Protein: ACOT8
Acyl-coenzyme A thioesterase 8 (Acyl-CoA thioesterase 8) (EC 3.1.2.1) (EC 3.1.2.11) (EC 3.1.2.2) (EC 3.1.2.3) (EC 3.1.2.5) (Choloyl-coenzyme A thioesterase) (EC 3.1.2.27) (HIV-Nef-associated acyl-CoA thioesterase) (Peroxisomal acyl-CoA thioesterase 2) (PTE-2) (Peroxisomal acyl-coenzyme A thioester hydrolase 1) (PTE-1) (Peroxisomal long-chain acyl-CoA thioesterase 1) (Thioesterase II) (hACTE-III) (hACTEIII) (hTE)

Gene: ACOT8
Organism: Homo sapiens
Interactions: 63
UniProt ID: O14734

Gene Ontology (top 5):
GO:0003986 - acetyl-CoA hydrolase activity
GO:0004778 - succinyl-CoA hydrolase activity
GO:0005782 - peroxisomal matrix
GO:0005829 - cytosol
GO:0006636 - unsaturated fatty acid biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

162088

PML
Protein PML

4

1

High-throughput

0.691

High

162094

PEX5
Peroxisomal targeting signal 1 receptor

4

0

Small-scale

0.663

High

162097

REL
Proto-oncogene c-Rel

3

0

High-throughput

0.646

High

162087

PTN3
Tyrosine-protein phosphatase non-receptor type 3

2

0

High-throughput

0.585

High

162076

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

162082

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.518

High

162089

MK04
Mitogen-activated protein kinase 4

1

0

High-throughput

0.513

High

162108

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

162111

CDC26
Anaphase-promoting complex subunit CDC26

1

0

High-throughput

0.513

High

162129

FBX7
F-box only protein 7

1

0

High-throughput

0.480

High

162078

GCR
Glucocorticoid receptor

1

1

High-throughput

0.479

High

162124

PRD16
Histone-lysine N-methyltransferase PRDM16

1

0

High-throughput

0.460

High

122442

ADAS
Alkyldihydroxyacetonephosphate synthase, peroxisomal

1

0

High-throughput

0.458

High

156689

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.458

High

162077

CATA
Catalase

1

0

High-throughput

0.458

High

162079

ISG15
Ubiquitin-like protein ISG15

1

0

High-throughput

0.458

High

162081

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.458

High

162092

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

162095

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

162098

CUL3
Cullin-3

1

0

High-throughput

0.458

High

162099

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

162105

TBA1A
Tubulin alpha-1A chain

1

0

High-throughput

0.458

High

162110

MTMRE
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR14

1

0

High-throughput

0.458

High

162114

OTUL
Ubiquitin thioesterase otulin

1

0

Small-scale

0.458

High

162117

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

162125

NMRL1
NmrA-like family domain-containing protein 1

1

0

High-throughput

0.458

High

162127

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

162118

OSBL9
Oxysterol-binding protein-related protein 9

1

1

High-throughput

0.445

High

162120

OSB11
Oxysterol-binding protein-related protein 11

1

1

High-throughput

0.445

High

162072

BRD1
Bromodomain-containing protein 1

1

1

High-throughput

0.437

High

162084

TAF1
Transcription initiation factor TFIID subunit 1

1

3

High-throughput

0.437

High

162112

TP4A1
Protein tyrosine phosphatase type IVA 1

1

1

High-throughput

0.437

High

162119

RING2
E3 ubiquitin-protein ligase RING2

1

1

High-throughput

0.437

High

162122

BRD8
Bromodomain-containing protein 8

1

1

High-throughput

0.437

High

162123

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

162100

RHG29
Rho GTPase-activating protein 29

1

0

High-throughput

0.426

High

162101

A16L1
Autophagy-related protein 16-1

1

0

High-throughput

0.426

High

162116

GMPPA
Mannose-1-phosphate guanylyltransferase regulatory subunit alpha

1

0

High-throughput

0.426

High

162109

KLH23
Kelch-like protein 23

3

0

High-throughput

0.347

High

162106

P4HA3
Prolyl 4-hydroxylase subunit alpha-3

2

0

High-throughput

0.316

High

162115

COA7
Cytochrome c oxidase assembly factor 7

2

0

High-throughput

0.307

High

162073

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.279

Low

162080

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

High-throughput

0.279

Low

162102

VSTM1
V-set and transmembrane domain-containing protein 1

1

0

High-throughput

0.279

Low

162113

SNX21
Sorting nexin-21

1

0

High-throughput

0.279

Low

162128

MAST1
Microtubule-associated serine/threonine-protein kinase 1

1

0

High-throughput

0.279

Low

47928

RBM47
RNA-binding protein 47

1

0

High-throughput

0.249

Low

162070

TRI66
Tripartite motif-containing protein 66

1

0

High-throughput

0.249

Low

162071

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

162074

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.249

Low

162083

AMPN
Aminopeptidase N

1

0

High-throughput

0.249

Low

162086

SP100
Nuclear autoantigen Sp-100

1

0

High-throughput

0.249

Low

162090

PHB1
Prohibitin 1

1

0

High-throughput

0.249

Low

162091

BRCA1
Breast cancer type 1 susceptibility protein

1

0

High-throughput

0.249

Low

162096

VIGLN
Vigilin

1

0

High-throughput

0.249

Low

162104

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

162107

TM11B
Transmembrane protease serine 11B

1

0

High-throughput

0.249

Low

162075

IGHA1
Immunoglobulin heavy constant alpha 1

1

0

High-throughput

0.232

Low

162085

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.232

Low

162093

EAA2
Excitatory amino acid transporter 2

1

0

High-throughput

0.232

Low

162103

S39A5
Zinc transporter ZIP5

1

0

High-throughput

0.232

Low

162121

UNK
RING finger protein unkempt homolog

1

0

High-throughput

0.232

Low

162126

BCLF1
Bcl-2-associated transcription factor 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025