain-containing protein 7

1

4

High-throughput

0.407

High

137231

EXOC5
Exocyst complex component 5

1

2

High-throughput

0.407

High

214209

MCA3
Eukaryotic translation elongation factor 1 epsilon-1

1

1

High-throughput

0.407

High

231484

ORC4
Origin recognition complex subunit 4

1

5

High-throughput

0.407

High

828367

PEX19
Peroxisomal biogenesis factor 19

1

2

High-throughput

0.407

High

1085223

NU160
Nuclear pore complex protein Nup160

1

1

High-throughput

0.407

High

1153393

COQ5
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial

1

1

High-throughput

0.407

High

1153404

DYM
Dymeclin

1

2

High-throughput

0.407

High

1153405

HEAT3
HEAT repeat-containing protein 3

1

1

High-throughput

0.407

High

1153406

TMED4
Transmembrane emp24 domain-containing protein 4

1

3

High-throughput

0.407

High

1153412

VMA12
Vacuolar ATPase assembly protein VMA12

1

1

High-throughput

0.407

High

1153420

VP33A
Vacuolar protein sorting-associated protein 33A

1

5

High-throughput

0.407

High

1153421

KCD12
BTB/POZ domain-containing protein KCTD12

1

7

High-throughput

0.407

High

1153422

SAAL1
Protein SAAL1

1

5

High-throughput

0.407

High

1153425

INT4
Integrator complex subunit 4

1

1

High-throughput

0.407

High

1153426

DDRGK
DDRGK domain-containing protein 1

1

3

High-throughput

0.407

High

1153428

ELMO2
Engulfment and cell motility protein 2

1

1

High-throughput

0.407

High

1153430

CND3
Condensin complex subunit 3

1

1

High-throughput

0.407

High

1153432

INT2
Integrator complex subunit 2

1

2

High-throughput

0.407

High

1153433

LMA2L
VIP36-like protein

1

3

High-throughput

0.407

High

1153442

AT132
Polyamine-transporting ATPase 13A2

1

12

High-throughput

0.407

High

1153447

TM160
Transmembrane protein 160

1

4

High-throughput

0.407

High

1153450

VPS18
Vacuolar protein sorting-associated protein 18 homolog

1

1

High-throughput

0.407

High

1153460

SNX7
Sorting nexin-7

1

7

High-throughput

0.407

High

1153462

EXC6B
Exocyst complex component 6B

1

2

High-throughput

0.407

High

129119

MEN1
Menin

2

0

High-throughput

0.313

High

690705

AOFB
Amine oxidase [flavin-containing] B

2

0

High-throughput

0.313

High

1153409

TM192
Transmembrane protein 192

2

0

High-throughput

0.313

High

1153454

PCYOX
Prenylcysteine oxidase 1

2

0

High-throughput

0.313

High

317848

LTN1
E3 ubiquitin-protein ligase listerin

1

0

High-throughput

0.279

Low

1153392

TM128
Transmembrane protein 128

1

0

High-throughput

0.279

Low

1153396

CNDH2
Condensin-2 complex subunit H2

1

0

High-throughput

0.279

Low

1153423

BSCL2
Seipin

1

0

High-throughput

0.279

Low

62212

DEN11
DENN domain-containing protein 11

1

0

High-throughput

0.232

Low

351111

ECD
Protein ecdysoneless homolog

1

0

High-throughput

0.232

Low

1134912

CUL7
Cullin-7

1

0

High-throughput

0.232

Low

1153397

TX261
Protein TEX261

1

0

High-throughput

0.232

Low

1153398

LCLT1
Lysocardiolipin acyltransferase 1

1

0

High-throughput

0.232

Low

1153434

METL9
Protein-L-histidine N-pros-methyltransferase

1

0

High-throughput

0.232

Low

1153436

VPS16
Vacuolar protein sorting-associated protein 16 homolog

1

0

High-throughput

0.232

Low

1153449

COMD9
COMM domain-containing protein 9

1

0

High-throughput

0.232

Low

1153458

MA1B1
Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025